The chiral-nitrogen-ligands compound, name is (R)-(+)-N,N-Dimethyl-1-ferrocenylethylamine,cas is 31886-58-5, mainly used in chemical industry, its synthesis route is as follows.
b) Preparation of L (mixture of diastereomers); To a solution of 5.98 g (23.2 mmol) of (R)-1-dimethylamino-1 -ferrocenylethane in 40 ml of diethyl ether (DE) are added dropwise, at <-10C, 15.5 ml (23.2 mmol) of t-butyllithium (t-BuLi) (1.5 M in pentane). After stirring at the same temperature for 10 minutes, the temperature is allowed to rise to room temperature and the mixture is stirred for another 1.5 hours. This affords a solution of compound X2 which is added via a cannula to the cooled suspension of the monochlorophosphine X1 at a sufficiently slow rate that the temperature does not rise above -300C. After stirring at -300C for a further 10 minutes, the temperature is allowed to rise to 0C and the mixture is stirred at this temperature for another 2 hours. The reaction mixture is admixed with 20 ml of water. The organic phase is removed and dried over sodium sulphate, and the solvent is distilled off under reduced pressure on a rotary evaporator. After chromatographic purification (silica gel 60; eluent = 85:10:5 heptane/ethyl acetate/thethylamine), 11.39 g of the desired product are obtained as a mixture of 2 diastereomers.
As the rapid development of chemical substances, we look forward to future research findings about 31886-58-5
Reference£º
Patent; SPEEDEL EXPERIMENTA AG; WO2008/77917; (2008); A1;,
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis