The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 3896-11-5, Name is 2-(tert-Butyl)-6-(5-chloro-2H-benzo[d][1,2,3]triazol-2-yl)-4-methylphenol, SMILES is CC1=CC(=C(O)C(=C1)N1N=C2C=CC(Cl)=CC2=N1)C(C)(C)C, in an article , author is Ma, Chunying, once mentioned of 3896-11-5, COA of Formula: C17H18ClN3O.
Diastereoselective Synthesis of Vicinal Diamines by Aza-Michael Addition of Chiral Phenethylamine to Nitroalkenes
An efficient aza-Michael addition of (R or S)-alpha-phenethylamine, a chiral nitrogen nucleophile to (E)-nitroalkenes 2a-f permits the synthesis of vicinal diamines (or 1, 2-di-amine) after reduction of the 1, 4-adducts 3a-f (or 3’a-f). The key adducts 3 a-f (or 3’a-f) can be obtained in good yields (up to 78%) and excellent diastereoselectivities (up to = 98:2 dr (diastereomeric excess ratio)). In addition, this is one of the scarce examples where chiral phenethylamine and nitroalkenes have been used in catalyst-free aza-Michael additions. Our developed strategy opens an efficient entry to synthetic building blocks of vicinal diamines for natural products and drugs.
Interested yet? Read on for other articles about 3896-11-5, you can contact me at any time and look forward to more communication. COA of Formula: C17H18ClN3O.
Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
,Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis