Product Details of 6684-39-5. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Chloro-5-pyridinesulfonyl chloride, is researched, Molecular C5H3Cl2NO2S, CAS is 6684-39-5, about A reversed sulfonamide series of selective RORc inverse agonists. Author is van Niel, Monique B.; Fauber, Benjamin P.; Cartwright, Matthew; Gaines, Simon; Killen, Jonathan C.; Rene, Olivier; Ward, Stuart I.; de Leon Boenig, Gladys; Deng, Yuzhong; Eidenschenk, Celine; Everett, Christine; Gancia, Emanuela; Ganguli, Arunima; Gobbi, Alberto; Hawkins, Julie; Johnson, Adam R.; Kiefer, James R.; La, Hank; Lockey, Peter; Norman, Maxine; Ouyang, Wenjun; Qin, Ann; Wakes, Nicole; Waszkowycz, Bohdan; Wong, Harvey.
The identification of a new series of RORc inverse agonists is described. Comprehensive structure-activity relationship studies of this reversed sulfonamide series identified potent RORc inverse agonists in biochem. and cellular assays which were also selective against a panel of nuclear receptors. The work has contributed a compound that may serve as a useful in vitro tool to delineate the complex biol. pathways involved in signaling through RORc. An x-ray cocrystal structure of an analog with RORc has also provided useful insights into the binding interactions of the new series.
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Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis