Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Amabili, Paolo, once mentioned the application of 131-53-3, Name is Dioxybenzone, molecular formula is C14H12O4, molecular weight is 244.24, MDL number is MFCD00002218, category is chiral-nitrogen-ligands. Now introduce a scientific discovery about this category, Formula: C14H12O4.
Synthesis of Enantiopure Isosteres of Amino Acids Containing a Quaternary Stereocenter: Experimental and Computational Evaluation of a Novel Class of Atropisomers
Electrophilic amination of diastereomeric 4-methoxycarbonyl pyrrolidin-2-ones allowed to prepare both diastereomers of an amino acid bearing a quaternary chiral center, a key intermediate to antibiotic 8-methoxyquinolone carboxylic acid. Within this synthesis, novel atropisomers, exceedingly stable at room temperature, were isolated and characterized, which were subsequently converted into the desired products by a novel reductive N-N bond cleavage reaction.
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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
,Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis