Name: 2-Aminoquinazolin-4(3H)-one. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Dicopper complexes catalyzed coupling/cyclization of 2-bromobenzoic acids with amidines leading to quinazolinones. Author is Hung, Ming-Uei; Liao, Bei-Sih; Liu, Yi-Hong; Peng, Shie-Ming; Liu, Shiuh-Tzung.
Dicopper(I) complexes {[Cu2(bpnp)(MeCN)4](PF6)2} (I), {[Cu2(bpnp)(MeCN)4](BAr4F)2} {BAr4F = B[C6H3-3,5-(CF3)2]4}, and [Cu2(bpnp)Cl2] (II) were prepared from the complexation of [Cu(MeCN)4](PF6) with 2,7-bis(2-pyridyl)-1,8-naphthyridine (bpnp) followed by anion metathesis and treatment of chloride sequentially. X-ray structural anal. of II (data deposited with the CCDC) indicates the mol. to have a 2-fold axis passing through the Cu2Cl2 core, which has the shape of a butterfly, and that the Cu atom is tetrahedrally coordinated with in a Cl2N2 donor set. In preliminary experiments, I was found to be an effective catalyst in the coupling/cyclization of 2-bromobenzoic acids with amidines, providing the corresponding quinazolinones in good yields. Copyright © 2014 John Wiley & Sons, Ltd.
There is still a lot of research devoted to this compound(SMILES：O=C1NC(N)=NC2=C1C=CC=C2)Name: 2-Aminoquinazolin-4(3H)-one, and with the development of science, more effects of this compound(20198-19-0) can be discovered.
Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis