Reference of 2-Aminoquinazolin-4(3H)-one. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Quinazolines as inhibitors of dihydrofolate reductase. 1.
2,4-Diaminoquinazolines were potent in vitro inhibitors of rat liver dihydrofolate reductase [9002-03-3]. The most potent compound, 6-bromo-5-chloro-2,4-diaminoquinazoline (I) [41934-85-4], produced 50% inhibition at 0.10 μM, and was thus nearly as effective an inhibitor as pyrimethamine. I was prepared from 5-chloro-2,4,6-triaminoquinazoline [17511-20-5] by diazotization of the 6-amino group in 2N MeSO3H and reaction with CuBr in 50% HBr.
Although many compounds look similar to this compound(20198-19-0)Reference of 2-Aminoquinazolin-4(3H)-one, numerous studies have shown that this compound(SMILES:O=C1NC(N)=NC2=C1C=CC=C2), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis