Day: April 12, 2022

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Aminoquinazolin-4(3H)-one( cas:20198-19-0 ) is researched.Application of 20198-19-0.Masharipov, S. M.; Nazhimov, K. O.; Kasymova, S. S.; Askarov, M. A. published the article 《New acrylic monomers》 about this compound( cas:20198-19-0 ) in Doklady Akademii Nauk UzSSR. Keywords: crotonylquinazolinone preparation polymerization vinyl chloride; quinazolinone crotonyl preparation polymerization; vinyl chloride crotonylquinazolinone copolymer; thermal stability chloroethene crotonylquinazolinone copolymer. Let’s learn more about this compound (cas:20198-19-0).

2-(Crotonoylamino)quinazolin-4-one (I) and 2-(crotonoylamino)-3-methylquinazolin-4-one (II) monomers were prepared by reaction of 2-aminoquinazolin-4-one and 2-amino-3-methylquinazolin-4-one with crotonoyl chloride. During polymerization of the monomers with vinyl chloride (III), the polymerization rate decreased with increasing content of I or II at concentrations ≤5%. The incorporation of I or II in III polymers led to improved oxidative thermal stability, with maximum stability observed at 0.5-0.6% I or II.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Application In Synthesis of 1,2-Bis(diphenylphosphino)ethane. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1,2-Bis(diphenylphosphino)ethane, is researched, Molecular C26H24P2, CAS is 1663-45-2, about Photophysical Properties of Cyclometalated Platinum(II) Diphosphine Compounds in the Solid State and in PMMA Films. Author is Coffey, Belle; Clough, Lily; Bartkus, Daphne D.; McClellan, Ian C.; Greenberg, Matthew W.; LaFratta, Christopher N.; Tanski, Joseph M.; Anderson, Craig M..

Platinum(II) compounds were synthesized with both chelate cyclometalated ligands and chelate diphosphine ligands. The cyclometalated ligands include phenylpyridine and a benzothiophene-containing ligand. The three new benzothiophene compounds were characterized by NMR (NMR) spectroscopy, high-resolution mass spectrometry (HR-MS), and photophys. measurements. In the case of one compound, L1-DPPM, the structure was determined by single crystal X-ray diffraction. The structural coherence of the noncrystalline emissive solid state was measured by X-ray total scattering real space pair distribution function anal. Quantum yield values of all of the platinum compounds measured in the solid state and in PMMA films were much greater than in solution

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Quality Control of 2-Aminoquinazolin-4(3H)-one. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about New methods for the synthesis of 1,2,3,5-tetrahydroimidazo[2,1-b]-quinazoline-2,5-diones. Author is Vlasenko, A. F.; Mazur, I. A.; Kochergin, P. M..

2-Chloro-4-quinazolone reacted with BrCH2CO2Me and then RNH2 (R = H, CH2CH2OH, Bu, Ph, p-MeC6H4, p-ClC6H4) to give the title compounds I (R1 = H). These compounds and I (R = p-ClC6H4, R1 = Et) were also prepared from the corresponding 2-amino-4-quinazolones and BrCHR1CO2H or their esters.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Three AgI, CuI and CdII coordination polymers based on the new asymmetrical ligand 2-{4-[(1H-imidazol-1-yl)methyl]phenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazole: syntheses, characterization and emission properties, published in 2019-12-01, which mentions a compound: 14389-12-9, Name is 5-(4-Pyridyl)-1H-tetrazole, Molecular C6H5N5, Application of 14389-12-9.

The new asym. organic ligand 2-{4-[(1H-imidazol-1-yl)methyl]phenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazole (L, C17H13N5O), containing pyridine and imidazole terminal groups, as well as potential oxdiazole coordination sites, was designed and synthesized. The coordination chem. of L with soft AgI, CuI and CdII metal ions was investigated and three new coordination polymers (CPs), namely, catena-poly[[silver(I)-μ-2-{4-[(1H-imidazol-1-yl)methyl]phenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazole] hexafluoridophosphate], {[Ag(L)]PF6}n, catena-poly[[copper(I)-di-μ-iodido-copper(I)-bis(μ-2-{4-[(1H-imidazol-1-yl)methyl]phenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazole)] 1,4-dioxane monosolvate], {[Cu2I2(L)2]·C4H8O2}n, and catena-poly[[[dinitratocopper(II)]-bis(μ-2-{4-[(1H-imidazol-1-yl)methyl]phenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazole)]-methanol-water (1/1/0.65)], {[Cd(L)2(NO3)2]·2CH4O·0.65H2O}n, were obtained. The exptl. results show that ligand L coordinates easily with linear AgI, tetrahedral CuI and octahedral CdII metal atoms to form one-dimensional polymeric structures. The intermediate oxadiazole ring does not participate in the coordination interactions with the metal ions. In all three CPs, weak π-π interactions between the nearly coplanar pyridine, oxadiazole and benzene rings play an important role in the packing of the polymeric chains.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Abdpour, Shahin; Jalili-Baleh, Leili; Nadri, Hamid; Forootanfar, Hamid; Bukhari, Syed Nasir Abbas; Ramazani, Ali; Ebrahimi, Seyed Esmaeil Sadat; Foroumadi, Alireza; Khoobi, Mehdi researched the compound: 1,5-Dibromopentane( cas:111-24-0 ).Related Products of 111-24-0.They published the article 《Chromone derivatives bearing pyridinium moiety as multi-target-directed ligands against Alzheimer’s disease》 about this compound( cas:111-24-0 ) in Bioorganic Chemistry. Keywords: pyridiniumyl alkoxy phenyl chromenone preparation cytotoxicity ADMET docking neuroprotective; chromenone pyridiniumyl alkoxy preparation human AChE BuChE inhibition antitumor; Alzheimer’s disease; Anti-amyloid aggregation; Cholinesterase inhibitors; Chromone; Neuroprotective activity; Pyridinium salts. We’ll tell you more about this compound (cas:111-24-0).

A new serise of 7-hydroxy-chromone derivatives bearing pyridine moiety I [R = H, Ph, 4-ClC6H4, etc.; R1 = H, Et; n= 3, 4, 5] were synthesized and evaluated as multifunctional agents against Alzheimer’s disease (AD). Most of the compounds I were good AChE inhibitors (IC50 = 9.8-0.71μM) and showed remarkable BuChE inhibition activity (IC50 = 1.9-0.006μM) compared with donepezil as the standard drug (IC50 = 0.023 and 3.4μM). Compounds I [R = 4-ClC6H4, R1 = H, n = 4] and I [R = 4-MeOC6H4, R1 = Et, n = 3] showed the best inhibitory activity toward AChE (IC50 = 0.71μM) and BuChE (IC50 = 0.006μM), resp. The ligand-protein docking simulations and kinetic studies revealed that compound I [R = 4-ClC6H4, R1 = H, n = 4] and I [R = 4-MeOC6H4, R1 = Et, n = 3] could bind effectively to the peripheral anionic binding site (PAS) of the AChE and BuChE through mixed-type inhibition. In addition, the most potent compounds I [R = 4-ClC6H4, 4-MeC6H4, R1 = H, Et, n = 4, 3] showed acceptable neuroprotective activity on H2O2- and Aβ-induced .neurotoxicity in PC12 cells, more than standard drugs. The compounds I could block effectively self- and AChE-induced Aβ aggregation. All the results suggest that compounds I [R = 4-ClC6H4, 4-MeC6H4, R1 = H, Et, n = 4, 3] could be considered as promising multi-target-directed ligands against AD.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Product Details of 14389-12-9. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 5-(4-Pyridyl)-1H-tetrazole, is researched, Molecular C6H5N5, CAS is 14389-12-9, about Click chemistry for the synthesis of 5-substituted 1H-tetrazoles from boron-azides and nitriles. Author is Yao, Yue-Wei; Zhou, Yi; Lin, Bao-Ping; Yao, Cheng.

A novel and metal free catalysis of synthesizing 5-substituted 1H-tetrazoles through 1,3-dipolar cycloaddition of boron-azides and nitriles is reported with broad substrate scope and excellent yields.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

HPLC of Formula: 1663-45-2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1,2-Bis(diphenylphosphino)ethane, is researched, Molecular C26H24P2, CAS is 1663-45-2, about Inclusion of bidentate phosphine molecules in the supercage of FAU zeolite. Author is Okumura, Kazu; Morita, Sachiko; Ohtsuki, Akimichi; Takaba, Hiromitsu.

Bidentate phosphines (Ph2P(CH2)nPPh2) with different alkyl chain lengths (n = 1-10) were included in the supercage (SC) of FAU-zeolite. Thermal treatment of the mixture of a bidentate phosphines and FAU-zeolite at 443 K resulted in the inclusion of the former into the SC, with ≤ 0.75 mols. per SC. The included mols. were strongly bound by FAU-zeolite, with desorption observed at higher temperatures compared to those of unloaded ones. The sp. surface area of the FAU-zeolite decreased linearly with an increase in the number of phosphines included. This tendency was more emphasized in phosphines with n = 6-10 compared with those with n = 1-5. A characteristic shift in the C-C stretching band of the benzene ring was observed in the Fourier-transform IR spectroscopy (FT-IR) spectrum, due to the strong interaction between bidentate phosphines and FAU-zeolite; the extent was more when using *BEA-loaded ones. Formation of the inclusion compounds between bidentate phosphines and FAU zeolites was observed with the mol. dynamics (MD) calculations The bidentate phosphines included in the SC of the FAU-zeolite were reacted with PdCl2 to form Pd complexes. The detailed anal. of the Pd complexes with Pd K-edge EXAFS revealed a characteristic decrease in the Pd-Cl bond distance with the use of complexes with n = 3 and 4, suggesting that the local structure around Pd was distorted through the interaction of the Pd complexes with the pores of the FAU-zeolite. The Pd complexes included in the SC were active for allylic alkylation between allyl Me carbonate and Et acetoacetate.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Choi, Byeong-Min; Son, Seok-Hwan; Lee, Chul-Wee; Park, Sun-Yeong; Chung, Min-Chul published the article 《Characterization and synthesis of molybdenum metal precursors for hydrocracking reaction of vacuum residues》. Keywords: molybdenum metal hydrocracking reaction.They researched the compound: 1,2-Bis(diphenylphosphino)ethane( cas:1663-45-2 ).HPLC of Formula: 1663-45-2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1663-45-2) here.

In this study, Molybdenum precursors were synthesized with Triphenylphosphine, 1,2-Bis(diphenylphosphino)ethane, Pyridine, 2,2-Bipyricine as a ligands. The molybdenum precursors was used for Hydrocraking reaction of Vacuum Residue (VR). Hydrocracking reactions were carried out under the 430 °C and H2 pressure of 80 bar in an 100 mL high pressure reactor. New Molybdenum precursors were tested and their activities were compared with Mo-octoate. The Molybdeum-Phosphine precursor showed the best performances, high yield and low coke contents (below 0,5 wt%), in of hydrocracking for VR. To characterize the physicochem. properties of Moprecursor catalyst, various characterization techniques (NMR, XPS) were carried out. We confirmed that cokes in the reactor were contained the P atoms derived from ligand of Mo-precursor after hydrocracking of VR.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 14389-12-9, is researched, Molecular C6H5N5, about Solvent-dependent luminescent Cu(I) framework based on 5-(4-pyridyl)tetrazole, the main research direction is crystal structure copper pyridyltetrazole coordination polymer; copper pyridyltetrazole coordination polymer ethanol solvate preparation; luminescence copper pyridyltetrazole coordination polymer solvent dependent; solvent copper pyridyltetrazole coordination polymer fluorescence; framework polymer copper pyridyltetrazole nitrogen surface adsorption pore size.Computed Properties of C6H5N5.

A new Cu(I) coordination compound, Cu4(L)4·2EtOH (1), has been obtained from the solvothermal reaction of CuBr, 5-(4-pyridyl) tetrazole (HL), EtOH and NH3·H2O. The structure determination revealed that 1 has a 2D network, where each Cu(I) atom adopts a trigonal coordination mode. The 2D networks stacked in an ABAB sequence through the π-π interaction to form a 3D supramol. framework, giving a 1D channel along the b-axis. The TGA and powder XRD measurements revealed that the framework is stable after removal of the guest mols. Gas (N2) adsorption measurement was carried out for the framework and showed that N2 mols. cannot diffuse into the micropore and that only surface adsorption occurred. The photoluminescent study showed that compound 1 displays an interesting solvent-dependent luminescence.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Synthetic Route of C26H24P2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1,2-Bis(diphenylphosphino)ethane, is researched, Molecular C26H24P2, CAS is 1663-45-2, about The Trityl-Cation Mediated Phosphine Oxides Reduction. Author is Laye, Claire; Lusseau, Jonathan; Robert, Frederic; Landais, Yannick.

Reduction of phosphine oxides into the corresponding phosphines using PhSiH3 as a reducing agent and Ph3C+[B(C6F5)4]- as an initiator is described. The process is highly efficient, reducing a broad range of secondary and tertiary alkyl and arylphosphines, bearing various functional groups in generally good yields. The reaction is believed to proceed through the generation of a silyl cation, which reaction with the phosphine oxide provides a phosphonium salt, further reduced by the silane to afford the desired phosphine along with siloxanes.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis