So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Chermahini, Alireza Najafi; Teimouri, Abbas; Momenbeik, Fariborz; Zarei, Amin; Dalirnasab, Zeinab; Ghaedi, Aseyeh; Roosta, Mostafa researched the compound: 5-(4-Pyridyl)-1H-tetrazole( cas:14389-12-9 ).COA of Formula: C6H5N5.They published the article 《Clay-catalyzed synthesis of 5-substituent 1-H-tetrazoles》 about this compound( cas:14389-12-9 ) in Journal of Heterocyclic Chemistry. Keywords: aryl substituted tetrazole preparation; arylnitrile sodium azide cycloaddition clay. We’ll tell you more about this compound (cas:14389-12-9).
In this study, the possibility of 5-substituted 1-H-tetrazoles synthesis using clays as catalyst was investigated. The reaction of a series of aromatic nitriles with sodium azide was catalyzed by montmorillonite K-10 or kaolin clays in water or DMF as solvent. Conventional heating or ultrasonic irradiation was used to promote reaction. The amount of nitrile to sodium azide mole ratio, amount of catalyst, reaction time, and solvent type were optimized. The versatility of this method was checked by using various nitriles, which showed reasonable yields of tetrazole formation. It was found that using nitriles with electron-withdrawing groups result in both higher yields and lower reaction times. The catalysts could be reused several times without significant loss of their catalytic activity. Compared to conventional heating, ultrasonic irradiation reduced reaction times and increased catalyst activity. The present procedure is green and offers advantages, such as shorter reaction time, simple workup, and recovery and reusability of catalyst. J. Heterocyclic Chem., (2010).
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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis