The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1,5-Dibromopentane(SMILESS: BrCCCCCBr,cas:111-24-0) is researched.Reference of 2-Aminoquinazolin-4(3H)-one. The article 《General sulfone construction via sulfur dioxide surrogate control》 in relation to this compound, is published in Green Chemistry. Let’s take a look at the latest research on this compound (cas:111-24-0).
A highly efficient one-step synthesis of alkyl-alkyl and aryl-alkyl sulfones with a facile combination of halides, sulfur dioxide surrogates and phosphate esters is described. When thiourea dioxide was employed as a reductive sulfur dioxide surrogate, alkyl-alkyl sulfones were obtained under transition metal free conditions. Aryl-alkyl sulfones were obtained with an extremely low catalytic loading (0.2 mol%) via altering the mask of sulfur dioxide surrogates to sodium dithionite. A phosphate ester was employed as a stable and readily available alkyl source. Notably, this protocol has been applied to the late-stage modification of natural products and bioactive mols. Thus, e.g., treatment of (2-bromoethyl)benzene with thiourea dioxide and P(:O)(OMe)3 in presence of Cs2CO3, KI and TBAI afforded [2-(methylsulfonyl)ethyl]benzene (71%).
Different reactions of this compound(1,5-Dibromopentane)HPLC of Formula: 111-24-0 require different conditions, so the reaction conditions are very important.
Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis