Day: April 15, 2022

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Boothello, Rio S.; Sankaranarayanan, Nehru Viji; Afosah, Daniel K.; Karuturi, Rajesh; Al-Horani, Rami A.; Desai, Umesh R. researched the compound: 1,5-Dibromopentane( cas:111-24-0 ).COA of Formula: C5H10Br2.They published the article 《Studies on fragment-based design of allosteric inhibitors of human factor XIa》 about this compound( cas:111-24-0 ) in Bioorganic & Medicinal Chemistry. Keywords: fragment based drug design coagulation factors anticoagulants heparins allosterism; Allosterism; Anticoagulants; Coagulation factors; Fragment-based drug design; Heparins. We’ll tell you more about this compound (cas:111-24-0).

Human factor XIa (hFXIa) has emerged as an attractive target for development of new anticoagulants that promise higher level of safety. Different strategies have been adopted so far for the design of anti-hFXIa mols. including competitive and non-competitive inhibition. Of these, allosteric dysfunction of hFXIa′s active site is especially promising because of the possibility of controlled reduction in activity that may offer a route to safer anticoagulants. In this work, we assess fragment-based design approach to realize a group of novel allosteric hFXIa inhibitors. Starting with our earlier discovery that sulfated quinazolinone (QAO) bind in the heparin-binding site of hFXIa, we developed a group of two dozen dimeric sulfated QAOs with intervening linkers that displayed a progressive variation in inhibition potency. In direct opposition to the traditional wisdom, increasing linker flexibility led to higher potency, which could be explained by computational studies. Sulfated QAO 19S(I) was identified as the most potent and selective inhibitor of hFXIa. Enzyme inhibition studies revealed that 19S utilizes a non-competitive mechanism of action, which was supported by fluorescence studies showing a classic sigmoidal binding profile. Studies with selected mutants of hFXIa indicated that sulfated QAOs bind in heparin-binding site of the catalytic domain of hFXIa. Overall, the approach of fragment-based design offers considerable promise for designing heparin-binding site-directed allosteric inhibitors of hFXIa.

In some applications, this compound(111-24-0)COA of Formula: C5H10Br2 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Bhattarai, Ajaya; Saha, Bidyut; Jaffari, Zeeshan Haider; Rub, Malik Abdul; Alghamdi, Yousef G.; Kumar, Dileep published the article 《Analysis of interaction between glutamic acid and ninhydrin in the presence of acetate buffer solvent: Impact of gemini (twin-headed) surfactants》. Keywords: glutamic acid ninhydrin acetate buffer gemini surfactant.They researched the compound: 1,5-Dibromopentane( cas:111-24-0 ).Recommanded Product: 111-24-0. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:111-24-0) here.

This study analyses the impact of twin-headed gemini surfactants on the interaction between glutamic acid (Glu) and a ninhydrin (Nin) in an acetate buffer. Analyses were observed using a UV-vis spectrophotometer and values of absorbance were recorded at fixed time intermissions. The impact of parameters such as pH, temperature, [Glu], and [Nin] was examined on reaction in gemini surfactants. Using a conductometric technique, elec. conductivities of pure geminis and their mixed systems were noted. Using these data, thus, cmc values of pure geminis and their mixed system were measured. By varying different parameters, the rate constant (kψ-value) was evaluated on finishing each kinetic run using a computer-based procedure. The study showed that twin-headed gemini surfactants demonstrated an excellent impact on the titled reaction over the aqueous system although 16-4-16 catalyzed the study more among geminis and followed the abilities to catalyze at each concentration as 16-4-16 > 16-5-16 > 16-6-16. Our goal was to assess the impact of varied gemini surfactants on rate constant and thus, a pseudo-phase model for micellar activity was applied. A low pos. value of ΔH# with a large neg. ΔS# was obtained in geminis than for aqueous solutions A probable reaction mechanism is discussed.

In some applications, this compound(111-24-0)Recommanded Product: 111-24-0 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Product Details of 3411-48-1. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Tri(naphthalen-1-yl)phosphine, is researched, Molecular C30H21P, CAS is 3411-48-1, about Multicomponent Reaction of Phosphines, Benzynes, and CO2: Facile Synthesis of Stable Zwitterionic Phosphonium Inner Salts. Author is Xie, Pei; Yang, Shoushan; Guo, Yuyu; Cai, Zhihua; Dai, Bin; He, Lin.

The first synthesis of benzyne-derived stable zwitterions is reported. Benzynes generated in situ from 2-(trimethylsilyl)aryl triflates undergo a multicomponent reaction with phosphines and CO2 to produce the stable 1,5-zwitterionic species in moderate to excellent isolated yields, which provides a novel method for the preparation of phosphonium inner salts, e.g. I, under mild and transition-metal-free conditions.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Computed Properties of C8H7N3O. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Regioselective synthesis of pyrimido[5,4-c][2,1]benzothiazines by reactions of β-chloroaldehydes with N-C-N binucleophiles. Author is Popov, Kirill; Volovnenko, Tatyana; Turov, Alexander; Volovenko, Yulian.

Pyrimidine ring fusion at the [c] side of benzothiazines by the reaction of 4-chloro-3,4-dihydro-1H-2,1-benzothiazine-3-carboxaldehyde S,S-dioxides with amidines was described. The formation of structural isomers of reaction products was investigated, and the regioselectivity of the heterocyclization was shown. A number of novel pyrimidobenzothiazines were synthesized.

In some applications, this compound(20198-19-0)Computed Properties of C8H7N3O is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Electron spin resonance studies of the reactions of tri(1-naphthyl)phosphine and its oxide, sulfide, and selenide with alkali metals in tetrahydrofuran and 1,2-dimethoxyethane, published in 1970, which mentions a compound: 3411-48-1, Name is Tri(naphthalen-1-yl)phosphine, Molecular C30H21P, COA of Formula: C30H21P.

Tri(1-naphthyl)phosphine (I) was treated sep. with Li, Na, K, and Na-K alloy in tetrahydrofuran (THF) and in 1,2-dimethoxyethane (DME). In both solvents, the reaction of I with Na gave the naphthalene radical anion (II) while with K (•C10H7)2PK%- (II) was formed. Reduction with Na-K alloy gave a mixture of II and III. The reaction of I with Li gave the 1,1′-binaphthyl radical anion, but when the Li was allowed to react initially with glass and then with I, the perylene radical anion was formed. The oxide, sulfide, and selenide derivatives of I all behaved similarly to I in their reactions with the alkali metals in THF and DME. The ESR spectra of the 1,1′-binaphthyl radical anion were also studied.

In some applications, this compound(3411-48-1)COA of Formula: C30H21P is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Acta Crystallographica, Section E: Structure Reports Online called trans-Carbonylchloridobis[tris(naphthalen-1-yl)phosphane-P]rhodium(I) acetone trisolvate, Author is Meijboom, Reinout, which mentions a compound: 3411-48-1, SMILESS is C1=CC2=C(C=C1)C(=CC=C2)P(C1=CC=CC2=C1C=CC=C2)C1=CC=CC2=C1C=CC=C2, Molecular C30H21P, Related Products of 3411-48-1.

In the title compound, trans-[RhCl{P(C10H7)3}2(CO)].3C3H6O, where P(C10H7)3 is trinaphthylphosphine, the Rh-P bond lengths are 2.3360. The coordination around the Rh atom shows a slightly distorted square-planar arrangement. Crystallog. data and at. coordinates are given.

In some applications, this compound(3411-48-1)Related Products of 3411-48-1 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1,2-Bis(diphenylphosphino)ethane(SMILESS: P(CCP(C1=CC=CC=C1)C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4,cas:1663-45-2) is researched.SDS of cas: 65705-44-4. The article 《Antitumor and Antiangiogenic Properties of Gold(III) Complexes Containing Cycloaurated Triphenylphosphine Sulfide Ligands》 in relation to this compound, is published in Inorganic Chemistry. Let’s take a look at the latest research on this compound (cas:1663-45-2).

A family of stable anticancer gold(III)-based therapeutic complexes containing cyclometalated triphenylphosphine sulfide ligands have been prepared The anticancer properties of the newly developed complexes [AuCl2{κ2-2-C6H4P(S)Ph2}] (1), [Au(κ2-S2CNEt2){κ2-2-C6H4P(S)Ph2}]PF6 (2), [AuCl(dppe){κC-2-C6H4P(S)Ph2}]Cl (3), and [Au(dppe){κ2-2-C6H4P(S)Ph2}][PF6]2 (4) were investigated toward five human cancer cell lines [cervical (HeLa), lung (A549), prostate (PC3), fibrosarcoma (HT1080), and breast (MDA-MB-231)]. In vitro cytotoxicity studies revealed that compounds 2-4 displayed potent cell growth inhibition (IC50 values in the range of 0.17-2.50 μM), comparable to, or better than, clin. used cisplatin (0.63-6.35 μM). Preliminary mechanistic studies using HeLa cells indicate that the cytotoxic effects of the compounds involve apoptosis induction through ROS accumulation. Compound 2 also demonstrated significant inhibition of endothelial cell migration and tube formation in the angiogenesis process. Evaluation of the in vivo antitumor activity of compound 2(I) in nude mice bearing cervical cancer cell (HeLa) xenografts indicated significant tumor growth inhibition (55%) with 1 mg/kg dose (every 3 days) compared with the same dose of cisplatin (28%). These results demonstrate the potential of gold(III) complexes containing cyclometalated triphenylphosphine sulfide ligands as novel metal-based anticancer agents. Novel cycloaurated gold(III) complexes containing triphenylphosphine sulfide ligands, exhibiting superior anticancer activities have been reported.

In some applications, this compound(1663-45-2)COA of Formula: C26H24P2 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Computed Properties of C26H24P2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1,2-Bis(diphenylphosphino)ethane, is researched, Molecular C26H24P2, CAS is 1663-45-2, about Crystal and molecular structures of some phosphane-substituted cymantrenes [(C5H4X)Mn(CO)LL′] (X = H or Cl, L = CO, L′ = PPh3 or PCy3, and LL′ = Ph2PCH2CH2PPh2). Author is Suenkel, Karlheinz; Klein-Hessling, Christian.

UV irradiation of THF solutions of [CpMn(CO)3] (Cp = π-C5H5 or π-C5H4Cl) in the presence of the phosphanes PPh3 or PCy3 (Cy = cyclohexyl) and Ph2PCH2CH2PPh2yields the substitution products [CpMn(CO)2PR3] (R = Ph or Cy) and [CpMn(CO)(Ph2PCH2CH2PPh2)], namely, dicarbonyl(η5-cyclopentadienyl)(triphenylphosphane-κP)manganese(I), [Mn(C5H5)(C18H15P)(CO)2], 1a, dicarbonyl(η5-1-chlorocyclopentadienyl)(triphenylphosphane-κP)manganese(I), [Mn(C5H4Cl)(C18H15P)(CO)2], 1b, dicarbonyl(η5-cyclopentadienyl)(tricyclohexylphosphane-κP)manganese(I), [Mn(C5H5)(C18H33P)(CO)2], 2a. Dicarbonyl(η5-1-chlorocyclopentadienyl)(tricyclohexylphosphane-κP)manganese(I), [Mn(C5H4Cl)(C18H33P)(CO)2], 2b, carbonyl(η5-cyclopentadienyl)[1,2-bis(diphenylphosphanyl)ethane-κ2P,P′]manganese(I), [Mn(C5H5)(C26H24P2)(CO)], 3a, and carbonyl(η5-1-chlorocyclopentadienyl)[1,2-bis(diphenylphosphanyl)ethane-κ2P,P′]manganese(I), [Mn(C5H4Cl)(C26H24P2)(CO)], 3b, The crystal structure determinations show a very small influence of the chlorine substitution and a moderate influence of the phosphane substitution on the bond lengths. The PR3 groups avoid being eclipsed with the C-Cl bonds. All the compounds employ weak C-H···O interactions for intermol. association, which are enhanced by C-H···Cl contacts in the chlorinated products.

In some applications, this compound(1663-45-2)Computed Properties of C26H24P2 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis, characterization, crystal structure and evaluation of four carbazole-coumarin hybrids as multifunctional agents for the treatment of Alzheimer’s disease, published in 2020-06-05, which mentions a compound: 111-24-0, Name is 1,5-Dibromopentane, Molecular C5H10Br2, Category: chiral-nitrogen-ligands.

Coupling of two distinct pharmacophores carbazole and coumarin endowed with different biol. properties afforded four hybrid compounds I [n = 3,5] and II. The structures of the carbazole-coumarin hybrids I and II were characterized by FT-IR, NMR, HRMS and single-crystal X-ray diffraction studies. All of these compounds I and II exhibited significant acetylcholinesterase inhibitory activities. Among them, compound II [n = 5] exhibited the best inhibition activity with IC50 of 3.75μM for acetylcholinesterase from elec. eel and 70.51μM for human recombinant acetylcholinesterase. Moreover, the compound I [n = 3] was showed the best antioxidant activity. The docking studies demonstrated that compound II [n = 5] could interacted with both the catalytic active site and the peripheral anionic site of acetylcholinesterase. These attributed imply carbazole-coumarin hybrids as multifunctional agents for the Alzheimer’s disease treatment.

In some applications, this compound(111-24-0)Category: chiral-nitrogen-ligands is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 5-(4-Pyridyl)-1H-tetrazole, is researched, Molecular C6H5N5, CAS is 14389-12-9, about Solid state coordination chemistry of metal-1,2,4-triazolates and the related metal-5-(pyrid-4-yl)tetrazolates.Category: chiral-nitrogen-ligands.

A review. This short review focuses on the structural chem. of the coordination polymers of 1,2,4-triazole (Htrz) and the 1,2,4-triazolate ligand (trz) and of 5-(pyrid-4-yl)tetrazolate (pt) which can be considered as an expanded analog of 1,2,4-triazolate. The structures are discussed in terms of some common building blocks and the sorptive and magnetic properties of these materials.

In some applications, this compound(14389-12-9)Category: chiral-nitrogen-ligands is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis