Day: April 19, 2022

Quality Control of Tri(naphthalen-1-yl)phosphine. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Tri(naphthalen-1-yl)phosphine, is researched, Molecular C30H21P, CAS is 3411-48-1, about C-H Bond Activation by Radical Ion Pairs Derived from R3P/Al(C6F5)3 Frustrated Lewis Pairs and N2O. Author is Menard, Gabriel; Hatnean, Jillian A.; Cowley, Hugh J.; Lough, Alan J.; Rawson, Jeremy M.; Stephan, Douglas W..

Al(C6F5)3/R3P [R = tert-Bu (tBu), mesityl (Mes), naphthyl (Nap)] frustrated Lewis pairs react with N2O to form species having the formula R3P(N2O)Al(C6F5)3, which react with addnl. alane to generate proposed frustrated radical ion pairs formulated as [R3P·][(μ-O·)(Al(C6F5)3)2] that can activate C-H bonds. For R = tBu, C-H activation of a tBu group affords [tBu2PMe(C(CH2)Me)][(μ-OH)(Al(C6F5)3)2]. In the case of R = Mes, the radical cation salt [Mes3P·][(μ-HO)(Al(C6F5)3)2] is isolated, while for R = Nap, the activation of toluene and bromobenzene gives [(Nap)3PCH2Ph][(μ-OH)(Al(C6F5)3)2] and [(Nap)3PC6H4Br][(μ-HO)(Al(C6F5)3)2], resp.

After consulting a lot of data, we found that this compound(3411-48-1)Quality Control of Tri(naphthalen-1-yl)phosphine can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Zeslawska, Ewa; Kucwaj-Brysz, Katarzyna; Kincses, Annamaria; Spengler, Gabriella; Szymanska, Ewa; Czopek, Anna; Marc, Malgorzata Anna; Kaczor, Aneta; Nitek, Wojciech; Dominguez-Alvarez, Enrique; Latacz, Gniewomir; Kiec-Kononowicz, Katarzyna; Handzlik, Jadwiga researched the compound: 1,5-Dibromopentane( cas:111-24-0 ).Quality Control of 1,5-Dibromopentane.They published the article 《An insight into the structure of 5-spiro aromatic derivatives of imidazolidine-2,4-dione, a new group of very potent inhibitors of tumor multidrug resistance in T-lymphoma cells》 about this compound( cas:111-24-0 ) in Bioorganic Chemistry. Keywords: arylpiperazinyl spiroimidazolidinedione preparation docking antitumor crystal multidrug resistance lymphoma; Crystal structure; Fluorene; Hydantoin; Multidrug resistance; P-glycoprotein (ABCB1); T-lymphoma. We’ll tell you more about this compound (cas:111-24-0).

A series of arylpiperazine derivatives of the 5-spiroimidazolidine-2,4-diones I/I·HCl (n = 3, 4, 5; R = Ph, Bn, 4-nitrophenyl, diphenylmethyl, 3-chlorophenyl), II (m = 1, 2; R1 = H, CF3) and III has been explored, including variations in the number of aromatic rings at position 5 and the length of the linker, as well as the kind and position of the linked arylpiperazine terminal fragment. Synthesis I/I·HCl and X-ray crystallog. studies for representative compounds I (n = 4; R = Bn), I·HCl (n = 3, R = Bn; n = 5, R = Ph) and II (m = 2; R1 = H (III)) have been performed. The ability to inhibit the tumor multidrug resistance (MDR) efflux pump P-glycoprotein (P-gp, ABCB1) overexpressed in mouse T-lymphoma cells was investigated. The cytotoxic and antiproliferative actions of the compounds on both the reference and the ABCB1-overproducing cells were also examined The pharmacophore-based mol. modeling studies have been performed. ADMET properties in vitro of selected most active derivatives I (n = 4; R = 4-nitrophenyl) and I·HCl (n = 3, R = Ph; n = 4, R = diphenylmethyl (IV)) have been determined All compounds, excluding III, inhibited the cancer P-gp efflux pump with higher potency than that of reference verapamil. The spirofluorene derivatives with amine alkyl substituents at position 1, and the Me group at position 3 (I/I·HCl), occurred the most potent P-gp inhibitors in the MDR T-lymphoma cell line. In particular, compounds I·HCl (n = 3; R = 4-nitrophenyl) and IV were 100-fold more potent than verapamil. Crystallog.-supported pharmacophore-based SAR anal. has postulated specific structural properties that could explain this excellent cancer MDR-inhibitory action.

After consulting a lot of data, we found that this compound(111-24-0)Quality Control of 1,5-Dibromopentane can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Carbonylation of organic halo derivatives into acids in the presence of palladium complexes, published in 1982-06-30, which mentions a compound: 3411-48-1, Name is Tri(naphthalen-1-yl)phosphine, Molecular C30H21P, SDS of cas: 3411-48-1.

The reactions of organic halides with CO to give carboxylic acids were catalyzed by the reaction products of (PhCN)2PdCl2 (I) with different ligands, e.g., phosphines, stilbines, sulfides, and quinone. Tertiary phosphines, especially Ph3P, were the most effective ligands. The activity of the halides increased in the following orders: alkyl < Ph < benzyl and Cl < Br < I. With Ph3P and I the optimal P/Pd ratio was 4-6. After consulting a lot of data, we found that this compound(3411-48-1)SDS of cas: 3411-48-1 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Electric Literature of C30H21P. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Tri(naphthalen-1-yl)phosphine, is researched, Molecular C30H21P, CAS is 3411-48-1, about Mechanistic Investigations of Reactions of the Frustrated Lewis Pairs (Triarylphosphines/B(C6F5)3) with Michael Acceptors. Author is Dupre, Jonathan; Gaumont, Annie-Claude; Lakhdar, Sami.

Frustrated Lewis pair (FLP)-catalyzed reduction of Michael acceptors is a challenging reaction that proceeds with specific FLP structures. Kinetics and equilibrium of the reactions of two phosphines (Ar3P), namely tri(1-naphthyl)phosphine and tri(o-tolyl)phosphine, are reported with reference electrophiles. The reason for the failure of the FLPs (Ar3P/B(C6F5)3) to reduce activated alkenes under H2 pressure is shown to be a hydrophosphination process that inhibits the reduction reaction. Kinetic and thermodn. factors controlling both pathways are discussed in light of Mayr’s free linear energy relationships.

After consulting a lot of data, we found that this compound(3411-48-1)Electric Literature of C30H21P can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Quantitative structure-activity study of some enzyme-inhibitory quinazolines.Name: 2-Aminoquinazolin-4(3H)-one.

Relations are formulated to explain the variation in dihydrofolate reductase [9002-03-3] inhibitory potency for a series of 25 substituted quinazolines I(R = H, OH, NH2, AcNH; R1 = H, NH2, OH, SH; R2 = H, Cl, Me; R3 = H, Me, NH2, Cl, CN, CHO, Br, CH2NH2) with an antineoplastic potential. Highly significant correlations are obtained using CNDO/2-3R calculated indexes and(or) the empirically estimated mol. polarizability as independent variables. The MO calculated indexes employed are the at. polarizability, as defined herein, and bond energy. The mol. polarizability is represented by a simple sum of environment-independent partial at. polarizabilities. The partial polarizabilities, reported here for H, C, N, O, F, S, Cl, and Br, are obtained from a multiple regression forced through the origin.

After consulting a lot of data, we found that this compound(20198-19-0)Name: 2-Aminoquinazolin-4(3H)-one can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Related Products of 20198-19-0. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Reactions of some quinazoline compounds with ethoxymethylenemalonic acid derivatives. Author is Deady, Leslie W.; Mackay, Maureen F.; Werden, Dianne M..

The reactions of Et (1,4-dihydro-4-oxoquinazolin-2-yl)acetate (I, R = CH2CO2Et) and 2-aminoquinazolin-4(1H)-one (I, R = NH2) with ethoxymethylenemalonate derivatives EtOHC:CR1R2 [R1 = R2 = CO2Et (II); R1 = CN, R2 = CN, CO2Et (III)] are reported, and different results are obtained to those previously found with quinoline analogs. Reaction of I (R = CH2CO2Et) with II gives a pyrido[1,2-a]quinazoline, while with III, 2-(pyridin-2-yl)aminobenzoates IV (R2 = CN, R3 = Et, CH2CH2CH; R2 = CO2Et, R3 = Et) are formed, presumably by ring-opening of intermediate pyrido[2,1-b]quinazolines. Reaction of I (R = NH2) with II likewise results in ultimate cyclization onto N-1 of the quinazoline, while reactions with III give isolable pyrimido[2,1-b]quinazolines. These are readily cleaved under mild conditions. The structure of IV (R2 = CN, R3 = Et) was proved by x-ray crystallog.

After consulting a lot of data, we found that this compound(20198-19-0)Related Products of 20198-19-0 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Reference of 1,2-Bis(diphenylphosphino)ethane. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1,2-Bis(diphenylphosphino)ethane, is researched, Molecular C26H24P2, CAS is 1663-45-2, about Ranking Ligands by Their Ability to Ease (C6F5)2Ni(II)L → Ni0L + (C6F5)2 Coupling versus Hydrolysis: Outstanding Activity of PEWO Ligands. Author is Ponce-de-Leon, Jaime; Gioria, Estefania; Martinez-Ilarduya, Jesus M.; Espinet, Pablo.

The NiII literature complex cis-[Ni(C6F5)2(THF)2] is a synthon of cis-Ni(C6F5)2 that allows the authors to establish a protocol to measure and compare the ligand effect on the Ni(II) → Ni(0) reductive elimination step (coupling), often critical in catalytic processes. Several ligands of different types were submitted to this Ni-meter comparison: bipyridines, chelating diphosphines, monodentate phosphines, PR2(biaryl) phosphines, and PEWO ligands (phosphines with one potentially chelate electron-withdrawing olefin). Extremely different C6F5-C6F5 coupling rates, ranging from totally inactive (producing stable complexes at room temperature) to those inducing almost instantaneous coupling at 25°, were found for the different ligands tested. The PR2(biaryl) ligands, very efficient for coupling in Pd, are slow and inefficient in Ni, and the reason for this difference was examined In contrast, PEWO type ligands are amazingly efficient and provide the lowest coupling barriers ever observed for NiII complexes; they yield up to 96% C6F5-C6F5 coupling in 5 min at 25° (the rest is C6F5H) and 100% coupling with no hydrolysis in 8 h at -22 to -53°. The ability of ligands to facilitate a difficult C-C coupling and protect from hydrolysis in Ni(II) is very different from their performance in Pd(II). Most remarkably, PR2(biaryl) ligands with very good performance in Pd(II) are not efficient in Ni(II), whereas PEWO ligands are amazingly efficient and induce C6F5-C6F5 coupling even at -50°.

After consulting a lot of data, we found that this compound(1663-45-2)Reference of 1,2-Bis(diphenylphosphino)ethane can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Condensations of isatinic acid with ureas, ethyl carbamate, and guanidine》. Authors are Stefanovic, Gj.; Lorenc, L. J.; Mihailovic, M. Lj..The article about the compound:2-Aminoquinazolin-4(3H)-onecas:20198-19-0,SMILESS:O=C1NC(N)=NC2=C1C=CC=C2).Recommanded Product: 2-Aminoquinazolin-4(3H)-one. Through the article, more information about this compound (cas:20198-19-0) is conveyed.

The title condensations gave high yields of 2-derivatives of quinazoline-4-carboxylic acid o-C6H4.N:CR’.N:CCO2R. KOH solution (20% aqueous) containing 0.1 mole KOH added to 14.7 g. isatin (II), the mixture warmed at 40° until yellow, the solution evaporated to dryness in vacuo below 40°, and the residue crystallized from EtOH gave K isatinate (III). Heating 4.06 g. III with 6.0 g. urea at 130-40° 10 hrs., treating the mixture with hot EtOH, and cooling gave 3.84 g. I(R = K, R’ = OH) (IV), which with aqueous AgNO3 was converted to I (R = Ag, R’ = OH) (V). V (2.97 g.) refluxed 6 hrs. with 2.13 g. MeI in 20 ml. anhydrous Et2O, the mixture filtered, the AgI washed with hot EtOH, the filtrate and washings combined, and evaporated to dryness in vacuo gave 2.18 g. crude I (R = Me, R’ = OH) (VI), m. 200-1° (EtOH). When anhydrous MeOH was used for washing and crystallization, VI crystallized with 1 mol. MeOH, m. 216°. IV (9.1 g.) in 90 ml. H2O treated at 5° with an equivalent amount of 8% aqueous HCl, the precipitate filtered off, and washed with cold H2O gave 7.5 g. I (R = H, R’ = OH) (VII).H2O, m. 264-5°, pK 3.10 (H2O-EtOH), which gave the anhydrous acid (VIII) on prolonged drying over P2O5 in vacuo. This (2.08 g.) treated dropwise with excess CH2N2 in anhydrous Et2O at ice-bath temperature gave, after evaporation of solvent, crude I (R = Me, R’ = OMe) (IX), m. 99-100° (EtOH). IX (240 mg.) refluxed 30 min. with 12 ml. 0.1N aqueous NaOH, the solution cooled to 5°, acidified with 5% aqueous HCl to Congo red, and filtered gave 190 mg. I (R = H, R’ = OMe) (X), m. 156° (purification through the Na salt). X (102 mg.) heated at 160° to cessation of CO2 evolution and the product sublimed at 10-15 mm. gave 48.2 mg. 2-methoxyquinazoline, m. 56°. Boiling 7.50 g. VIII in 75 ml. H2O 6 hrs., cooling, and filtering gave 5.0 g. crude 2-quinazolone (XI), converted to the hydrochloride, m. above 300°, by boiling concentrated HCl and addition of EtOH. This gave pure XI, m. 282-4°, with boiling EtOH. III (10.15 g.) heated with (H2N)2C:NH 4 hrs. at 125°, followed by dissolution with H2O, filtration, and acidification of the filtrate with 5% aqueous HCl to Congo red gave 8.9 g. I (R = H, R’ = NH2) (XII), which, after solution in NaHCO3 and precipitation with 5% sq. HCl, gave pure XII, m. 210°. Treating XII at 5° in Et2O with a slight excess of ethereal CH2N2, evaporating the solvent, and crystallizing the crude product from EtOH gave I (R = Me, R’ = NH2) (XIII), m. 144-5°. XII (100 mg.) decarboxylated at 220-5°/10-15 mm. yielded 63 mg. 2-aminoquinazolone, m. 205°, which sublimed during the decarboxylation. IV was also obtained in high yield by reaction of PhNHCONH2, Me2NCONH2, or NH2CO2Et with III. A discussion of lactim-lactam tautomerization was given, based on the methylation reactions and infrared spectra.

After consulting a lot of data, we found that this compound(20198-19-0)Recommanded Product: 2-Aminoquinazolin-4(3H)-one can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 14389-12-9, is researched, Molecular C6H5N5, about Unprecedented Application of Flexible Bis(pyridyl-tetrazole) Ligands To Construct Helix/Loop Subunits To Modify Polyoxometalate Anions, the main research direction is silver pyridyltetrazole molybdophosphate tungstophosphate polyoxometalate preparation structure electrochem catalyst; electrocatalyst photocatalyst silver pyridyltetrazole molybdophosphate tungstophosphate; crystal structure silver pyridyltetrazole molybdophosphate tungstophosphate dimer coordination polymer.Application of 14389-12-9.

By introducing the unprecedented and flexible isomeric bis(pyridyl-tetrazole) ligands into a polyoxometalates (POMs) system, three POM-based compounds, {Ag2(4-bptzb)2(H2O)2[H2PMo12O40]2}·4-bptzb·5H2O (1), [Ag4(3-bptzb)2(PMoVMoVI11O40)]·2H2O (2), and Ag3(3-bptzb)2.5(H2O)2[H3P2W18O62] (3) [4-bptzb = 1,4-bis(5-(4-pyridyl)tetrazol-2-yl)butane and 3-bptzb = 1,4-bis(5-(3-pyridyl)tetrazol-2-yl)butane], were synthesized under hydrothermal conditions and structurally characterized by single-crystal x-ray diffraction analyses. Compound 1 exhibits a dimeric structure constructed from two Keggin [PMo12O40]3- anions and a binuclear [Ag2(trans-4-bptzb)2]2+ subunit in which the trans-4-bptzb acts as a bidentate bridging ligand with one tetrazolyl group. In 2, the 3-bptzb acts as a tetradentate bridging ligand with the tetrazolyl and pyridyl groups linking AgI ions to generate a 3D metal-organic framework (MOF), which contains charming meso-helix chains. The Keggin anions acting as bidentate inorganic ligands reside in the distorted tetragonal channels of the MOF. In compound 3, the 3-bptzb adopts versatile coordination modes linking AgI ions to first construct loop connecting loop 1D chains, which are linked by {Ag[P2W18O62]}n zigzag chains to form a scarce hamburger-style 2D sheet. These adjacent sheets are further fused by 3-bptzb ligands to construct a 3D framework. The influences of isomeric bptzb ligands and POMs on the construction of Ag-bptzb subunits and the whole structures of the title compounds are discussed. The electrochem. behaviors and electrocatalytic activities of compounds 2 and 3 and their corresponding parent POMs as well as the fluorescent properties of the title compounds were studied. The photocatalytic activities of compounds 2 and 3 and their corresponding parent POMs for decomposition of methylene blue, rhodamine B, and Methyl orange under UV irradiation also were investigated.

After consulting a lot of data, we found that this compound(14389-12-9)Application of 14389-12-9 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Computed Properties of C30H21P. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Tri(naphthalen-1-yl)phosphine, is researched, Molecular C30H21P, CAS is 3411-48-1, about Selective hydroformylation of 1-hexene to branched aldehydes using rhodium complex of modified bulky phosphine and phosphite ligands.

The selective hydroformylation of 1-hexene to branched aldehydes was investigated using rhodium complex of tri-1-naphthylphosphine PNp3 and tri-1-naphthylphosphite P(ONp)3. The PNp3 and P(ONp)3 ligands having more steric nature than PPh3 enhanced the formation of branched aldehydes at 110 °C and 4.0 MPa syngas pressure. The branched aldehyde selectivity increased remarkably (82%) by adding P(ONp)3 as auxiliary ligand in Rh/PNp3 catalyzed hydroformylation of 1-hexene. The high selectivity for the branched aldehydes is due to rapid alkene isomerization producing internal alkenes followed by hydroformylation to yield branched aldehydes.

After consulting a lot of data, we found that this compound(3411-48-1)Computed Properties of C30H21P can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis