Category: 20198-19-0

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Reactivity of anode-generated dialkyl trimethylsilyl phosphite cation radicals, published in 1988-01-31, which mentions a compound: 20198-19-0, Name is 2-Aminoquinazolin-4(3H)-one, Molecular C8H7N3O, Application In Synthesis of 2-Aminoquinazolin-4(3H)-one.

The electrochem. oxidation of diethyltrimethylsilylphosphite and dibutyltrimethylsilylphosphite was studied in the presence of benzene and alkylbenzene using the method of competitive reactions. The assumption that the highly active electrophilic particles, cation radicals of dialkyltrimethylsilylphosphites, are playing role in the electrochem. process was confirmed. The selectivity of the substitution reaction of (RO)2POSiMe3 with alkylbenzene was studied as a function of the R position. A good correlation was observed between electrophilic constants and electrochem. data.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Biological evaluation and molecular docking of substituted quinazolinones as antimicrobial agents.Name: 2-Aminoquinazolin-4(3H)-one.

Antibiotic resistance in the community is a growing public health concern due to the continued emergence of multi drug resistant bacterial strains. In view of this fact, the design and synthesis of newer antibacterials are of immense significance and continue to attract the attention of numerous medicinal chemists. The aim of this study was to investigate the effect of four quinazolinone derivatives (Ia, II, III and IV) on the microbial cell morphol. and genes coded for rRNA subunits. It was extended also to elucidate the effect of the most active derivatives on DNA-gyrase enzyme by performing a mol. docking study. Quinazolinone derivatives revealed good anti-bacterial activities, especially against Gram-pos. strains through their interaction with cell wall and DNA structures. The tested compounds showed moderate activity against fungal strains through affecting the internal structures of fungal cell in addition to studied genes. Compound II was found to be the most active gyrase inhibitor as illustrated by the docking study. Conclusion: The type and position of chem. substituents confer the antimicrobial activity of quinazolinone.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Related Products of 20198-19-0. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Synthesis of 2-amino-4-quinazolones and spectral study of their tautomeric equilibrium state. Author is Shakhidoyatov, Kh. M.; Yun, L. M.; Samiev, R. A..

The identity of UV spectra of the parent and methylated aminoquinazolones I (R,R1 = H,H; Me,H; H,Me; Me,Me) was evidence for a single amino-keto tautomeric form with double bond C4:O and N1:C2. Comparison of UV spectra in neutral and basic media established that deprotonation occurs at N3 only in the parent (R,R1 = H,H) compound, consistent with the observed methylation at N3; i.e., no deprotonation of the amino group is observed under these conditions.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Aminoquinazolin-4(3H)-one( cas:20198-19-0 ) is researched.Synthetic Route of C8H7N3O.Masharipov, S.; Nazhimov, K. O.; Kasymova, S. S.; Askarov, M. A. published the article 《4-Quinazolone derivatives as stabilizers for PVC》 about this compound( cas:20198-19-0 ) in Plasticheskie Massy. Keywords: quinazolone derivative heat stabilizer PVC. Let’s learn more about this compound (cas:20198-19-0).

Derivatives of 4-quinazolone increased the thermal stability of PVC by 2-16 fold. The inhibiting action of 4-quinazolone derivatives during PVC degradation is due to to the binding of gaseous HCl and replacement of labile Cl atoms by the quinazolone groups, and their stabilization activity depends on the type of groups replacing H in 4-quinazolone. The thermal stability of PVC linoleum containing 2-amino-4-quinazolone-Co acetate complex was 2.5-3 fold higher than that of PVC containing com. Ca stearate, without changes in physicomech. properties and with improvement of properties in some cases.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Application of 20198-19-0. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Fluorescence characteristics of 3-aminoisocarbostyril derivatives (3). Fluorescence characteristics of isocarbostyrils and related compounds. Author is Takadate, Akira; Yoshimura, Naonori; Goya, Shujiro; Matsumoto, Hitoshi.

The fluorescence spectra of I (R = H, H2N, PhNH; Z = NH, O) and II were studied with respect to their structures. The maximum depended on such partial structures as lactam, lactone, or guanidino moieties. All compounds except II (R = PhNH2) (III) exhibited high fluorescence in EtOH. III and 2-anilino-4-methoxyquinazoline showed significant increased fluorescence in less polar solvents such as C6H6 and cyclohexane.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Novel Inhibitors of Trihydroxynaphthalene Reductase with Antifungal Activity Identified by Ligand-Based and Structure-Based Virtual Screening.Recommanded Product: 20198-19-0.

Curvularia lunata is a dark pigmented fungus that is the causative agent of several diseases in plants and in both immunodeficient and immunocompetent patients. 1,8-Dihydroxynaphthalene-melanin is found in the cell wall of C. lunata and is believed to be the important virulence factor of dematiaceous fungi. Trihydroxynaphthalene reductase is an enzyme of the 1,8-dihydroxynaphthalene-melanin biosynthetic pathway, and it thus represents an emerging target for the development of novel fungicides and antimycotics. In the present study, the authors describe novel inhibitors of trihydroxynaphthalene reductase from C. lunata. These inhibitors were identified by ligand-based three-dimensional similarity searching and docking to a homol.-built model and by subsequent biochem. and antifungal evaluation. Discovery of competitive inhibitors with Ki values in low micromolar and even nanomolar concentration range proves the aplicability of homol.-built model of 3HNR for hit finding by virtual screening methods.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 20198-19-0, is researched, SMILESS is O=C1NC(N)=NC2=C1C=CC=C2, Molecular C8H7N3OJournal, Chemical Physics called Electronic spectra of some pterins and deazapterins, Author is Wormell, Paul; Gready, Jill E., the main research direction is electron spectra pterin deazapterin; tautomerism electron spectra pterin deazapterin; protonation electron spectra pterin deazapterin.COA of Formula: C8H7N3O.

The electronic absorption spectra of some derivatives of pterin and N5-deazapterin are analyzed using the CNDO/S-CI method, including allowance for solvent shifts. These calculations give good agreement with the spectra, which may be assigned to a group of π*←π transitions. There are some differences between calculated values for gas-phase and solution models but their general level of conformity with experiment is similar. Band shifts caused by Me substitution, protonation and replacement of ring nitrogens are investigated, and a number of structural and spectroscopic problems are addressed. The spectral predictions agree well with exptl. assignments for tautomeric forms and protonation sites for known compounds, and predictions are made for the spectra of N8-deazapterin and N5,N8-dideazapterin which have not been reported.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 20198-19-0, is researched, SMILESS is O=C1NC(N)=NC2=C1C=CC=C2, Molecular C8H7N3OJournal, Khimiya Geterotsiklicheskikh Soedinenii called Acylation of 2-amino-4-quinazolones unsaturated acyl chlorides, Author is Yun, L. M.; Nazhimov, K. O.; Masharipov, S.; Samiev, R. A.; Makhmudov, S. A.; Kasymova, S. S.; Vergizov, S. N.; V’yunov, K. A.; Shakhidoyatov, Kh. M., the main research direction is acylation aminoquinazolone unsaturated chloride; pyrimidoquinazolinedione; quinazolone amino acylation unsaturated chloride.Safety of 2-Aminoquinazolin-4(3H)-one.

Condensation of quinazolone I by R1CH:CRCOCl (R = Me, R1 = H; R = H, R1 = Me, Ph) in DMF containing Et3N gave 36-70% acylated derivatives II which (R = Me, R1 = H) underwent intramol. cycloaddition at 250-260° to give 43% pyrimidoquinazolinedione III. Addnl. acylations of the 2-Me derivative of I gave 15-49% quinazolones IV.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Efficient Cu-catalyzed synthesis of 2-amino-4(3H)-quinazolinone and 2-aminoquinazoline derivatives, the main research direction is halo aryl carbonyl guanidine cyclization copper catalyst; quinazolinamine preparation; quinazolinone amino preparation.Related Products of 20198-19-0.

A versatile and efficient method for the Cu-catalyzed synthesis of both 2-amino-4(3H)-quinazolinones and -quinazolines was developed. The protocol uses readily available substituted 2-halobenzoates, 2-BrC6H4CHO, 2-bromophenyl ketones, and guanidines as starting materials, inexpensive CuI as the catalyst, and has important application values for the construction of N-heterocycles.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Aminoquinazolin-4(3H)-one( cas:20198-19-0 ) is researched.Formula: C8H7N3O.Rifkin, Jared L.; Wali, Abdul W. published the article 《Effects of pteridines on the filopodia of Dictyostelium discoideum vegetative amebae》 about this compound( cas:20198-19-0 ) in Cell Motility and the Cytoskeleton. Keywords: Dictyostelium filopodia pteridine chemotaxis. Let’s learn more about this compound (cas:20198-19-0).

Living vegetative amebas of NC-4H D. discoideum were studied to determine if a variety of pteridines had any effect on the filopodia. Production, elongation, and branching of these filopodia were stimulated by pteridines that are chemoattractants for cells of this strain. This stimulation occurred at chemotactically effective concentrations and was observed before motility was evident. A relationship between filopodia and chemoattractant signal processing is discussed.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis