Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 20198-19-0, is researched, SMILESS is O=C1NC(N)=NC2=C1C=CC=C2, Molecular C8H7N3OJournal, Khimiya Geterotsiklicheskikh Soedinenii called Acylation of 2-amino-4-quinazolones unsaturated acyl chlorides, Author is Yun, L. M.; Nazhimov, K. O.; Masharipov, S.; Samiev, R. A.; Makhmudov, S. A.; Kasymova, S. S.; Vergizov, S. N.; V’yunov, K. A.; Shakhidoyatov, Kh. M., the main research direction is acylation aminoquinazolone unsaturated chloride; pyrimidoquinazolinedione; quinazolone amino acylation unsaturated chloride.Safety of 2-Aminoquinazolin-4(3H)-one.
Condensation of quinazolone I by R1CH:CRCOCl (R = Me, R1 = H; R = H, R1 = Me, Ph) in DMF containing Et3N gave 36-70% acylated derivatives II which (R = Me, R1 = H) underwent intramol. cycloaddition at 250-260° to give 43% pyrimidoquinazolinedione III. Addnl. acylations of the 2-Me derivative of I gave 15-49% quinazolones IV.
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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis