Category: chiral-nitrogen-ligands

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Basicity of Very Weak Bases in 1,2-Dichloroethane, published in 2016, which mentions a compound: 3411-48-1, Name is Tri(naphthalen-1-yl)phosphine, Molecular C30H21P, Category: chiral-nitrogen-ligands.

The basicity scale of very weak bases has been set up in 1,2-dichloroethane to give, for the first time, reliable quant. insights into the basic properties of weak bases in a low-polarity solvent. The scale contains 30 compounds, including anilines; phosphanes, and carbonyl bases, such as esters and amides, linked by 53 relative basicity measurements. The scale spans more than 12 pKip units, expanding to as low pKip values as possible with our current exptl. methodol.

Different reactions of this compound(Tri(naphthalen-1-yl)phosphine)Category: chiral-nitrogen-ligands require different conditions, so the reaction conditions are very important.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Tri(naphthalen-1-yl)phosphine, is researched, Molecular C30H21P, CAS is 3411-48-1, about The palladium-catalyzed addition of aryl- and heteroarylboronic acids to aldehydes, the main research direction is aryl substituted alc preparation; arylboronic acid aldehyde addition palladium phosphine; palladium phosphine addition reaction catalyst.SDS of cas: 3411-48-1.

Reaction of aryl- or heteroarylboronic acids with aldehydes, in the presence of PdCl2 and P(1-Nap)3, afforded carbinol derivatives in good to excellent yields. The efficiency of this reaction was demonstrated by the compatibility with nitro, cyano, acetamido, acetoxy, acetyl, carboxyl, trifluoromethyl, fluoro, and chloro groups and the possibility of involving aliphatic aldehyde or hindered substrates. Moreover, the rigorous exclusion of air/moisture is not required in these transformations.

Different reactions of this compound(Tri(naphthalen-1-yl)phosphine)SDS of cas: 3411-48-1 require different conditions, so the reaction conditions are very important.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1,2-Bis(diphenylphosphino)ethane, is researched, Molecular C26H24P2, CAS is 1663-45-2, about Regioselective ortho-Palladation of [2.2]Paracyclophane Scaffolds: Accessing Planar and Central Chiral N,C-Palladacycles, the main research direction is crystal structure mol chiral palladacycle palladium paracyclophane complex preparation; regioselective ortho palladation paracyclophane chiral metalation.COA of Formula: C26H24P2.

In this report, we describe a series of cyclophanyl-derived mono- and binuclear N,C-palladacycles by regioselective ortho-palladation of amine-functionalized [2.2]paracyclophanes. Employing Pd(OAc)2 followed by LiCl and with the subsequent modular treatment of Ph3P, Cy3P, and (Ph2PCH2)2, this strategy allows to prepare stable cyclophanyl-derived planar and central chiral N,C-palladacycles in a highly selective manner. The regioselective ortho-palladation mono- and bimetallic product formation was analyzed by detailed spectroscopic techniques, mass spectrometry and unambiguously confirmed by single-crystal X-ray anal.

Different reactions of this compound(1,2-Bis(diphenylphosphino)ethane)COA of Formula: C26H24P2 require different conditions, so the reaction conditions are very important.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 20198-19-0, is researched, SMILESS is O=C1NC(N)=NC2=C1C=CC=C2, Molecular C8H7N3OJournal, Article, Bioorganic & Medicinal Chemistry Letters called Discovery of selective 2,4-diaminoquinazoline toll-like receptor 7 (TLR 7) agonists, Author is Pieters, Serge; McGowan, David; Herschke, Florence; Pauwels, Frederik; Stoops, Bart; Last, Stefaan; Embrechts, Werner; Scholliers, Annick; Mostmans, Wendy; Van Dijck, Kris; Van Schoubroeck, Bertrand; Thone, Tine; De Pooter, Dorien; Fanning, Gregory; Rosauro, Mari Luz; Khamlichi, Mourad Daoubi; Houpis, Ioannis; Arnoult, Eric; Jonckers, Tim H. M.; Raboisson, Pierre, the main research direction is diaminoquinazoline preparation toll like receptor 7 agonistic activity; HBV; Quinazoline; TLR7.Reference of 2-Aminoquinazolin-4(3H)-one.

The discovery of a novel series of highly potent quinazoline TLR 7/8 agonists is described. The synthesis and structure-activity relationship is presented. Structural requirements and optimization of this series toward TLR 7 selectivity afforded the potent agonist I. Pharmacokinetic and pharmacodynamic studies highlighted I as an orally available endogenous interferon (IFN-α) inducer in mice.

Different reactions of this compound(2-Aminoquinazolin-4(3H)-one)Reference of 2-Aminoquinazolin-4(3H)-one require different conditions, so the reaction conditions are very important.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-(4-Pyridyl)-1H-tetrazole( cas:14389-12-9 ) is researched.Safety of 5-(4-Pyridyl)-1H-tetrazole.Pellizzeri, Steven; Delaney, Sean P.; Korter, Timothy M.; Zubieta, Jon published the article 《Using Terahertz Spectroscopy and Solid-State Density Functional Theory to Characterize a New Polymorph of 5-(4-pyridyl)tetrazole》 about this compound( cas:14389-12-9 ) in Journal of Physical Chemistry A. Keywords: terahertz spectroscopy solid DFT crystallog characterize polymorph pyridyltetrazole. Let’s learn more about this compound (cas:14389-12-9).

A new high-temperature polymorph of 5-(4-pyridyl)tetrazole was discovered and characterized using x-ray crystallog. and terahertz (THz) spectroscopy. The THz spectrum of the new polymorph was compared to the previously published form and was replicated by solid-state d. functional theory. Terahertz spectroscopy was used to determine the influence of the different packing motifs on the mol. and low energy lattice vibrations displayed at 10-100 cm-1. There is only a ∼ 2 cm-1 difference in the primary peak location, caused by a whole mol. rotation along the principal a axis, between the two polymorphic forms. The energy of formation was determined, and the previously known polymorphic form is more stable by ∼0.25 kJ/mol, compared to the newly discovered form.

Different reactions of this compound(5-(4-Pyridyl)-1H-tetrazole)Safety of 5-(4-Pyridyl)-1H-tetrazole require different conditions, so the reaction conditions are very important.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Mueller, Thomas E.; Choi, Sam Wing-Kin; Mingos, D. Michael P.; Murphy, Don; Williams, David J.; Yam, Vivian Wing-Wah published the article 《Synthesis, structural characterization and photophysical properties of ethyne-gold(I) complexes》. Keywords: crystal structure ethyne gold complex; mol structure ethyne gold complex; UV ethyne gold complex; luminescence ethyne gold complex.They researched the compound: Tri(naphthalen-1-yl)phosphine( cas:3411-48-1 ).Product Details of 3411-48-1. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:3411-48-1) here.

Closely related ethynyl-Au(I) complexes were synthesized by reaction of Au(PR3)Cl with an alk. solution of the ethyne. The mol. structures of the ethynediyl-digold complexes NpPh2PAuCCAuPNpPh2·2CHCl3 (1) (Np = naphthyl), Np2PhPAuCCAuPNp2Ph·6CHCl3 (2) and Fc2PhPAuCC-AuPFc2Ph·4EtOH (3) (Fc = ferrocenyl) and the phenylethynyl-Au complex Fc2PhPAuCC-Ph (4) were determined by single-crystal x-ray diffraction measurements. Variation of the phosphines does not have a significant influence on the bonding in the central P-Au-CC unit, the Au-P and Au-C distances being in the ranges 2.274(4)-2.289(5) and 1.983(8)-2.002(6) Å, resp. Although none of the compounds have short Au…Au contacts, compounds 1 and 2 do show novel C-H…π interactions between the proton of CHCl3 and the π-electron system of the CC bond. In 1, pairs of CHCl3 mols. are located with their protons 2.4 Å from the center of the CC bond with the C-H bond directed orthogonally towards the center of the ethyne bond. In 2, two pairs of CHCl3 mols. are located around the CC bond, with 2.5 Å between the proton and the center of the triple bond, resulting in a pseudo-octahedral arrangement around CC. In addition to the C-H…π interactions, the structures of 1 and 2 also show a range of intermol. aromatic-aromatic interactions. The 1st structural determination of naphthylphosphines resulted in estimates of their steric requirements. The UV-visible spectra of CH2Cl2 solutions of the ethynediyl compounds exhibit intense absorption bands at ∼300 nm assignable to intraligand transitions. Excitation of solid sample or fluid solution of complex 1 at λ>330 nm resulted in intense long-lived luminescence. Excitation of a solution of 2 at 350 and 380 nm led to different types of photoluminescence.

The article 《Synthesis, structural characterization and photophysical properties of ethyne-gold(I) complexes》 also mentions many details about this compound(3411-48-1)Product Details of 3411-48-1, you can pay attention to it, because details determine success or failure

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Name: 1,5-Dibromopentane. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1,5-Dibromopentane, is researched, Molecular C5H10Br2, CAS is 111-24-0, about Study of Reaction Rate between Zinc(II)-Histidine [Zn(II)-his]+ Complex and Ninhydrin: Effect of Three Dicationic Gemini (Alkanediyl-α,ω-Type) Surfactants. Author is Kumar, Dileep; Rub, Malik Abdul.

Reaction rate between Zn(II)-histidine and ninhydrin in three dicationic gemini (alkanediyl-α,ω-type) surfactants has been investigated at 343 K by spectroscopic methods. The first- and fractional-order dependencies of the reaction rate on concentration of [Zn(II)-his]+ complex and ninhydrin, resp., have been detected. Critical micellar concentrations of pure surfactants and their mixtures were determined with the help of conductometry. Effects of all three gemini (alkanediyl-α,ω-type) surfactants on the rate at different concentrations were studied.

The article 《Study of Reaction Rate between Zinc(II)-Histidine [Zn(II)-his]+ Complex and Ninhydrin: Effect of Three Dicationic Gemini (Alkanediyl-α,ω-Type) Surfactants》 also mentions many details about this compound(111-24-0)Name: 1,5-Dibromopentane, you can pay attention to it, because details determine success or failure

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Synthetic Route of C30H21P. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Tri(naphthalen-1-yl)phosphine, is researched, Molecular C30H21P, CAS is 3411-48-1, about Regioselective Palladium-Catalyzed Formate Reduction of N-Heterocyclic Allylic Acetates. Author is Cheng, Hsiu-Yi; Sun, Chong-Si; Hou, Duen-Ren.

The regioselective palladium-catalyzed formate reduction of allylic acetates in five- to eight-membered heterocycles is reported. Reduction of allylic acetates under mild conditions using allylpalladium chloride dimer, phosphines, and formic acid/triethylamine in DMF gave the exo-cyclic olefins in good regioselectivities and high yields. Synthetic application in preparing N-tosyl-3-oxo-piperidine is also reported.

The article 《Regioselective Palladium-Catalyzed Formate Reduction of N-Heterocyclic Allylic Acetates》 also mentions many details about this compound(3411-48-1)Synthetic Route of C30H21P, you can pay attention to it, because details determine success or failure

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Synthetic Route of C5H10Br2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1,5-Dibromopentane, is researched, Molecular C5H10Br2, CAS is 111-24-0, about Kinetic study of the metal-dipeptide complex with ninhydrin facilitated by gemini (m-s-m) surfactant micelles.

The three Gemini (m-s-m; m (head group) = 16 and s (spacer) = 4, 5, 6) surfactants have been synthesized and their impact on reaction of zinc(II)-glycylleucine complex ([Zn(II)-Gly-Leu]+) and ninhydrin were studied at temperature (343 K) and pH (5.0) using spectroscopic method. Influence of several factors, viz., [Zn(II)-Gly-Leu]+, [ninhydrin], temperature and pH were also carried out on title reaction in geminis. Rates of reaction are the first-order path in concentration of [Zn(II)-Gly-Leu]+ complex and fractional order path in concentration of ninhydrin. The catalysis of gemini 16-s-16 surfactant micelles was investigated below and above their critical micelle concentration (cmc) value and detailed elaboration were provided in the text. In the present case, rate constants, kψ, increased on increasing geminis ([gemini] are below their cmc, region I) and stayed nearly constant (region II). The shape of (region I and II) surfactants ([gemini] = 0 to 400 × 10-5 mol dm-3) are similar to a cetyltrimethylammonium bromide, CTAB (single hydrophilic head group and hydrophobic part). Later, a sharp increment in rate was observed with higher [gemini] (region III, (Fig. 5)). The study was catalyzed and accelerated quite enough by geminis (at concentrations below their cmc) compared to aqueous An appropriate mechanism has been proposed for accounting for the distribution of reactants between aqueous and micellar pseudo phases. Resulting kinetic data were used to determine the binding constants of micelle-substrate (KB) and micelle-ninhydrin (KNin).

The article 《Kinetic study of the metal-dipeptide complex with ninhydrin facilitated by gemini (m-s-m) surfactant micelles》 also mentions many details about this compound(111-24-0)Synthetic Route of C5H10Br2, you can pay attention to it or contacet with the author([email protected]) to get more information.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Wen, Xiaojin; Li, Xinyao; Luo, Xiao; Wang, Weijin; Song, Song; Jiao, Ning published an article about the compound: 1,5-Dibromopentane( cas:111-24-0,SMILESS:BrCCCCCBr ).Product Details of 111-24-0. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:111-24-0) through the article.

The intramol. Csp3-H and/or C-C bond amination was very important in modern organic synthesis due to its efficiency in the construction of diversified N-heterocycles. A novel intramol. cyclization of alkyl azides for the synthesis of cyclic imines I [Ar = Ph, 4-MeC6H4, 4-OMeC6H4, etc.; R = H, 2-Me, 2-Et, etc.] and tertiary amines II [n = 1, 2] through selective Csp3-H and/or C-C bond cleavage was reported. Two C-N single bonds or a C=N double bond were efficiently constructed in these transformations. The carbocation mechanism differed from the reported metal nitrene intermediates and therefore enabled metal-free and new transformation.

The article 《Intramolecular Csp3-H/C-C bond amination of alkyl azides for the selective synthesis of cyclic imines and tertiary amines》 also mentions many details about this compound(111-24-0)Product Details of 111-24-0, you can pay attention to it or contacet with the author([email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]) to get more information.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis