Reference of 1,2-Bis(diphenylphosphino)ethane. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1,2-Bis(diphenylphosphino)ethane, is researched, Molecular C26H24P2, CAS is 1663-45-2, about Ranking Ligands by Their Ability to Ease (C6F5)2Ni(II)L → Ni0L + (C6F5)2 Coupling versus Hydrolysis: Outstanding Activity of PEWO Ligands. Author is Ponce-de-Leon, Jaime; Gioria, Estefania; Martinez-Ilarduya, Jesus M.; Espinet, Pablo.
The NiII literature complex cis-[Ni(C6F5)2(THF)2] is a synthon of cis-Ni(C6F5)2 that allows the authors to establish a protocol to measure and compare the ligand effect on the Ni(II) → Ni(0) reductive elimination step (coupling), often critical in catalytic processes. Several ligands of different types were submitted to this Ni-meter comparison: bipyridines, chelating diphosphines, monodentate phosphines, PR2(biaryl) phosphines, and PEWO ligands (phosphines with one potentially chelate electron-withdrawing olefin). Extremely different C6F5-C6F5 coupling rates, ranging from totally inactive (producing stable complexes at room temperature) to those inducing almost instantaneous coupling at 25°, were found for the different ligands tested. The PR2(biaryl) ligands, very efficient for coupling in Pd, are slow and inefficient in Ni, and the reason for this difference was examined In contrast, PEWO type ligands are amazingly efficient and provide the lowest coupling barriers ever observed for NiII complexes; they yield up to 96% C6F5-C6F5 coupling in 5 min at 25° (the rest is C6F5H) and 100% coupling with no hydrolysis in 8 h at -22 to -53°. The ability of ligands to facilitate a difficult C-C coupling and protect from hydrolysis in Ni(II) is very different from their performance in Pd(II). Most remarkably, PR2(biaryl) ligands with very good performance in Pd(II) are not efficient in Ni(II), whereas PEWO ligands are amazingly efficient and induce C6F5-C6F5 coupling even at -50°.
After consulting a lot of data, we found that this compound(1663-45-2)Reference of 1,2-Bis(diphenylphosphino)ethane can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis