Category: 1663-45-2

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1,2-Bis(diphenylphosphino)ethane, is researched, Molecular C26H24P2, CAS is 1663-45-2, about Homoleptic versus heteroleptic trinuclear systems with mixed L-cysteinate and D-penicillaminate regulated by a diphosphine linker.HPLC of Formula: 1663-45-2.

Controlled generation of homoleptic vs. heteroleptic AuI2M (M = NiII, ZnII) trinuclear complexes, which is achieved by a slight change in the diphosphine P^P linker of digold(I) metalloligands, [Au2(P^P)(D-pen)2]2- (L1P^P; D-pen = D-penicillaminate) and [Au2(P^P)(L-cys)2]2- (L2P^P; L-cys = L-cysteinate), is reported. The reactions of a 1 : 1 mixture of L1dppm and L2dppm (dppm = bis(diphenylphosphino)methane) with M = NiII, ZnII gave the homoleptic AuI2M complexes, [M(L1dppm)] and [M(L2dppm)], which co-crystallized to form [M(L1dppm)]·[M(L2dppm)] (1M). Similar reactions using L1dppe and L2dppe (dppe = bis(diphenylphosphino)ethane), instead of L1dppm and L2dppm, led to the selective production and crystallization of the heteroleptic AuI2M complex, [M(L3dppe)] (2M; L3dppe = [Au2(dppe)(L-cys)(D-pen)]2-), accompanied by the scrambling of L1dppe and L2dppe. The homoleptic 1M and the heteroleptic 2M showed different absorption (green vs. blue) and emission (yellow vs. orange) colors for M = NiII and ZnII, resp.

The article 《Homoleptic versus heteroleptic trinuclear systems with mixed L-cysteinate and D-penicillaminate regulated by a diphosphine linker》 also mentions many details about this compound(1663-45-2)HPLC of Formula: 1663-45-2, you can pay attention to it or contacet with the author([email protected]; [email protected]; [email protected]) to get more information.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Safety of 1,2-Bis(diphenylphosphino)ethane. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1,2-Bis(diphenylphosphino)ethane, is researched, Molecular C26H24P2, CAS is 1663-45-2, about Palladium(II)-salicylanilide complexes as antibacterial agents: Synthesis, spectroscopic, structural characterization, DFT calculations, biological and in silico studies. Author is Al-Janabi, Ahmed S. M.; Yousef, Tarek A.; Al-Doori, Mohammed E. A.; Bedier, R. A.; Ahmed, Basil M..

Palladium(II)-Salicylanilide complexes of the type [Pd(κ2-Saln)2] (1), [Pd(κ2-Saln)2(diphos)] (2-6) (diphos = dppe, dppp, dppb, dppf, and dppmS2) and [Pd(κ2-Saln)2(μ-dppm)] (7) were synthesized and characterized. The salicylanidate ligand (Saln-) was bonded as bidentate chelating through the O atoms of hydroxyl and carbonyl groups in complex (1), whereas coordinated as monodentate through the O atom of hydroxyl group in complexes (2-7), and the all diphosphine ligands except dppm bonded as bidentate chelating to afford a square planner geometry around the Pd(II) ion. The dppm ligand was coordinated as bidentate bridging to afford binuclear complex. The prepared complexes displayed respectable activity against the pathogen bacteria species. 5 Showed the highest inhibition value against all types of bacteria, compared to the other complexes and the free ligand. However, the complex [Pd(Saln)2], showed the lowest inhibition against all types of bacteria. And the inhibition sequence of complexes is as following: (5) > (4) > (2) > (3) > HSaln > (1). Calculations of d. function theory (DFT) were performed at the B3LYP/6-311G(d,p) level involved in the Gaussian 09 program to inspect the optimized structures of the chelating agent and its complexes. Docking study of the ligand was performed against the proteins of bacterial strains Pseudomonas aeruginosa (ID: 3P3E), Escherichia coli (ID: 1C14), Staphylococcus aureus (ID: 3BL6), and Salmonella typhimurium (ID: 3V7F) by Auto-Dock tools to portend the best binding mode.

The article 《Palladium(II)-salicylanilide complexes as antibacterial agents: Synthesis, spectroscopic, structural characterization, DFT calculations, biological and in silico studies》 also mentions many details about this compound(1663-45-2)Safety of 1,2-Bis(diphenylphosphino)ethane, you can pay attention to it, because details determine success or failure

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Hansen, Line Sofie; Jakobsen, Vibe Boel; McKee, Vickie; McKenzie, Christine J. published an article about the compound: 1,2-Bis(diphenylphosphino)ethane( cas:1663-45-2,SMILESS:P(CCP(C1=CC=CC=C1)C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4 ).Name: 1,2-Bis(diphenylphosphino)ethane. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1663-45-2) through the article.

The polymeric complex trans-[Ni(acac)2(μ2-dppe)]n·2MeCN {1a, dppe = 1,2-ethylenebis(diphenylphosphine)} is sometimes transiently deposited from the reaction of [Ni(acac)2] with dppe in MeCN prior to its facile onwards air oxidation to final crystallization of a doubly-oxygenated relative, cis-[Ni(acac)2(μ2-dppeO2)]n {2, dppeO2 = 1,2-ethylenebis(diphenylphosphineoxide)}. A similar unsolvated phase of the initial polymer, trans-[Ni(acac)2(μ2-dppe)]n (1b), can be isolated from toluene. The oxidation of dppe by O2 is catalytic and dppeO2 was isolated in close to stoichiometric yields from solutions containing 5% Ni(acac)2 relative to dppe. The reaction rate slows after a few turnovers due to inhibition by the product. The relative yields of dppeO2 are higher than those from catalytic air oxidation of methyldiphenylphosphine and triphenylphosphine and we speculate that a pathway for this reaction involves a dimetallic cooperativity enabled specifically by dppe.

The article 《Acetylacetonate and Acetate Complexes of Nickel(II) Catalyse the Air Oxidation of Phosphines》 also mentions many details about this compound(1663-45-2)Name: 1,2-Bis(diphenylphosphino)ethane, you can pay attention to it, because details determine success or failure

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1,2-Bis(diphenylphosphino)ethane, is researched, Molecular C26H24P2, CAS is 1663-45-2, about Regioselective ortho-Palladation of [2.2]Paracyclophane Scaffolds: Accessing Planar and Central Chiral N,C-Palladacycles, the main research direction is crystal structure mol chiral palladacycle palladium paracyclophane complex preparation; regioselective ortho palladation paracyclophane chiral metalation.COA of Formula: C26H24P2.

In this report, we describe a series of cyclophanyl-derived mono- and binuclear N,C-palladacycles by regioselective ortho-palladation of amine-functionalized [2.2]paracyclophanes. Employing Pd(OAc)2 followed by LiCl and with the subsequent modular treatment of Ph3P, Cy3P, and (Ph2PCH2)2, this strategy allows to prepare stable cyclophanyl-derived planar and central chiral N,C-palladacycles in a highly selective manner. The regioselective ortho-palladation mono- and bimetallic product formation was analyzed by detailed spectroscopic techniques, mass spectrometry and unambiguously confirmed by single-crystal X-ray anal.

Different reactions of this compound(1,2-Bis(diphenylphosphino)ethane)COA of Formula: C26H24P2 require different conditions, so the reaction conditions are very important.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

COA of Formula: C26H24P2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1,2-Bis(diphenylphosphino)ethane, is researched, Molecular C26H24P2, CAS is 1663-45-2, about Understanding the acrylates formation from CO2 and ethylene over Ni- and Pd-based catalysts: A DFT study on the effects of solvents, methyl halides, and ligands. Author is Zhu, Youcai; Guo, Xing; Ding, Xinxin; Sun, Li; Zhang, Mingguo; Liu, Zhen.

In this work, two methylation reaction pathways were investigated to explore the role of solvent and I- on the formation of Me acrylate from coupling of CO2 and ethylene catalyzed by nickel and palladium catalysts in the presence of MeI. The stabilization of non-productive intermediates is inhibited in the gas phase as well as in low-polar solvents, which explains the requirement of high excess of MeI to obtain high yields of Me acrylate. The energy barrier for M-O bond cleavage as well as the stability of the overall reaction intermediates is consistent with the corresponding halogen electron-donating ability. The different catalytic behaviors of various bidentate ligands on Ni- and Pd-based catalysts were systematically investigated, mainly including dmpe(1,2-bis(dimethylphosphino)ethane), tmeda(tetramethylethylenediamine), dppe(1,2-bis(diphenylphosphino)ethane), dcpe(1,2-bis(dicyclohexylphosphino)ethane) and dtbpe(1,2-bis(di-tert-butylphosphino)ethane). The energy barrier of M-O bond cleavage increases with the enhancement of ligand steric hindrance in the O1 (ester sp3 O atom) attack mechanism, while the corresponding O2 (carboxylic sp2 O atom) attack mechanism shows an opposite trend. The energy barrier of β-H elimination in both catalytic systems is strongly related to the electron-donating ability of the diphosphine ligand substituents. The dcpp(1,3-bis(dicyclohexylphosphino)propane) ligand shows relatively good performance for β-H elimination among all the investigated ligands in Pd-mediated system. In general, diphosphine ligands are superior to diamine ligands in Pd-mediated system in terms of efficiency.

Different reactions of this compound(1,2-Bis(diphenylphosphino)ethane)COA of Formula: C26H24P2 require different conditions, so the reaction conditions are very important.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1,2-Bis(diphenylphosphino)ethane(SMILESS: P(CCP(C1=CC=CC=C1)C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4,cas:1663-45-2) is researched.Product Details of 14389-12-9. The article 《Synthesis and Structural Characterization of Palladium(II) Mixed-Ligand Complexes of N-(Benzothiazol-2-yl)benzamide and 1,2-Bis(diphenylphosphino)ethane》 in relation to this compound, is published in Inorganic Chemistry. Let’s take a look at the latest research on this compound (cas:1663-45-2).

Three novel palladium(II) mixed-ligand complexes of N-(benzothiazol-2-yl)benzamide (HL) and 1,2-bis(diphenylphosphino)ethane (dppe), [Pd(HL)(dppe)]Cl2 (1), [Pd(L)(dppe)]Cl (2), and [Pd(L)2(dppe)] (3), were synthesized and fully characterized using Fourier transform IR, 1H, 13C, and 31P NMR, and molar conductivity measurements. Complex 3 was characterized by single-crystal X-ray diffraction. The ligand HL showed three different coordination modes: a neutral bidentate chelate bound through the endocyclic nitrogen and exocyclic oxygen atoms in 1, a neg. charged L bound as a bidentate chelate through the endocyclic nitrogen and neg. charged exocyclic oxygen atoms in 2, and a monodentate bound through the neg. charged endocyclic nitrogen atom in 3.

The article 《Synthesis and Structural Characterization of Palladium(II) Mixed-Ligand Complexes of N-(Benzothiazol-2-yl)benzamide and 1,2-Bis(diphenylphosphino)ethane》 also mentions many details about this compound(1663-45-2)HPLC of Formula: 1663-45-2, you can pay attention to it, because details determine success or failure

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Electric Literature of C26H24P2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1,2-Bis(diphenylphosphino)ethane, is researched, Molecular C26H24P2, CAS is 1663-45-2, about Fully Solvated, Monomeric ReII Complexes: Insights into the Chemistry of [Re(NCCH3)6]2+. Author is Bolliger, Robin; Meola, Giuseppe; Braband, Henrik; Blacque, Olivier; Siebenmann, Lukas; Nadeem, Qaisar; Alberto, Roger.

The oxidation of [Re(η6-C10H8)2]+ with AgI in acetonitrile yields [Re(NCCH3)6]2+. This fully solvated ReII compound was characterized by spectroscopic methods and x-ray structure analyses. Authors show that [Re(NCCH3)6]2+ acts as a precursor complex for a variety of substitution reactions. Treatment with monodentate triphenylphosphine (PPh3) and bidentate 1,2-bis(diphenylphosphino)ethane (dppe) yields the complexes [trans-Re(PPh3)2(NCCH3)4]2+ and [trans-Re(dppe)2(NCCH3)2]+, resp. [trans-Re(dppe)2(NCCH3)2]+ is oxidized under mild conditions by AgI to its ReII analog [trans-Re(dppe)2(NCCH3)2]2+. Reactions of [Re(NCCH3)6]2+ with a halide mixture consisting of NaX and AgX (X = Cl, I) result in the formation of the corresponding ReIII complexes [trans-ReX2(NCCH3)4]+. [Trans-ReBr2(NCCH3)4]+ can be obtained directly from [Re(η6-C10H8)2]+ by oxidation with FeBr3 in acetonitrile. The title compound is thus a convenient starting material for ReII and ReIII complexes by simple solvent exchange, which are otherwise difficult to access.

After consulting a lot of data, we found that this compound(1663-45-2)Electric Literature of C26H24P2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, ACS Catalysis called Synthesis of Phosphinines from CoII-Catalyzed [2+2+2] Cycloaddition Reactions, Author is Glaesel, Tim; Jiao, Haijun; Hapke, Marko, which mentions a compound: 1663-45-2, SMILESS is P(CCP(C1=CC=CC=C1)C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4, Molecular C26H24P2, Name: 1,2-Bis(diphenylphosphino)ethane.

The CoII-catalyzed [2+2+2] cycloaddition of functionalized diynes and phosphaalkynes resulting in the formation of an array of structurally interesting phosphinines is reported. A combination of 1,2-bis(diphenylphosphino)benzene (dppbenz) and CoI2 turned out to be the most suitable and active catalyst system under microwave reaction conditions. Chemoselective cyclizations of phosphaalkynes in the presence of nitriles have been observed, and a number of carbonyl functionalities are tolerated as well. The reaction can successfully be conducted with a 1:1 ratio of phosphaalkyne/diyne substrate. Model reactions with benzonitrile and diyne demonstrated that CoII catalysts in the presence of bisphosphines prefer carbocyclization, while reduction to lower oxidation states promotes heterocyclization to the corresponding pyridine. A reaction mechanism comprising a CoII oxidation state for the cyclotrimerization process is proposed and rationalized based on control experiments and theor. calculations

After consulting a lot of data, we found that this compound(1663-45-2)Name: 1,2-Bis(diphenylphosphino)ethane can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Reference of 1,2-Bis(diphenylphosphino)ethane. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1,2-Bis(diphenylphosphino)ethane, is researched, Molecular C26H24P2, CAS is 1663-45-2, about Ranking Ligands by Their Ability to Ease (C6F5)2Ni(II)L → Ni0L + (C6F5)2 Coupling versus Hydrolysis: Outstanding Activity of PEWO Ligands. Author is Ponce-de-Leon, Jaime; Gioria, Estefania; Martinez-Ilarduya, Jesus M.; Espinet, Pablo.

The NiII literature complex cis-[Ni(C6F5)2(THF)2] is a synthon of cis-Ni(C6F5)2 that allows the authors to establish a protocol to measure and compare the ligand effect on the Ni(II) → Ni(0) reductive elimination step (coupling), often critical in catalytic processes. Several ligands of different types were submitted to this Ni-meter comparison: bipyridines, chelating diphosphines, monodentate phosphines, PR2(biaryl) phosphines, and PEWO ligands (phosphines with one potentially chelate electron-withdrawing olefin). Extremely different C6F5-C6F5 coupling rates, ranging from totally inactive (producing stable complexes at room temperature) to those inducing almost instantaneous coupling at 25°, were found for the different ligands tested. The PR2(biaryl) ligands, very efficient for coupling in Pd, are slow and inefficient in Ni, and the reason for this difference was examined In contrast, PEWO type ligands are amazingly efficient and provide the lowest coupling barriers ever observed for NiII complexes; they yield up to 96% C6F5-C6F5 coupling in 5 min at 25° (the rest is C6F5H) and 100% coupling with no hydrolysis in 8 h at -22 to -53°. The ability of ligands to facilitate a difficult C-C coupling and protect from hydrolysis in Ni(II) is very different from their performance in Pd(II). Most remarkably, PR2(biaryl) ligands with very good performance in Pd(II) are not efficient in Ni(II), whereas PEWO ligands are amazingly efficient and induce C6F5-C6F5 coupling even at -50°.

After consulting a lot of data, we found that this compound(1663-45-2)Reference of 1,2-Bis(diphenylphosphino)ethane can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Product Details of 1663-45-2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1,2-Bis(diphenylphosphino)ethane, is researched, Molecular C26H24P2, CAS is 1663-45-2, about Protective cellular immune response induction for cutaneous leishmaniasis by a new immunochemotherapy schedule. Author is Da Silva, Danielle A. M.; Santana, Fabiana R.; Katz, Simone; Garcia, Daniel M.; Teixeira, Daniela; Longo-Maugeri, Ieda M.; Barbieri, Clara L..

The palladacycle complex DPPE 1.2 was previously shown to inhibit Leishmania (Leishmania) amazonensis infection in vitro and in vivo. The present study aimed to evaluate the effect of DPPE 1.2 associated with a recombinant cysteine proteinase, rLdccys1, and the adjuvant Propionibacterium acnes on L. (L.) amazonensis infection in two mouse strains, BALB/c, and C57BL/6. Treatment with this association potentiated the leishmanicidal effect of DPPE 1.2 resulting in a reduction of parasite load in both strains of mice which was higher compared to that found in groups treated with either DPPE 1.2 alone or associated with P. acnes or rLdccys1. The reduction of parasite load in both mice strains was followed by immunomodulation mediated by an increase of memory CD4+ and CD8+ T lymphocytes, IFN-γ levels and reduction of active TGF-β in treated animals. No infection relapse was observed 1 mo after the end of treatment in mice which received DPPE 1.2 associated with rLdccys1 or rLdccys1 plus P. acnes in comparison to that exhibited by animals treated with DPPE 1.2 alone. Evaluation of serum levels of AST, ALT, urea, and creatinine showed no alterations among treated groups, indicating that this treatment schedule did not induce hepato or nephrotoxicity. These data indicate the potential use of this association as a therapeutic alternative for cutaneous leishmaniasis caused by L. (L) amazonensis.

Although many compounds look similar to this compound(1663-45-2)Product Details of 1663-45-2, numerous studies have shown that this compound(SMILES:P(CCP(C1=CC=CC=C1)C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis