Day: April 12, 2022

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 14389-12-9, is researched, SMILESS is C1(C2=NN=NN2)=CC=NC=C1, Molecular C6H5N5Journal, Polyhedron called Zeolite and sulfated zirconia as catalysts for the synthesis of 5-substituted 1H-tetrazoles via [2+3] cycloaddition of nitriles and sodium azide, Author is Teimouri, Abbas; Chermahini, Alireza Najafi, the main research direction is nitrile sodium azide cycloaddition zeolite sulfated zirconia catalyst; tetrazole green preparation.Category: chiral-nitrogen-ligands.

The [2+3] cycloaddition between various nitriles and sodium azide proceeded smoothly in the presence of zeolite and sulfated zirconia as effective catalysts, in water and DMF/MeOH, to give the corresponding 5-substituted 1H-tetrazoles in good to high yields. The reaction most probably proceeded through the in situ formation of catalyst azide species, followed by a successive [2+3] cycloaddition with the nitriles. This method has the advantages of high yields, simple methodol. and easy work-up. The catalyst can be recovered by simple filtration and reused with good yields.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Formula: C6H5N5. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 5-(4-Pyridyl)-1H-tetrazole, is researched, Molecular C6H5N5, CAS is 14389-12-9, about Ferromagnetic interaction and slow magnetic relaxation in a Co3 cluster-based three-dimensional framework. Author is Wu, Bing-Yan; Yang, Chen-I.; Nakano, Motohiro; Lee, Gene-Hsiang.

A Co3 cluster-based 3D framework, [Co3(4-ptz)4(N3)2(H2O)2].4DMF (I; 4-Hptz = 4-(1H-tetrazol-5-yl)pyridine), was prepared and its crystal and mol. structure was determined Crystal data: orthorhombic, Pnnm, a = 12.2143(13), b = 13.8051(15), c = 16.5293(17) Å, Z = 2, 2257 independent reflections, 176 refined parameters, R1 = 10390.0, wR2 = 0.2530 [I > 2σ(I)]. Compound I exhibits ferromagnetic interactions and slow-magnetic relaxation behavior.

There are many compounds similar to this compound(14389-12-9)Formula: C6H5N5. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Magyar Kemiai Folyoirat called Alkylation, transalkylation, and dealkylation of 2-amino-4-quinazolinols with amines and ammonia, Author is Lempert, Karoly; Breuer, Judit, which mentions a compound: 20198-19-0, SMILESS is O=C1NC(N)=NC2=C1C=CC=C2, Molecular C8H7N3O, Application In Synthesis of 2-Aminoquinazolin-4(3H)-one.

2-Mercapto-4-quinazolinol (1 g.) dissolved in a mixture of 10 mL. EtOH, 5 mL. H2O, and 0.33 g. KOH was treated with 0.38 mL. MeI at room temperature to yield 56.2% 2-methylthio-4-quinazolinol (I), m. 210-13°. Refluxing 1.35 g. I with 3 mL. morpholine, 1.05 mL. AcOH, and 15 mL. BuOH 45 h. gave 75% 2-morpholino-4-quinazolinol (II), m. 236-8° (BuOH). The 2-benzylamino-(III), 2-butylamino (IV), 2-amino (V) (40 h. at 120° in a sealed tube), 2-diethylaminoethylamino, and 2-anilino (VI) analogs were prepared similarly. Heating a mixture of 0.1 g. V, 1.5 mL. BuNH2, 0.42 mL. AcOH, and 10 mL. BuOH in a sealed tube at 140° 100 h. and steam distilling the product gave 40% IV, m. 184-6°. Heating a mixture of 0.7 g. III, 0.39 g. AcONH4, and 10 mL. absolute EtOH containing 0.2 g. NH3 at 140° in a sealed tube 120 h. gave 62.5% V, m. 306-8° (4:1 EtOH-HCONMe2). A mixture of 0.5 g. II, 0.33 mL. AcOH, 1.03 mL. BuNH2, and 10 mL. BuOH heated at 140° in a sealed tube 100 h. and the residue steam distilled gave 84% IV. A mixture of 0.62 g. VI, 1.43 mL. PhCH2NH2, 0.35 mL. AcOH, and 10 mL. BuOH was refluxed 90 h. and steam distilled to yield 61% III.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Design, Synthesis, and Biological Characterization of Orally Active 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors Targeting the Prevention of Osteoporosis, published in 2019-08-08, which mentions a compound: 6684-39-5, Name is 2-Chloro-5-pyridinesulfonyl chloride, Molecular C5H3Cl2NO2S, Electric Literature of C5H3Cl2NO2S.

Osteoporosis is predominantly treated with drugs that inhibit further bone resorption due to estrogen deficiency. Yet, osteoporosis drugs that not only inhibit bone resorption but also stimulate bone formation, such as potentially inhibitors of 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2), may be more efficacious in the treatment of osteoporosis. Blockade of 17β-HSD2 is thought to increase intracellular estradiol and testosterone in bone, thereby inhibiting bone resorption by osteoclasts and stimulating bone formation by osteoblasts, resp. We here describe the design, synthesis, and biol. characterization of a novel bicyclic-substituted hydroxyphenylmethanone 17β-HSD2 inhibitor (I). Compound I is a nanomolar potent inhibitor of human 17β-HSD2 (IC50 of 6.1 nM) and rodent 17β-HSD2 with low in vitro cellular toxicity, devoid of detectable estrogen receptor α affinity, displays high aqueous solubility and in vitro metabolic stability, and has an excellent oral pharmacokinetic profile for testing in a rat osteoporosis model. Administration of I in a rat osteoporosis model demonstrates its bone-sparing efficacy.

There are many compounds similar to this compound(6684-39-5)Electric Literature of C5H3Cl2NO2S. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Mackman, Richard L.; Mish, Michael; Chin, Gregory; Perry, Jason K.; Appleby, Todd; Aktoudianakis, Vangelis; Metobo, Sammy; Pyun, Peter; Niu, Congrong; Daffis, Stephane; Yu, Helen; Zheng, Jim; Villasenor, Armando G.; Zablocki, Jeff; Chamberlain, Jason; Jin, Haolun; Lee, Gary; Suekawa-Pirrone, Kimberley; Santos, Rex; Delaney, William E.; Fletcher, Simon P. researched the compound: 2-Aminoquinazolin-4(3H)-one( cas:20198-19-0 ).Name: 2-Aminoquinazolin-4(3H)-one.They published the article 《Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B》 about this compound( cas:20198-19-0 ) in Journal of Medicinal Chemistry. Keywords: CHB TLR8 agonist optimization binding HBV DNA RNA. We’ll tell you more about this compound (cas:20198-19-0).

Toll-like receptor 8 (TLR8) recognizes pathogen-derived single-stranded RNA fragments to trigger innate and adaptive immune responses. Chronic hepatitis B (CHB) is associated with a dysfunctional immune response, and therefore a selective TLR8 agonist may be an effective treatment option. Structure-based optimization of a dual TLR7/8 agonist led to the identification of the selective TLR8 clin. candidate (R)-2-((2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-ol (GS-9688, (R)-7)(I). Potent TLR8 agonism (IL-12p40 EC50 = 220 nM) and >100-fold TLR7 selectivity (IFN-α EC50 > 50μM) was observed in human peripheral blood mononuclear cells (PBMCs). The TLR8-ectodomain:(R)-7 complex confirmed TLR8 binding and a direct ligand interaction with TLR8 residue Asp545. Oral (R)-7 had good absorption and high first pass clearance in preclin. species. A reduction in viral markers was observed in HBV-infected primary human hepatocytes treated with media from PBMCs stimulated with (R)-7, supporting the clin. development of (R)-7 for the treatment of CHB.

There are many compounds similar to this compound(20198-19-0)Name: 2-Aminoquinazolin-4(3H)-one. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Ether spaced N-spirocyclic quaternary ammonium functionalized crosslinked polysulfone for high alkaline stable anion exchange membranes, published in 2020-03-15, which mentions a compound: 111-24-0, mainly applied to ether spirocyclic quaternary ammonium crosslinked polysulfone anion exchange membrane, Category: chiral-nitrogen-ligands.

N-spirocyclic cations containing anion exchange membranes (AEMs) possess excellent alk. stability, but poor mech. and conductive properties due to the rigid N-spirocyclic structure and lack of flexible side chain structural design. In this work, a flexible ether spaced N-spirocyclic quaternary ammonium functionalized side chain is proposed, in which hydroxyl substituted N-spirocyclic cation provides active grafting site with chloromethylated polysulfone through Williamson etherification. The flexible ether-oxygen spacer promotes aggregation of the rigid spirocyclic cations and thus significantly improves conductivity The uniformly in-situ thermal crosslinking between benzene rings and the residue chloromethyl groups in polysulfone greatly enhances mech. properties of the membranes. Constrained ring conformation of N-spirocyclic cation, ether spaced benzyl-free side chain, as well as the OH- blocking crosslinked networks endow an excellent alk. stability to the membranes. The ether spaced N-spirocyclic containing membranes exhibit well micro-phase separation structure, up to around 85.7 mS cm-1 of hydroxide conductivity at 80°C, around 10.5 MPa of tensile strength in hydrated state and around 95.6% conductivity retention after immersion in 1 M KOH at 80°C for 720 h. The performance is among the best N-spirocyclic functionalized AEMs reported in the literature.

There are many compounds similar to this compound(111-24-0)Category: chiral-nitrogen-ligands. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Aminoquinazolin-4(3H)-one(SMILESS: O=C1NC(N)=NC2=C1C=CC=C2,cas:20198-19-0) is researched.Recommanded Product: 111-24-0. The article 《Chemical Fragments that Hydrogen Bond to Asp, Glu, Arg, and His Side Chains in Protein Binding Sites》 in relation to this compound, is published in Journal of Medicinal Chemistry. Let’s take a look at the latest research on this compound (cas:20198-19-0).

We present an anal. of the chem. fragments from lead-like ligands in the Protein Data Bank (PDB) that form hydrogen bonds to the side chains of Asp, Glu, Arg, and His, which are the most common residues found in ligand binding sites. A fragment is defined as the largest ring assembly containing the atoms involved in hydrogen bonding. In total, 462 fragments were found in 2038 ligands from over 8000 protein-ligand structures in the PDB. The results show which fragments have a higher propensity for interaction with specific side chains. Some fragments interact with Asp but not with Glu, and vice versa, despite these side chains sharing the same chem. moiety. Arg side chains form hydrogen bonds almost exclusively with O-mediated ligands, and the fragments are the most diverse. Hydrogen bond distances from the imidazole of His showed a wider range than the other three amino acids.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Annulation of Indoles with 1,n-Dibromoalkanes by a Pd(II)-Catalyzed and Norbornene-Mediated Reaction Cascade, published in 2020-04-30, which mentions a compound: 111-24-0, mainly applied to carbazole tetrahydro preparation regioselective; dibromoalkane indole tandem cyclization palladium catalyst, Recommanded Product: 111-24-0.

By employing 1,3-dibromopropane, 1,4-dibromobutane, and 1,5-dibromopentane as biselectrophiles, the annulation of indoles I (R = H, 5-Br, 4-CN, 5-t-BuO2C, etc.) was probed in the presence of PdCl2(CH3CN)2 as a catalyst and norbornene as a transpositional ligand. Ring formation to a five-membered ring was observed at positions C2 and N, while annulation of a six-membered ring occurred at positions C2 and C3. The latter cascade process was successfully applied to the direct synthesis of 1,2,3,4-tetrahydrocarbazoles II from indoles I (11 examples, 31-68% yields). Seven-membered-ring annulation was feasible by an initial coupling at position C2 followed by alkylation at C3.

There are many compounds similar to this compound(111-24-0)Recommanded Product: 111-24-0. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Related Products of 20198-19-0. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about One-carbon compounds as synthetic intermediates. The synthesis of hydropyrimidines and hydroquinazolines by sequential nucleophilic addition to diphenyl cyanocarbonimidate with concomitant cyclization. Author is Garratt, Peter J.; Hobbs, Christopher J.; Wrigglesworth, Roger.

Di-Ph cyanocarbonimidate (PhO)2C:NCN, undergoes nucleophilic addition with ω-amino esters and amines in a sequential manner to give guanidine derivatives that, for the most part, spontaneously cyclize to give hydropyrimidines, e.g. I, or hydroquinazolines. The hydropyrimidines could be dehydrogenated to pyrimidines, and the NCN group could be hydrolyzed to a carbonyl or amine group in the pyrimidine and to an amine group in the quinazoline series. The regiospecificity of the cyclization was determined by a combination of spectroscopic methods and comparison of compounds synthesized by standard routes. The scope of the synthetic route is indicated. Some of the acyclic N-cyano-O-phenylisoureas formed by the first nucleophilic addition exist as mixtures of isomers, and the barriers to interconversion have been determined by NMR spectroscopy.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Thakur, Maheshwar S.; Nayal, Onkar S.; Rana, Rohit; Kumar, Manoranjan; Sharma, Sushila; Kumar, Neeraj; Maurya, Sushil K. published an article about the compound: 2-Aminoquinazolin-4(3H)-one( cas:20198-19-0,SMILESS:O=C1NC(N)=NC2=C1C=CC=C2 ).Application of 20198-19-0. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:20198-19-0) through the article.

A novel, mild and transition metal-free, 2-aminoquinazolin-4(3H)-one-assisted reduction of nitroarenes employing hydrazine hydrate as reducing agent and potassium carbonate as a base is reported. For the first time, the activation of hydrazine hydrate with an organocatalyst has been explored for reduction reactions. Also for the first time, 2-aminoquinazolin-4(3H)-one and its derivatives have been investigated as hydrogen bonding organocatalysts for the reduction of nitroarenes to anilines. Sensitive functional groups such as sulfonamide, carboxyl, amide and halides were well tolerated in this green methodol. with scalability and high chemoselectivity.

There are many compounds similar to this compound(20198-19-0)Application of 20198-19-0. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis