In an article, author is Luo, Weiwei, once mentioned the application of 131-53-3, Formula: C14H12O4, Name is Dioxybenzone, molecular formula is C14H12O4, molecular weight is 244.24, MDL number is MFCD00002218, category is chiral-nitrogen-ligands. Now introduce a scientific discovery about this category.
Formal oxo- and aza-[3+2] reactions of aenaminones and quinones: a double divergent process and the roles of chiral phosphoric acid and molecular sieves
A double divergent process has been developed for the reaction of alpha-enaminones with quinones through facile manipulation of catalyst and additive, leading to structurally completely different products. The two divergent processes, which involve formal aza- and oxo-[3 + 2] cycloaddition reactions, are mediated by chiral phosphoric acid and molecular sieves, respectively. While inclusion of phosphoric acid in the reaction switched the reaction pathway to favor the efficient formation of a wide range of N-substituted indoles, addition of 4 angstrom molecular sieves to the reaction switched the reaction pathway again, leading to enantioselective synthesis of 2,3-dihydrobenzofurans in excellent yields and enantioselectivities under mild conditions. Studies in this work suggest that the chiral phosphoric acid acts to lower the transition state energy and promote the formation of amide intermediate for the formal aza-[3 + 2] cycloaddition and the molecular sieves serve to facilitate proton transfer for oxo-[3 + 2] cycloaddition. The reactivity of alpha-enaminones is also disclosed in this work.
If you are interested in 131-53-3, you can contact me at any time and look forward to more communication. Formula: C14H12O4.
Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
,Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis