Chemistry is traditionally divided into organic and inorganic chemistry. Quality Control of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 126456-43-7
Tandem and two-directional asymmetric catalysis of the Mukaiyama aldol reaction
Upon addition of an excess amount of an aldehyde 3, the Mukaiyama aldol reaction of a silyl enol ether 2 proceeds in tandem and two-directional fashion by the asymmetric catalysis of a binaphthol-derived chiral titanium complex (BINOL-Ti: 1) to give the silyl enol ether 4 in 77% isolated yield in more than 99% de and 99% de. The present asymmetric catalytic Mukaiyamn aldol reaction is characterized by amplification phenomena of the product chirality on going from the one-directional aldo intermediate 6 (98.5% ee, R) to the two-directional product 4 (99.6% ee, R,R). Further transformation of the pseudo C2 symmetric product 4 (> 99% ee, > 99% de) in its’ protected form as the silyl enol ether is established leading to a potentially potent analogue of HIVP inhibitor 9a.
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Reference£º
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis