So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Al-Janabi, Emaad M. A.; Hatshan, Mohammad R.; Adil, Syed Farooq; Kadhum, Wesam R.; Al-Jibori, Subhi A.; Faihan, Ahmed S.; Al-Janabi, Ahmed S. researched the compound: 1,2-Bis(diphenylphosphino)ethane( cas:1663-45-2 ).Synthetic Route of C26H24P2.They published the article 《Spectroscopic, antibacterial and anti-cancer studies of new platinum(II)-diethyldithiocarbamate mixed ligand complexes with phosphine or amine ligands》 about this compound( cas:1663-45-2 ) in Journal of Molecular Structure. Keywords: platinum diethyldithiocarbamate phosphine amine complex preparation antibacterial antitumor activity. We’ll tell you more about this compound (cas:1663-45-2).
A series of new platinum(II) mixed ligand complexes of diethyldithiocarbamate (Et2DT) and phosphine or amine ligands of the type [Pt(Et2DT)2(diphosphine)] (3-6), [Pt(Et2DT)2(diamine)](7-8), [Pt(Et2DT)2(PPh3)2] (9) and [Pt(Et2DT)2(SPPh3)2](10) have been prepared in good yield and fully characterized by elemental anal., conductivity measurements and spectroscopic data (i.r., 1H, 31P-{1H} nmr). Our interest in these types of complexes are based on the fact that these complexes are known for their promising biol. activity, and could possess interesting coordination modes, which are poorly represented in the literature. Therefore, the prepared complexes were tested for their anti-bacterial against three types of pathogenic bacteria namely S. aureus, E. coli, and p. aeruginosa. In addition, four of the prepared complexes were screened for their anti-cancer activity against lung cancer cell lines, and that the [Pt(Et2DT)2(bipy)] was significantly more potent with IC50 value is 1.0 ± 0.2μM, but the [Pt(Et2DT)2(dppf)] was practically inactive in the selected dose range with IC50 value is 32.0 ± 3.0μM.
As far as I know, this compound(1663-45-2)Synthetic Route of C26H24P2 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis