Recommanded Product: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol, Chemical engineers ensure the efficiency and safety of chemical processes, adapt the chemical make-up of products to meet environmental or economic needs, and apply new technologies to improve existing processes. 126456-43-7, Name is (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol,belongs to chiral-nitrogen-ligands compounds, now introducing its new discovery.
A chiral ruthenium catalyst was developed for the enantioselective sulfoxidation of the title compounds. The catalyst combines two elements of chirality, a chiral pybox ligand and a chiral bicylic lactam unit, to which the ligand is attached. The latter unit was shown to improve significantly the performance of the catalyst by exposing one of the two enantiotopic sulfur atoms to the active site via hydrogen-bond mediated coordination. Ten differently substituted substrates were converted into the respective sulfoxides in yields of 52-71% and with ?90% ee. Hand-in-hand: Two spatially remote chiral entities act synergistically together in the Ru-catalyzed sulfoxidation reaction of the title compounds. Hydrogen bonds and pi-pi interactions are invoked to explain the preferential formation of a single stereoisomer in this reaction. High enantioselectivities (90-99% ee).
The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.I hope my blog about 126456-43-7 is helpful to your research. Recommanded Product: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol
Reference：
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis