A common heterocyclic compound, the chiral-nitrogen-ligands compound, name is N1,N2-Dimethylethane-1,2-diamine,cas is 110-70-3, mainly used in chemical industry, its synthesis route is as follows.
110-70-3, beta-CD-OTs (500.0 mg, 0.388 mmol) was dissolved in 5 mL dry DMF with 100 mg NaI. N,N?-Dimethylethane-1,2-diamine (1.28 mL, 11.72 mmol) was then added under N2 and the reaction mixture was stirred overnight at 70 C. under N2. The next day the reaction mixture was cooled and precipitated in 50 mL acetone, giving a white precipitate. Unreacted tosylate was removed via the same ion-exchange methods as described above for beta-CD-NH2. Yield=374 mg (80.0%). 1H NMR (300 MHz, D2O, delta): 5.02-4.87 (s, 7H, C1H of CD), 3.93-3.64 (m, 29H, C2H, C3H, C4H, and C5H of CD and NH), 3.61-3.29 (m, 14H, C6H of CD), 3.01-2.36 (m, 10H, N1-CH2, N2-CH2, and N2-(CH3)2).
As the rapid development of chemical substances, we look forward to future research findings about 110-70-3
Reference£º
Patent; Thompson, David H.; Kulkarni, Aditya; Deng, Wei; US2015/202323; (2015); A1;,
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis