The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Synthesis of imidazopyrimidines and imidazoquinazolines with a common nitrogen atom, the main research direction is imidazopyrimidine; imidazoquinazoline; cyclocondensation ketone aminopyrimidine aminoquinazoline; pyrimidine amino cyclocondensation ketone; quinazoline amino cyclocondensation ketone.Application of 20198-19-0.
Condensing 2-aminopyrimidine with RCOCHBrR1 (I; R = alkyl aryl, heterocyclyl; R1 = H, alkyl) gave 50-99% imidazopyrimidines II. Thus, 2-amino-4-hydroxy-6-methylpyrimidine and BrCH2COC6H4NO2-p gave 80% III and 18% IV. Similarly, 4-aminopyrimidine V (R2 = H, MeO; R3 = Cl, MeO) with I gave 68-90% VI. The analogous reaction of 2-chloro- or 2-amino-4-quinazolone or 4-aminoquinazoline gave 41-99% VII (R = alkyl, aryl; R1 = H, alkyl; R2 = H, alkyl, aryl) and 47-88% VIII (R = alkyl, aryl, heterocyclyl; R1 = H, alkyl), resp. Hydrolysis of VIII (R = p-BrC6H4, R1 = H) gave 1-(p-bromophenacyl)-1,4-dihydroquinazolin-4-one. 4-Quinazolone and p-BrC6H4COCH2Br gave 3-(p-bromophenacyl)-3,4-dihydroquinazolin-4-one.
Compounds in my other articles are similar to this one(2-Aminoquinazolin-4(3H)-one)Application of 20198-19-0, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.
Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis