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The present invention discloses a hand natural uncleding Ya sulfonamide synthesis process. Taking tert butyl mercaptan with iodine/hydrogen peroxide in acetone butadiene-butyl disulfide, then under the catalysis of the oxidation of hydrogen peroxide in vanadiumchiral unclesulfur alcohol esterbutyl Asia sulfonyl bi, then in the presence of chlorine, liquid ammonia/lithium reagent with a one-pot reaction to obtain the uncle butyl Asia sulfonamide. This technology compared with the prior process, the fluency enhancing process, liquid ammonia consumption can be greatly reduced, operation efficiency is improved. (by machine translation)

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis