Day: March 30, 2022

COA of Formula: C26H24P2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1,2-Bis(diphenylphosphino)ethane, is researched, Molecular C26H24P2, CAS is 1663-45-2, about The palladacycle, BTC2, exhibits anti-breast cancer and breast cancer stem cell activity. Author is Kimani, Serah; Chakraborty, Suparna; Irene, Ikponmwosa; de la Mare, Jo; Edkins, Adrienne; du Toit, Andre; Loos, Ben; Blanckenberg, Angelique; Van Niekerk, Annick; Costa-Lotufo, Leticia V.; ArulJothi, KN.; Mapolie, Selwyn; Prince, Sharon.

In women globally, breast cancer is responsible for most cancer-related deaths and thus, new effective therapeutic strategies are required to treat this malignancy. Platinum-based compounds like cisplatin are widely used to treat breast cancer, however, they come with limitations such as poor solubility, adverse effects, and drug resistance. To overcome these limitations, complexes containing other platinum group metals such as palladium have been studied and some have already entered clin. trials. Here we investigated the anti-cancer activity of a palladium complex, BTC2, in MCF-7 estrogen receptor pos. (ER+) and MDA-MB-231 triple neg. (TN) human breast cancer cells as well as in a human breast cancer xenograft chick embryo model. BTC2 exhibited an average IC50 value of 0.54μM, a desirable selectivity index of >2, inhibited the migration of ER+ and TN breast cancer cells, and displayed anti-cancer stem cell activity. We demonstrate that BTC2 induced DNA double strand breaks (increased levels of γ-H2AX) and activated the p-ATM/p-CHK2 and p-p38/MAPK pathways resulting in S- and G2/M-phase cell cycle arrests. Importantly, BTC2 sensitized breast cancer cells by triggering the intrinsic (cleaved caspase 9) and extrinsic (cleaved caspase 8) apoptotic as well as necroptotic (p-RIP3 and p-MLKL) cell death pathways and inhibiting autophagy and its pro-survival role. Furthermore, in the xenograft in vivo model, BTC2 displayed limited toxicity and arrested the tumor growth of breast cancer cells over a 9-day period in a manner comparable to that of the pos. control drug, paclitaxel. BTC2 thus displayed promising anti-breast cancer activity.

If you want to learn more about this compound(1,2-Bis(diphenylphosphino)ethane)COA of Formula: C26H24P2, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(1663-45-2).

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Tri(naphthalen-1-yl)phosphine, is researched, Molecular C30H21P, CAS is 3411-48-1, about Reaction of 1-bromonaphthalene with PH3 in the t-BuOK/DMSO system: PCl3-free synthesis of di(1-naphthyl)phosphine and its oxide.Formula: C30H21P.

The phosphine, generated together with hydrogen from red phosphorus and aqueous KOH, reacts with 1-bromonaphthalene in the t-BuOK/DMSO system under mild conditions (70 °C, atm. pressure) to give di(1-naphthyl)phosphine, which is easily oxidized in the presence of air to afford di(1-naphthyl)phosphine oxide in 45% preparative yield. Tri(1-naphthyl)phosphine and naphthalene are also formed in the reaction in 23 and 27% yield, resp. According to ESR and UV data, the studied phosphination of 1-bromonaphthalene involves a single electron transfer process.

If you want to learn more about this compound(Tri(naphthalen-1-yl)phosphine)Formula: C30H21P, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(3411-48-1).

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

HPLC of Formula: 111-24-0. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1,5-Dibromopentane, is researched, Molecular C5H10Br2, CAS is 111-24-0, about Approaches to the synthesis of dicarboxylic derivatives of bis(pyrazol-1-yl)alkanes. Author is Burlutskiy, Nikita P.; Potapov, Andrei S..

Carboxylation of bis(pyrazol-1-yl)alkanes by oxalyl chloride was studied. It was found that 4,4′-dicarboxylic derivatives of substrates with electron-donating Me groups and short linkers (from one to three methylene groups) can be prepared using this method. Longer linkers lead to significantly lower product yields, which was probably due to instability of the intermediate acid chlorides that are initially formed in the reaction with oxalyl chloride. Thus, bis(pyrazol-1-yl)methane gave only monocarboxylic derivative even with a large excess of oxalyl chloride and prolonged reaction duration. An alternative approach involves the reaction of Et 4-pyrazolecarboxylates with dibromoalkanes in a superbasic medium (potassium hydroxide-dimethyl sulfoxide) and was suitable for the preparation of bis(4-carboxypyrazol-1-yl)alkanes with both short and long linkers independent of substitution in positions 3 and 5 of pyrazole rings. The obtained dicarboxylic acids are interesting as potential building blocks for metal-organic frameworks.

If you want to learn more about this compound(1,5-Dibromopentane)HPLC of Formula: 111-24-0, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(111-24-0).

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Han, Peilin; Han, Huijuan; Zhang, Xiaowei; Hou, Xiaoxiao; Wang, Hui; Liu, Chunhui published an article about the compound: 1,2-Bis(diphenylphosphino)ethane( cas:1663-45-2,SMILESS:P(CCP(C1=CC=CC=C1)C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4 ).Application of 1663-45-2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1663-45-2) through the article.

The competing mechanisms of silver-/aminolithium-catalyzed hydrofunctionalization of α,β-unsaturated ester with an amino alc. have been systematically studied with the DFT methods. Here, the acidity of a weaker nucleophile OH group of an amino alc. is significantly higher than that of NH2 group, so it is easy to deprotonate by Ag(HMDS)/dppe. However, the generated Ag-O bond is more stable than the corresponding Ag-N bond. Therefore, the OH group shows higher reactivity than the NH2 group in the presence of a Lewis acid/Bronsted base pair catalyst. Then, α,β-unsaturated esters can be inserted into corresponding Ag-O bonds to obtain alkyl silver species. Alkyl silver can be protonated by bis(trimethylsilyl)amines to obtain hydrogen functionalized products and regenerate silver amino active compounds Ag(HMDS)/dppe.

If you want to learn more about this compound(1,2-Bis(diphenylphosphino)ethane)Application of 1663-45-2, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(1663-45-2).

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Related Products of 1663-45-2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1,2-Bis(diphenylphosphino)ethane, is researched, Molecular C26H24P2, CAS is 1663-45-2, about Synthesis, crystallographic studies, antibacterial and antifungal activities of mononuclear mercury(II) complexes derived from [PPh2(CH2)nPPh2CH2C(O)C6H4Cl]Br ligands.

This account describes authors recent studies on zwitterionic mercury(II) complexes with two diphosphonium salts, [PPh2(CH2)nPPh2CH2C(O)C6H4Cl]Br (n = 1 (S1) and 2 (S2)), derived from 1,2-bis(diphenyl-phosphino)methane (dppm) and 1,2-bis(diphenyl-phosphino)ethane (dppe). These complexes were synthesized through reactions between diphosphonium salts and HgX2 in equimolar ratio and characterized by elemental anal., IR, 1H, 13C and 31P NMR spectroscopic methods. The structure of complex [HgI2Br(PPh2(CH2)2PPh2CH2C(O)C6H4Cl)] (6) was determined by a single crystal x-ray structural anal. The results indicated that the mercury center in this complex is four-coordinated in a distorted tetrahedral configuration. The results confirmed that the coordination of ligand to metal occurred through the phosphine group (P-coordination mode). Furthermore, antibacterial/antifungal activities of the diphosphonium ligands and their complexes were tested against two Gram-neg. bacteria Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 9027) and two Gram-pos. bacteria Staphylococcus aureus (ATCC 6538) and Bacillus subtilis (ATCC 6633) as well as two fungi (Geotrichum sp. and Candida albicans). It seems that the chem. compounds reported herein may be used for control of pathogenic bacteria/fungi.

If you want to learn more about this compound(1,2-Bis(diphenylphosphino)ethane)Related Products of 1663-45-2, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(1663-45-2).

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1,2-Bis(diphenylphosphino)ethane, is researched, Molecular C26H24P2, CAS is 1663-45-2, about Revising the chemistry of κ2-dppe-closo-RuC2B9H11 fragment: Synthesis of novel diamagnetic complexes and its transformations, the main research direction is ruthenium carborane phosphine complex preparation haptotropic rearrangement; redox reaction potential ruthenium carborane phosphine complex; atom transfer radical polymerization catalyst ruthenium carborane phosphine complex; methyl methacrylate polymerization atom transfer radical catalyst ruthenium carborane.Recommanded Product: 1663-45-2.

A novel facile way of synthesis of closo-ruthenacarboranes with chelate 1,2-bis(diphenylphosphino)ethane (dppe) with high yields was proposed. It was found that the interaction of the three-bridged 5,6,10-{Cl(Ph3P)2Ru}-[5,6,10-(μ-H)3-10-H-exo-nido-7,8-C2B9H10] (1) with dppe in acetonitrile or CH2Cl2/acetonitrile mixture leads to the formation of novel diamagnetic ruthenacarborane cluster 3-CNMe-3,3-[κ2-dppe]-closo-3,1,2-RuC2B9H11 (2) along with some amount of ionic compound [trans-(CH3CN)RuCl(dppe)2]+[C2B9H12]- (3) which may be also converted to 2 increasing its total yield. The reaction of 2 bearing divalent ruthenium with carbon tetrachloride or HCl gives the known 17-electron paramagnetic complex 3-Cl-3,3-[κ2-dppe]-closo-3,1,2-RuC2B9H11 (4). The detailed investigation of the previously described method of synthesis of 4 from 3-H-3-Cl-3,3-(PPh3)2-closo-3,1,2-RuC2B9H11 (5) allowed us to characterize the forming byproducts as 3-PPh3-3,3,8-[Ph2P(CH2)2PPh-μ-(C6H4-o)-closo-3,1,2-RuC2B9]H10 (6) and 3-[κ1-dppe]-3,3-[κ2-dppe]-closo-3,1,2-RuC2B9H11 (7). The obtained ruthenacarborane clusters undergo reversible Ru(II)/Ru(III) transition. It was shown that the complexes 2, 4 and 6 show good activity as catalysts for Atom Transfer Radical Polymerization of Me methacrylate.

If you want to learn more about this compound(1,2-Bis(diphenylphosphino)ethane)Recommanded Product: 1663-45-2, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(1663-45-2).

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Solid-State Coordination Chemistry of Copper(II) Tetrazolates: Anion Control of Frameworks Constructed from Trinuclear Copper(II) Building Blocks, published in 2009-06-01, which mentions a compound: 14389-12-9, Name is 5-(4-Pyridyl)-1H-tetrazole, Molecular C6H5N5, Electric Literature of C6H5N5.

The products of the reactions of Cu(II) starting materials with 4-pyridyltetrazole (4-Hpt) in DMF/MeOH solutions are determined by the anion identity and concentration In the absence of chloride, the 3-dimensional open-framework material [Cu3(OH)3(4-pt)3(DMF)4]·5DMF·3MeOH (1·5DMF·3MeOH) is isolated, while variations in the chloride concentration yield the 2-dimensional and 3-dimensional materials, [Cu3Cl4(4-pt)2(4Hpt)2]·4DMF·2MeOH (2) and [Cu3Cl2(4-pt)4]·4DMF·4MeOH (3), resp. All three structures exhibit trinuclear Cu(II) building blocks: the triangular {Cu3(μ3-OH)}5+ core in 1 and {Cu3Cl4(4-pt)4(4-Hpt)2}2- and {Cu3Cl2(4-pt)8}4- chains in 2 and 3, resp. All three materials display microporosity, which is highly dependent on the method of sample preparation

If you want to learn more about this compound(5-(4-Pyridyl)-1H-tetrazole)Electric Literature of C6H5N5, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(14389-12-9).

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Application In Synthesis of 5-(4-Pyridyl)-1H-tetrazole. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 5-(4-Pyridyl)-1H-tetrazole, is researched, Molecular C6H5N5, CAS is 14389-12-9, about Simple and efficient synthesis of 5-substituted 1-H-tetrazoles using metal-modified clay catalysts. Author is Chermahini, Alireza Najafi; Teimouri, Abbas; Moaddeli, Ali.

The synthesis of 5-substituted 1-H-tetrazoles based on reaction of a series of aromatic nitriles with sodium azide was investigated. The reaction was catalyzed by modified montmorillonite K-10 including Cu2+, Fe3+, Ni2+, and Zn2+ metal ions. The best results obtained by Mont-K10-Cu catalyst. The catalysts were reused several times without loss of their activity. The present procedure offers advantages such as a shorter reaction time, simple workup, recovery, and reusability of the catalyst.

If you want to learn more about this compound(5-(4-Pyridyl)-1H-tetrazole)Application In Synthesis of 5-(4-Pyridyl)-1H-tetrazole, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(14389-12-9).

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Category: chiral-nitrogen-ligands. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1,5-Dibromopentane, is researched, Molecular C5H10Br2, CAS is 111-24-0, about Synthesis and Antileishmanial Evaluation of Arylimidamide-Azole Hybrids Containing a Phenoxyalkyl Linker.

A mol. hybridization approach was employed where arylimidamide and azole groups were separated by phenoxyalkyl linkers in an attempt to capitalize on the favorable antileishmanial properties of both series I [X = Y = Z = CH, N; n = 2, 3, 4, 5, 6, 8, 10; R1 = R2 = H, OMe, Cl, OEt, Oi-Pr] and II. Among the target compounds synthesized I, a greater antileishmanial potency against intracellular Leishmania donovani were observed as the linker length increased from two to eight carbons and when an imidazole ring was employed as the terminal group compared to a 1,2,4-triazole group. Compound I [X = CH, Y = Z = N, R1 = H, R2 = Oi-Pr] displayed activity against L. donovani intracellular amastigotes with an IC50 value of 0.53μM. When tested in a murine visceral leishmaniasis model, compound I [X = Y = Z = CH, N; n = 2, 3, 4, 5, 6, 8, 10; R1 = R2 = H, OMe, Cl, OEt, Oi-Pr] at a dose of 75 mg/kg/day p.o. for five consecutive days resulted in a modest 33% decrease in liver parasitemia compared to the control group, which indicated that further optimization of these mols. were needed. While potent hybrid compounds bearing an imidazole terminal group were also strong inhibitors of recombinant CYP51 from L. donovani, as assessed by a fluorescence-based assay, addnl. targets were likely to play an important role in the antileishmanial action of these compounds

If you want to learn more about this compound(1,5-Dibromopentane)Category: chiral-nitrogen-ligands, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(111-24-0).

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Tri(naphthalen-1-yl)phosphine, is researched, Molecular C30H21P, CAS is 3411-48-1, about Highly active, stable, catalysts for the Heck reaction; further suggestions on the mechanism.Category: chiral-nitrogen-ligands.

Tri(1-naphthyl)phosphine gives palladacycles which are very active catalysts for Heck reactions; mechanisms based on a PdII-PdIV cycle are proposed and a new, very efficient method of separating the product from the catalyst has been devised, which involves treatment with cyanide ion.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis