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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

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Compounds represented by formula (1) have strong inhibitory activity that is selective towards HDAC1 and HDAC4. Therefore, the compounds of the present invention are useful as pharmaceutical agents for treating or preventing diseases caused by HDAC1 and HDAC4.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

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Adsorption of 16 organic compounds from the gas phase by 4-{4-[4(S)-2-methyl-1-butoxybenzoyloxy]phenyldiazenyl}benzaldehyde was studied by gas chromatography. It was shown by means of differential scanning calorimetry that 4-{4-[4(S)-2-methyl-1-butoxybenzoyloxy]phenyldiazenyl]benzaldehyde is an enantiotropic polymorphic mesogen and forms smectic and nematic liquid crystal phases. Electron-donor isomers of methylpyridine and dimethylpyridine, isomers of weakly polar xylenes and cresols, and enantiomers of 2,3-butanediol and terpene hydrocarbons, capable of various types of intermolecular interactions with mesogenic aldehyde, were selected as adsorbates. Specific retention volumes of adsorbates and criteria for their separation were calculated. The effect of temperature and chemical nature of the adsorbates on their adsorption redistribution in the gas?liquid crystal system is discussed. It was found experimentally that the adsorbent based on 4-{4-[4(S)-2-methyl-1-butoxybenzoyloxy]phenyldiazeny}lbenzaldehyde exhibits high selectivity for close-boiling organic compounds of various nature and good efficiency and productivity in their separation.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

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Coordination of a chiral substrate to (meso-salen)cobalt(II) nitrate and subsequent oxidation generates a Co(III) complex exhibiting a strong chiroptical readout that is attributed to spontaneous substrate-to-ligand chirality imprinting. The characteristic circular dichroism (CD) response of the (salen)cobalt complex can be used for enantiomeric analysis of a variety of chiral substrates based on a simple CD measurement at low concentration and without additional purification steps. This chirality sensing approach has potential for high-throughput enantiomeric excess (ee) screening applications and minimizes solvent waste production. Copyright

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

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In continuation of our work on excess thermodynamic properties of non-electrolyte solutions containing pyridine bases with n-alkanes, we have determined excess molar volumes VE for 2,4-ditnethylpyridine + C6 to C10 n-alkanes at 25C. For the investigated systems no VE values were available in the literature for compari1 son with our data. The experimental VE was used to test the Prigogine-Flory-Patterson theory (PFP), Extended Real Associated Solutions model (ERAS) and the Treszczanowicz-Benson method (TB).

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

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The regioselective silylation of C(sp3)-H bonds at the benzylic position in 4-alkylpyridines with hydrosilanes is described. The reaction proceeds in the presence of a catalytic amount of Ir4(CO)12 or Ir(acac)(CO)2, which possess CO as a ligand, or [Ir(OMe)(cod)]2 under 1 atm of CO. After optimizing the reaction conditions, by using other pyridine derivatives, such as 3,5-dimethylpyridine, as additives, the low product yields of 2-substituted 4-methylpyridines were improved markedly.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

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Continued exploration of the SAR around the lead imidazopyridine histamine H3 antagonist 1 has led to the discovery of several related series of heterocyclic histamine H3 antagonists. The synthesis and SAR of indolizine, indole and pyrazolopyridine based compounds are now described.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

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The aim of this study was to evaluate the physicochemical and textural characteristics and volatile compounds of Kazakh dry-cured beef made in China. Two types of Kazakh dry-cured beef were investigated: Kazakh drycured beef made with smoking and spices (T1) and without smoking and spices (T2). There were significant (P < 0.05) differences in values of aw, moisture, L?, cohesiveness and chewiness between the two types. A total of 86 volatile compounds were isolated by solid phase microextraction-gas chromatography/mass spectrometry (SPME-GC/MS). Hydrocarbons were the most abundant in T1 products and aldehydes in T2 products. Principal component analysis showed that the first principal component (PC1) was highly related to smoke derivatives- naphthalene, 2-cyclopenten-1-one derivatives, 4-methyl-4-hepten-3-one, acetophenone, 2,3-dihydro-1H-Inden-1-one, 2-furanmethanol, methoxy-phenyl-oxime, furfural, 1-(2-furanyl)-ethanone and phenols-and the second principal component (PC2) to lipid derivatives-straight-chain aliphatic aldehydes, methyl ketone, straight-chain alcohols and 2-pentyl-furan. The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction. the role of 108-47-4, and how the biochemistry of the body works.Synthetic Route of 108-47-4

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

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The products of the condensation reactions of twenty-six different 1,2-amino alcohols with excess aqueous formaldehyde were identified, with the help of a simple and effective analytical technique based on mass spectroscopy. With a few exceptions, which arise from steric or solubility effects, most amino alcohols form bis(oxazolidine)methane adducts preferentially.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

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The iridium-catalysed C-H borylation is a valuable and attractive method for the preparation of aryl and heteroaryl boronates. However, application of this methodology for the preparation of pyridyl and related azinyl boronates can be challenged by low reactivity and propensity for rapid protodeborylation, particularly for a boronate ester ortho to the azinyl nitrogen. Competition experiments have revealed that the low reactivity is due to inhibition of the active catalyst through coordination of the azinyl nitrogen lone pair at the vacant site on the iridium. This effect can be overcome through the incorporation of a substituent at C-2. Moreover, when this is sufficiently electron-withdrawing protodeborylation is sufficiently slowed to permit isolation and purification of the C-6 boronate ester. Following functionalization, reduction of the directing C-2 substituent provides the product arising from formal ortho borylation of an unhindered pyridine ring. This journal is the Partner Organisations 2014.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis