COA of Formula: C26H24P2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1,2-Bis(diphenylphosphino)ethane, is researched, Molecular C26H24P2, CAS is 1663-45-2, about The palladacycle, BTC2, exhibits anti-breast cancer and breast cancer stem cell activity. Author is Kimani, Serah; Chakraborty, Suparna; Irene, Ikponmwosa; de la Mare, Jo; Edkins, Adrienne; du Toit, Andre; Loos, Ben; Blanckenberg, Angelique; Van Niekerk, Annick; Costa-Lotufo, Leticia V.; ArulJothi, KN.; Mapolie, Selwyn; Prince, Sharon.
In women globally, breast cancer is responsible for most cancer-related deaths and thus, new effective therapeutic strategies are required to treat this malignancy. Platinum-based compounds like cisplatin are widely used to treat breast cancer, however, they come with limitations such as poor solubility, adverse effects, and drug resistance. To overcome these limitations, complexes containing other platinum group metals such as palladium have been studied and some have already entered clin. trials. Here we investigated the anti-cancer activity of a palladium complex, BTC2, in MCF-7 estrogen receptor pos. (ER+) and MDA-MB-231 triple neg. (TN) human breast cancer cells as well as in a human breast cancer xenograft chick embryo model. BTC2 exhibited an average IC50 value of 0.54μM, a desirable selectivity index of >2, inhibited the migration of ER+ and TN breast cancer cells, and displayed anti-cancer stem cell activity. We demonstrate that BTC2 induced DNA double strand breaks (increased levels of γ-H2AX) and activated the p-ATM/p-CHK2 and p-p38/MAPK pathways resulting in S- and G2/M-phase cell cycle arrests. Importantly, BTC2 sensitized breast cancer cells by triggering the intrinsic (cleaved caspase 9) and extrinsic (cleaved caspase 8) apoptotic as well as necroptotic (p-RIP3 and p-MLKL) cell death pathways and inhibiting autophagy and its pro-survival role. Furthermore, in the xenograft in vivo model, BTC2 displayed limited toxicity and arrested the tumor growth of breast cancer cells over a 9-day period in a manner comparable to that of the pos. control drug, paclitaxel. BTC2 thus displayed promising anti-breast cancer activity.
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Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis