Category: 20198-19-0

Name: 2-Aminoquinazolin-4(3H)-one. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Derivatives of 4-quinazolone as heat stabilizers for poly(vinyl chloride) and vinyl chloride-vinyl acetate copolymers. Author is Kasymova, S. S.; Masharipov, S. M.; Tadzhieva, Kh. S.; Makhmudov, S. A.; Yun, L. M.; Shakhidoyatov, Kh. M..

The stabilizing effect of 4-quinazolone  [491-36-1], 2-amino-4-quinazolone (I) [20198-19-0], 2-amino-3-methyl-4-quinazolone (II) [91810-61-6] and 2-amino-3-methyl-6-nitro-4-quinazolone  [91810-62-7] on PVC  [9002-86-2] and vinyl acetate-vinyl chloride copolymer  [9003-22-9] was studied. The highest heat resistance of the polymers was obtained by stabilization with I, and to a lower degree, with II, whereas the other quinazolone derivatives had no stabilizing effect on the polymers. The effect of mixtures of II with com. stabilizers Ca stearate or Ba-Cd stearate on the heat resistance of PVC depended nonmonotonically on the component ratio, whereas the effect of mixtures of I and other quinazolone derivatives with com. stabilizers increased with increasing content of the former.

If you want to learn more about this compound(2-Aminoquinazolin-4(3H)-one)Name: 2-Aminoquinazolin-4(3H)-one, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(20198-19-0).

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

COA of Formula: C8H7N3O. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Heterocyclic photorearrangements. Some investigations of the photochemical behavior of 3-acylamino-1,2,4-oxadiazoles. Synthesis of the quinazolin-4-one system. Author is Buscemi, Silvestre; Vivona, Nicolo.

Some mechanistic investigations on the photochem. behavior of 1,2,4-oxadiazoles are reported. Irradiation of 3-benzoylamino-5-methyl-1,2,4-oxadiazole at λ = 254 nm in methanol involves excitation of the benzoylamino group chromophore to a triplet state species and induces a 6π electrocyclic closure to a tricyclic intermediate. On the other hand, irradiation of 3-acetylamino-5-phenyl-1,2,4-oxadiazole at λ =254 nm involves excitation of a 5-phenyl-substituted oxadiazole chromophore which leads to the photolysis of the ring O-N bond in a singlet state species. Furthermore, irradiation of some selected 5-Ph substituted oxadiazoles in the presence of a triplet sensitizer produces an excited triplet state species which collapses in a ring closure reaction involving the C5-Ph moiety.

Here is a brief introduction to this compound(20198-19-0)COA of Formula: C8H7N3O, if you want to know about other compounds related to this compound(20198-19-0), you can read my other articles.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Optimizing Fragment and Scaffold Docking by Use of Molecular Interaction Fingerprints, the main research direction is protein ligand scaffold docking mol interaction fingerprint.Product Details of 20198-19-0.

Protein-ligand interaction fingerprints have been used to postprocess docking poses of three ligand data sets: a set of 40 low-mol.-weight compounds from the Protein Data Bank, a collection of 40 scaffolds from pharmaceutically relevant protein ligands, and a database of 19 scaffolds extracted from true cdk2 inhibitors seeded in 2230 scaffold decoys. Four popular docking tools (FlexX, Glide, Gold, and Surflex) were used to generate poses for ligands of the three data sets. In all cases, scoring by the similarity of interaction fingerprints to a given reference was statistically superior to conventional scoring functions in posing low-mol.-weight fragments, predicting protein-bound scaffold coordinates according to the known binding mode of related ligands, and screening a scaffold library to enrich a hit list in true cdk2-targeted scaffolds.

Here is a brief introduction to this compound(20198-19-0)Product Details of 20198-19-0, if you want to know about other compounds related to this compound(20198-19-0), you can read my other articles.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Chemistry of Heterocyclic Compounds (New York, NY, United States)(Translation of Khimiya Geterotsiklicheskikh Soedinenii) called Reaction of some heterocyclic formamidines with trimethylsilylethynyllithium, Author is Ajana, W.; Helliwell, M.; Collison, D.; Garner, C. D.; Joule, J. A., which mentions a compound: 20198-19-0, SMILESS is O=C1NC(N)=NC2=C1C=CC=C2, Molecular C8H7N3O, COA of Formula: C8H7N3O.

The reaction of a 2-[(dimethylamino)methyleneamino]pteridine, two 2-[(dimethylamino)methyleneamino]pyrimidines, and a 2-[(dimethylamino)methyleneamino]pyrido[2,3-d]pyrimidine with trimethylsilylethynylithium in the presence of benzyl chloroformate leads to the corresponding 2-[bis(trimethylsilylethynyl)methylamino]-substituted heterocycles. A series of such substrates was prepared and some of the factors which permit this transformation were delineated. For example, 2-[bis(trimethylsilylethynyl)methylamino]-5,6,7,8-tetrahydro-3-(2,2-dimethylpropanoyloxymethyl)quinazolin-4-one was produced, for which a crystal structure is presented.

There is still a lot of research devoted to this compound(SMILES：O=C1NC(N)=NC2=C1C=CC=C2)COA of Formula: C8H7N3O, and with the development of science, more effects of this compound(20198-19-0) can be discovered.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Gready, Jill E. published an article about the compound: 2-Aminoquinazolin-4(3H)-one( cas:20198-19-0,SMILESS:O=C1NC(N)=NC2=C1C=CC=C2 ).Recommanded Product: 20198-19-0. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:20198-19-0) through the article.

A purely structural definition of aromaticity based on the average ring bond length and π-bond order is proposed. The definition is illustrated for N-heterocycles by reference to theor. sto-3G and 3-21G geometries and charges for some pteridine derivatives The treatment focuses on the gross structural changes (i.e., ring size, overall degree of π-electron delocalization, and net ring charges), accompanying chem. changes, such as substitution, tautomerization, ring reduction, and deazination, as well as the structural interdependence of the two rings in a bicyclic ring system.

Here is a brief introduction to this compound(20198-19-0)Recommanded Product: 20198-19-0, if you want to know about other compounds related to this compound(20198-19-0), you can read my other articles.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

SDS of cas: 20198-19-0. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology. Author is Brennecke, Philip; Rasina, Dace; Aubi, Oscar; Herzog, Katja; Landskron, Johannes; Cautain, Bastien; Vicente, Francisca; Quintana, Jordi; Mestres, Jordi; Stechmann, Bahne; Ellinger, Bernhard; Brea, Jose; Kolanowski, Jacek L.; Pilarski, Radoslaw; Orzaez, Mar; Pineda-Lucena, Antonio; Laraia, Luca; Nami, Faranak; Zielenkiewicz, Piotr; Paruch, Kamil; Hansen, Espen; von Kries, Jens P.; Neuenschwander, Martin; Specker, Edgar; Bartunek, Petr; Simova, Sarka; Lesnikowski, Zbigniew; Krauss, Stefan; Lehtioe, Lari; Bilitewski, Ursula; Broenstrup, Mark; Tasken, Kjetil; Jirgensons, Aigars; Lickert, Heiko; Clausen, Mads H.; Andersen, Jeanette H.; Vicent, Maria J.; Genilloud, Olga; Martinez, Aurora; Nazare, Marc; Fecke, Wolfgang; Gribbon, Philip.

A review. Compound screening in biol. assays and subsequent optimization of hits is indispensable for the development of new mol. research tools and drug candidates. To facilitate such discoveries, the European Research Infrastructure EU-OPENSCREEN was founded recently with the support of its member countries and the European Commission. Its distributed character harnesses complementary knowledge, expertise, and instrumentation in the discipline of chem. biol. from 20 European partners, and its open working model ensures that academia and industry can readily access EU-OPENSCREEN’s compound collection, equipment, and generated data. To demonstrate the power of this collaborative approach, this perspective article highlights recent projects from EU-OPENSCREEN partner institutions. These studies yielded (1) 2-aminoquinazolin-4(3H)-ones as potential lead structures for new antimalarial drugs, (2) a novel lipodepsipeptide specifically inducing apoptosis in cells deficient for the pVHL tumor suppressor, (3) small-mol.-based ROCK inhibitors that induce definitive endoderm formation and can potentially be used for regenerative medicine, (4) potential pharmacol. chaperones for inborn Errors of metabolism and a familiar form of acute myeloid leukemia (AML), and (5) novel tankyrase inhibitors that entered a lead-to-candidate program. Collectively, these findings highlight the benefits of small-mol. screening, the plethora of assay designs, and the close connection between screening and medicinal chem. within EU-OPENSCREEN.

Here is a brief introduction to this compound(20198-19-0)SDS of cas: 20198-19-0, if you want to know about other compounds related to this compound(20198-19-0), you can read my other articles.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis