Chemistry, like all the natural sciences, Recommanded Product: DL-2,3-Dihydroxy-1,4-butanedithiol, begins with the direct observation of nature¡ª in this case, of matter.3483-12-3, Name is DL-2,3-Dihydroxy-1,4-butanedithiol, SMILES is O[C@@H]([C@H](O)CS)CS, belongs to chiral-nitrogen-ligands compound. In a document, author is Aota, Yusuke, introduce the new discover.
Asymmetric Synthesis of Chiral Sulfoximines through the S-Alkylation of Sulfinamides
Innovation in drug discovery critically depends on the development of new bioisosteric groups. Chiral sulfoximines, which contain a tetrasubstituted sulfur atom that bears one nitrogen, one oxygen, and two different carbon substituents, represent an emerging chiral bioisostere in medicinal chemistry. Chiral sulfoximines are conventionally prepared by a stereospecific nitrene transfer reaction to chiral sulfoxides; however, the number of readily available chiral sulfoxides remains limited. Herein, we report the asymmetric synthesis of a class of hitherto difficult-to-access chiral sulfoximines with two structurally similar alkyl chains. Our synthetic approach is based on the sulfur-selective alkylation of easily accessible chiral sulfinamides with commercially available reagents under simple and safe conditions. This stereospecific S-alkylation offers a general and scalable approach to the asymmetric synthesis of chiral sulfoximines, which represent important substructures in bioactive molecules.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 3483-12-3. Recommanded Product: DL-2,3-Dihydroxy-1,4-butanedithiol.
Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
,Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis