Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 3896-11-5, Name is 2-(tert-Butyl)-6-(5-chloro-2H-benzo[d][1,2,3]triazol-2-yl)-4-methylphenol. In a document, author is Senatore, Raffaele, introducing its new discovery. COA of Formula: C17H18ClN3O.
Weinreb Amides as Privileged Acylating Agents for Accessing alpha-Substituted Ketones
The acylation of alpha-substituted carbanion-type reagents (MCR (1) R (2) X; X = halogen, OR, SR, NR (3) R (4) , SeR, etc.) with Weinreb amides constitutes a highly versatile and flexible approach for accessing alpha-functionalized ketones. In this short review we will present a series of transformations-from our own and the work of others-documenting the general applicability of the methodology. Chemoselectivity is uniformly manifested including for critical substrates featuring additional electrophilic functionalities or sterically demanding elements. Importantly, the stereochemical information contained in the Weinreb amides can be fully transferred to the targeted ketones without affecting the optical purity. The protocol is also applicable to chiral carbanions generated through sparteine-mediated asymmetric deprotonation: the careful design of the experimental procedure allows recycling of the sparteine and the Weinreb amine’ ( N , O -dimethylhydroxylamine), thus improving the sustainability perspective of the processes. 1 Introduction 1.1 The Problem of the Synthesis of alpha-Substituted Ketones 1.2 Weinreb Amides: General Features and Preparation 2 Synthesis of alpha-Substituted Ketones 2.1 alpha-Haloketones 2.2 Synthesis of alpha-Cyanoketones 2.3 Synthesis of alpha-Oxyketones 2.4 Synthesis of beta-Oxo Thioethers (alpha-Thioketones) 2.5 Synthesis of Chiral alpha-Oxy and alpha-Nitrogen Ketones via the Sparteine-Mediated Generation of Optically Active Organolithiums 2.6 Synthesis of alpha-Selenomethyl Ketones 2.7 Reactivity of alpha-Phosphorus Carbanions with Weinreb Amides 2.8 Modification of the Weinreb Amide Core: The CLAmP Reagent 3 Competing Attack of Nucleophiles at More Reactive Electrophilic Sites than Weinreb Amides 4 Conclusions
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 3896-11-5 help many people in the next few years. COA of Formula: C17H18ClN3O.
Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
,Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis