The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Tri(naphthalen-1-yl)phosphine(SMILESS: C1=CC2=C(C=C1)C(=CC=C2)P(C1=CC=CC2=C1C=CC=C2)C1=CC=CC2=C1C=CC=C2,cas:3411-48-1) is researched.Recommanded Product: 2-Aminoquinazolin-4(3H)-one. The article 《Hydrogenation of Secondary Amides using Phosphane Oxide and Frustrated Lewis Pair Catalysis》 in relation to this compound, is published in Chemistry – A European Journal. Let’s take a look at the latest research on this compound (cas:3411-48-1).
The metal-free catalytic hydrogenation of secondary amides for synthesis of amines RCH2NHR1 [R = i-Pr, Ph, 4-BrC6H4, etc.; R1 = Me, Et, Ph, etc.] was developed. The reduction was realized by two new catalytic reactions. First, the amide was converted into the imidoyl chloride by triphosgene (CO(OCCl3)2) using novel phosphorus(V) catalysts. Second, the in situ generated imidoyl chlorides were hydrogenated in high yields by an FLP-catalyst. Mechanistic and quantum mech. calculations supported an autoinduced catalytic cycle for the hydrogenation with chloride acting as unusual Lewis base for FLP-mediated H2-activation.
In addition to the literature in the link below, there is a lot of literature about this compound(Tri(naphthalen-1-yl)phosphine)Application In Synthesis of Tri(naphthalen-1-yl)phosphine, illustrating the importance and wide applicability of this compound(3411-48-1).
Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis