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Rate constants of the proton transfer reactions RH+ + DMP ? R + DMP·H+, where R was acetone (Ac), trimethyl amine (TMA) or H2O and DMP was 2,4-dimethyl pyridine have been measured by ion mobility spectrometry (IMS). The Reactant R was injected into the ionization region of IMS to produce RH+ while DMP was continuously delivered to the drift region to react with the RH+ pulsed into the drift tube by a shutter grid. Since DMP.H+ was generated along the drift tube, a tail appeared in the IMS spectrum that contained kinetic information. To prevent proton-bound dimer formation, the reactions were carried out at elevated temperatures (170-230 C). We measured rate constants of 1.17 × 10-9, 0.90 × 10-9 and 0.68 × 10-9 cm3 s-1 for proton transfer from H3O +, Ac·H+ and TMA·H+ to DMP, respectively. The experimental rate constants were almost temperature independent, indicating that no activation energy was involved in those proton transfer reactions. The rate constants were also calculated by using average dipole orientation (ADO) theory at B3LYP and MP2 levels. The calculated values revealed acceptable agreement between the experimental and theoretical trends. 2014 Elsevier B.V.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 108-47-4 is helpful to your research. Synthetic Route of 108-47-4
Reference：
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis