Related Products of 131-53-3, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 131-53-3, Name is Dioxybenzone, SMILES is O=C(C1=CC=C(OC)C=C1O)C2=CC=CC=C2O, belongs to chiral-nitrogen-ligands compound. In a article, author is Wang, Mei-Xin, introduce new discover of the category.
Enantioselective synthesis of chiral alpha-alkynylated thiazolidones by tandem S-addition/acetalization of alkynyl imines
A SPINOL-derived chiral phosphoric acid catalyzed asymmetric formal [2 + 3]-annulation of in situ generated alkynyl imines and 1,4-dithiane-2,5-diol has been developed to afford enantiopure alpha-alkynylated thiazolidones with up to 72% yield and 98.5 : 1.5 er. This tandem annulation involved a tandem S-addition of alkynyl imines/intramolecular acetalization, followed by PDC-mediated oxidation. The alpha-alkynylated thiazolidones could facilely afford the corresponding chiral alpha-alkynylated or alpha-alkenylated cyclic sulfoxides via further elaboration.
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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
,Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis