Synthetic Route of 4767-03-7, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 4767-03-7, Name is 3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoic acid, SMILES is O=C(O)C(C)(CO)CO, belongs to chiral-nitrogen-ligands compound. In a article, author is Li, Hanyuan, introduce new discover of the category.
Enantioselective [4+1]-Annulation of alpha,beta-Unsaturated Imines with Allylic Carbonates Catalyzed by a Hybrid P-Chiral Phosphine Oxide-Phosphine
A highly enantio- and diastereoselective [4 + 1]-annulation reaction between alpha,beta-unsaturated imines and allylic carbonates has been realized under the catalysis of a novel hybrid P-chiral phosphine oxide-phosphine, providing enantioenriched polysubstituted 2-pyrrolines in good to excellent yields and up to 99% ee. Based on Han’s methods, the catalyst featuring a sole P(O)-chirality in the molecule is readily accessible and represents a class of new chiral phosphine organocatalysts. In the plausible catalytic mechanism, art intramolecular Coulombic interaction between the in situ generated phosphonium cation and polar chiral P=O moiety may play a positive role.
Synthetic Route of 4767-03-7, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 4767-03-7 is helpful to your research.
Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
,Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis