Day: September 18, 2020

Name is Tris[2-(dimethylamino)ethyl]amine, as a common heterocyclic compound, it belongs to chiral-nitrogen-ligands compound, and cas is 33527-91-2, its synthesis route is as follows.

To a solution of tris(2-dimethylaminoethyl)amine (0.403 g, 1.75 mmol) in acetonitrile (4 mL) was added 1-bromohexadecane (1.63 g, 5.35 mmol). The resulting mixture was heated at reflux with stirring for 18 hours, during which time awhite solid was observed. After cooling, and the addition of a cold hexanes/acetone mixture (15 mL, 1:1), to the reaction flask, the precipitate was filtered with a Buchner funnel, and rinsed with a cold hexanes/acetone mixture (2O mL, 1:1), resulting in T-16,16,16 (1.67 g, 84%) as a white powder; mp=229-258 C; ?H NMR (300 MI-Tz, CDC13) oe 4.11-4.02 (m, 6H), 3.64-3.55 (m, 6H), 3.45-3.37 (m, 6H), 3.35(s, 18H), 1.78-1.66 (m, 6H), 1.40-1.18 (m, 78H), 0.88-0.81 (m, 9H); high resolution mass spectrum (ESI) m/z 302.0073 ([Mj3 calculated for [C6oH,29N4j3: 302.0067). ?H spectmm of compound T-16,16,16 can be found in Figure 54.

33527-91-2, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,33527-91-2 ,Tris[2-(dimethylamino)ethyl]amine, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION; VILLANOVA UNIVERSITY; WUEST, William, M.; MINBIOLE, Kevin, P.C.; BARBAY, Deanna, L.; (227 pag.)WO2016/172436; (2016); A1;,
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

It is a common heterocyclic compound, the chiral-nitrogen-ligands compound, Tris[2-(dimethylamino)ethyl]amine, cas is 33527-91-2 its synthesis route is as follows.

General procedure: The copper complex Cu5-1 was dissolved in water, and an excessive amount of an aqueous solution of saturated sodium tetrafluoroborate (manufactured by Wako Pure Chemical Industries, Ltd.) was added while stirring. A precipitated solid was collected by filtering and a copper complex Cu5-72 was obtained.

33527-91-2, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,33527-91-2 ,Tris[2-(dimethylamino)ethyl]amine, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; FUJIFILM Corporation; Sasaki, Kouitsu; Kawashima, Takashi; Hitomi, Seiichi; Shiraishi, Yasuharu; US10215898; (2019); B2;,
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

As a common heterocyclic compound, it belongs to chiral-nitrogen-ligands compound, name is Tris[2-(dimethylamino)ethyl]amine, and cas is 33527-91-2, its synthesis route is as follows.

Embodiment 5Production of [Cu(Me6tren)]BPh4 0.20 g (0.87 mmol) Me6tren (1) was dissolved in approx. 2 ml acetone and a solution of 0.30 g (0.81 mmol) [Cu(CH3CN)4]PF6 (tetrakis(acetonitrile)copper(I)-hexafluorophosphate) in approx. 4 ml acetone was added slowly under constant stirring. A solution of 0.28 g (0.82 mmol) NaBPh4 (sodium tetraphenylborate) in approx. 2 mL acetone was added subsequently to the colorless, complex solution thus obtained, for the replacement of anions. For the preparation of the solid, the complex solution was added to 20 ml diethylether. The voluminous solid of [Cu(Me6tren)]BPh4 (10) obtained was dried in vacuum. 0.48 g (96.6%) of a colorless powder was obtained as the product.All work was carried out in an argon box. It is possible, however, to carry out all work with the Schlenk technique under argon or nitrogen as well.The complex [Cu(Me6tren)]BPh4 is shown in FIG. 1.The results of the crystal structure analysis of [Cu(Me6tren)]BPh4 are shown in FIG. 2.

33527-91-2, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,33527-91-2 ,Tris[2-(dimethylamino)ethyl]amine, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; Schindler, Siegfried; Wuertele, Christian; US2012/16127; (2012); A1;,
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

33527-91-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Tris[2-(dimethylamino)ethyl]amine, cas is 33527-91-2,the chiral-nitrogen-ligands compound, it is a common compound, a new synthetic route is introduced below.

General procedure: LiBEt3H (1 mL, 1.0 M in THF, 1 mmol) and Me6TREN (0.26 mL,1 mmol) were added to 5 mL of hexane, precipitating a white powder.THF was slowly added dropwise with stirring until a homogeneoussolution was obtained (approx. 3 mL) Cooling of the solutionat 30 C yielded X-ray quality colorless crystals

The chemical industry reduces the impact on the environment during synthesis,33527-91-2,Tris[2-(dimethylamino)ethyl]amine,I believe this compound will play a more active role in future production and life.

Reference£º
Article; Kennedy, Alan R.; McLellan, Ross; McNeil, Greg J.; Mulvey, Robert E.; Robertson, Stuart D.; Polyhedron; vol. 103; (2016); p. 94 – 99;,
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Name is N1,N2-Dimethylethane-1,2-diamine, as a common heterocyclic compound, it belongs to chiral-nitrogen-ligands compound, and cas is 110-70-3, its synthesis route is as follows.

HL1 was prepared by a modification of a method previouslyreported [23] and characterised by 1H NMR spectroscopy. Theligand was obtained as follows: to a solution of 2-hydroxybenzaldehyde(6.10 mL, 82.95 mmol) in absolute ethanol (250 mL),N,N’-dimethylethylenediamine (13.1 g, 100 mmol) and MgSO4were added. The suspension was stirred at room temperature for16 h and then filtered. The filtrate was concentrated under pressureto yield a yellow liquid, which was purified by distillation ina glass oven. Yield: 14.03 g (88%), b.p.: 145 C. 1H NMR (300 Hz,CDCl3) d: 11.52 (s, 1H, OH); 7.21 (td, J = 8.1 and 1.8 Hz, 1H, H6);6.97 (dd, J = 7.5 and 1.8 Hz, 1H, H4); 6.84 (dd, J = 8.4 and 1.2 Hz,1H, H7); 6.77 (td, J = 7.5 and 1.2 Hz, 1H, H5); 3.42 (s, 1H, H2);3.40 (m, 2H, 2H1); 2.59-2.53 (m, 2H, 2H1); 2.28 (s, 6H, 6H9) ppm.

110-70-3, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,110-70-3 ,N1,N2-Dimethylethane-1,2-diamine, other downstream synthetic routes, hurry up and to see

Reference£º
Article; Fondo, Matilde; Doejo, Jesus; Garcia-Deibe, Ana M.; Sanmartin, Jesus; Gonzalez-Bello, Concepcion; Vicente, Ramon; Polyhedron; vol. 100; (2015); p. 49 – 58;,
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

33527-91-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Tris[2-(dimethylamino)ethyl]amine, cas is 33527-91-2,the chiral-nitrogen-ligands compound, it is a common compound, a new synthetic route is introduced below.

LiBH4 (22 mg, 1 mmol) and Me6TREN (0.52 mL, 2 mmol) wereadded to 5 mL of THF. This was heated to reflux for 1 h at whichpoint the heat and stirrer were turned off. Slow cooling of the solutionyielded X-ray quality colorless crystals (40 mg, 16%).1H NMR (400.1 MHz, C6D6, 300 K): delta 2.11 (s, 18H, Me6TREN Me),1.94, 1.90 (overlapping br s, 12H, Me6TREN CH2), 0.59 ppm(quartet/septet, 4H, BH4, 1J10BH = 27.5 Hz, 1J11BH = 81.5 Hz).13C NMR (100.6 MHz, C6D6, 300 K): delta 57.0 (CH2), 51.2 (CH2),45.7 ppm (Me).7Li NMR (155.5 MHz, C6D6, 300 K): delta 0.29 ppm.11B NMR (128.3 MHz, C6D6, 300 K): delta 39.5 ppm (quin,1JBH = 81.2 Hz).Elemental analysis for C12H34N4LiB: Calc.: C, 57.15; H, 13.59; N,22.22. Found: C, 57.16; H, 13.48; N, 22.59%.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Tris[2-(dimethylamino)ethyl]amine, 33527-91-2

Reference£º
Article; Kennedy, Alan R.; McLellan, Ross; McNeil, Greg J.; Mulvey, Robert E.; Robertson, Stuart D.; Polyhedron; vol. 103; (2016); p. 94 – 99;,
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

As a common heterocyclic compound, it belongs to chiral-nitrogen-ligands compound, name is 3,4-Di(1H-indol-3-yl)-1H-pyrrole-2,5-dione, and cas is 119139-23-0, its synthesis route is as follows.

EXAMPLE 27 40 mg of a 60% suspension of sodium hydride in mineral oil was added to a solution of 327 mg of 3,4-bis-(3-indolyl)-1H-pyrrole-2,5-dione in 5 ml of DMF at 0 C. under nitrogen. After 0.5 hour the mixture was cooled to -20 C. and 108 mg of trimethylsilyl chloride were added. The mixture was allowed to warm to room temperature, then cooled to 0 C. and then a further 80 mg of sodium hydride were added thereto. After 0.5 hour at 0 C. 116 mg of propylene oxide were added and the mixture was stirred overnight. 5 ml of water were added and the mixture was extracted with dichloromethane. The organic phase was dried and evaporated. The residue was purified on silica gel with ethyl acetate/petroleum ether. Recrystallization from diethyl ether/petroleum ether gave 30 mg of 3,4-bis[1-(2-hydroxypropyl)-3-indolyl]-1H-pyrrole-2,5-dione, m.p. 133-135 C.

119139-23-0, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,119139-23-0 ,3,4-Di(1H-indol-3-yl)-1H-pyrrole-2,5-dione, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; Hoffmann-La Roche Inc.; US5057614; (1991); A;,
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

110-70-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. N1,N2-Dimethylethane-1,2-diamine, cas is 110-70-3,the chiral-nitrogen-ligands compound, it is a common compound, a new synthetic route is introduced below.

To a stirred solution of Lambda/,Lambda/’-dimethylethylene diamine (3.66 mL, 34 mmol) in dichloromethane (40 mL) at 0C was added dropwise a solution of di-tert-butyl dicarbonate (2.4 g, 11 mmol) in dichloromethane (20 mL) and allowed to warm to room temperature overnight, concentrated under reduced pressure, diluted with EtOAc (100 mL), washed with water (2 * 100 mL), brine (100 mL), dried and concentrated under reduced pressure to give the title product 91 as a colourless oil (1.54 g, 74% yield). 1H NMR (400 MHz, CDCI3) delta 3.26 (t, J = 6.15 Hz, 2H), 2.81 (s, 3H), 2.66 (t, J = 6.57 Hz, 2H), 2.38 (s, 3H), 9.28 (s, 9H) ppm.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of N1,N2-Dimethylethane-1,2-diamine, 110-70-3

Reference£º
Patent; ANTIKOR BIOPHARMA LIMITED; DEONARAIN, Mahendra Persaud; YAHIOGLU, Gokhan; STAMATI, Ioanna; SAOUROS, Savvas; KAPADNIS, Prashant Bhimrao; (423 pag.)WO2016/46574; (2016); A1;,
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

It is a common heterocyclic compound, the chiral-nitrogen-ligands compound, N1,N2-Dimethylethane-1,2-diamine, cas is 110-70-3 its synthesis route is as follows.

General procedure: To a cooled to 0 C suspension consisting of N,N’-dimethyl-1,2-ethylenediamine (4.4 g, 0.05 mol), sodium bicarbonate (33.6 g, 0.40 mol), and CH2Cl2 (50 mL), a solution of 2-bromopropionyl chloride (1a) (25.7 g, 0.15 mol) in CH2Cl2 (40 mL) was added. The reaction temperature was maintained within 0-5 C and the addition time was 40 min. The mixture was stirred for 4 h at the same temperature. Water (130 mL) and CH2Cl2 (60 mL) were added and the organic layer was separated. The combined organic fractions were dried over sodium sulfate. The solvent was removed under reduced pressure. The residue was treated with hexane (30 mL) and a solid product was filtered off and recrystallized from diethyl ether to give pure compound 2a (13.25 g, 74%), m.p. 77.0-77.4 C (from diethyl ether).

110-70-3, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,110-70-3 ,N1,N2-Dimethylethane-1,2-diamine, other downstream synthetic routes, hurry up and to see

Reference£º
Article; Goncharova; Yakushchenko; Raevskaya; Yakushchenko; Konovalova; Russian Chemical Bulletin; vol. 68; 1; (2019); p. 181 – 185; Izv. Akad. Nauk, Ser. Khim.; 1; (2019); p. 181 – 185,5;,
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Name is 3,4-Di(1H-indol-3-yl)-1H-pyrrole-2,5-dione, as a common heterocyclic compound, it belongs to chiral-nitrogen-ligands compound, and cas is 119139-23-0, its synthesis route is as follows.

EXAMPLE 10 1.4 ml of acetaldehyde dimethyl acetal and 10 mg of p-toluenesulphonic acid were added to a solution of 250 mg of 3,4-bis(3-indolyl)-1H-pyrrole-2,5-dione in 40 ml of chloroform. The resulting mixture was heated to reflux for 18 hours under nitrogen. The obtained solution was evaporated and the residue was purified on silica gel with ethyl acetate/petroleum ether (1:2). Recrystallization from chloroform/hexane gave 165 mg of 3,4-bis[1-(1-methoxyethyl)-3-indolyl]-1H-pyrrole-2,5-dione, m.p. 222-224 C.

119139-23-0, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,119139-23-0 ,3,4-Di(1H-indol-3-yl)-1H-pyrrole-2,5-dione, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; Hoffmann-La Roche Inc.; US5057614; (1991); A;,
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis