In an article, author is Chen, Xu, once mentioned the application of 937-30-4, Recommanded Product: 4-Ethylacetophenone, Name is 4-Ethylacetophenone, molecular formula is C10H12O, molecular weight is 148.2017, MDL number is MFCD00009262, category is chiral-nitrogen-ligands. Now introduce a scientific discovery about this category.
Cobalt-Catalyzed Asymmetric Markovnikov Hydroboration of Styrenes
A cobalt-catalyzed asymmetric hydroboration of styrenes using an imidazoline phenyl picoliamide (ImPPA) ligand was first reported to deliver the valuable chiral secondary organoboronates with good functional tolerance and high enantioselectivity (up to >99% ee). This protocol is operationally simple without any activator. Particularly, this method can be applied in the asymmetric hydroboration of allylamine to afford 1,3-amino alcohol, which is a key intermediate for the synthesis of fluoxetine and atomoxetine. Furthermore, control experiments, isotopic labeling experiments, and qualitative and quantitative kinetic studies were also conducted to figure out the primary mechanism.
If you are interested in 937-30-4, you can contact me at any time and look forward to more communication. Recommanded Product: 4-Ethylacetophenone.
Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
,Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis