Category: chiral-nitrogen-ligands

Electric Literature of C26H24P2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1,2-Bis(diphenylphosphino)ethane, is researched, Molecular C26H24P2, CAS is 1663-45-2, about Fully Solvated, Monomeric ReII Complexes: Insights into the Chemistry of [Re(NCCH3)6]2+. Author is Bolliger, Robin; Meola, Giuseppe; Braband, Henrik; Blacque, Olivier; Siebenmann, Lukas; Nadeem, Qaisar; Alberto, Roger.

The oxidation of [Re(η6-C10H8)2]+ with AgI in acetonitrile yields [Re(NCCH3)6]2+. This fully solvated ReII compound was characterized by spectroscopic methods and x-ray structure analyses. Authors show that [Re(NCCH3)6]2+ acts as a precursor complex for a variety of substitution reactions. Treatment with monodentate triphenylphosphine (PPh3) and bidentate 1,2-bis(diphenylphosphino)ethane (dppe) yields the complexes [trans-Re(PPh3)2(NCCH3)4]2+ and [trans-Re(dppe)2(NCCH3)2]+, resp. [trans-Re(dppe)2(NCCH3)2]+ is oxidized under mild conditions by AgI to its ReII analog [trans-Re(dppe)2(NCCH3)2]2+. Reactions of [Re(NCCH3)6]2+ with a halide mixture consisting of NaX and AgX (X = Cl, I) result in the formation of the corresponding ReIII complexes [trans-ReX2(NCCH3)4]+. [Trans-ReBr2(NCCH3)4]+ can be obtained directly from [Re(η6-C10H8)2]+ by oxidation with FeBr3 in acetonitrile. The title compound is thus a convenient starting material for ReII and ReIII complexes by simple solvent exchange, which are otherwise difficult to access.

After consulting a lot of data, we found that this compound(1663-45-2)Electric Literature of C26H24P2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Recommanded Product: 2-Aminoquinazolin-4(3H)-one. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Exploring the Limits of DNA Size: Naphtho-Homologated DNA Bases and Pairs. Author is Lee, Alex H. F.; Kool, Eric T..

A new design for DNA bases and base pairs is described in which the pyrimidine bases are widened by naphtho-homologation. Two naphtho-homologated deoxyribosides, dyyT (1) and dyyC (2), were synthesized and could be incorporated into oligonucleotides as suitably protected phosphoramidite derivatives The deoxyribosides were found to be fluorescent, with emission maxima at 446 and 433 nm, resp. Studies with single substitutions of 1 and 2 in the natural DNA context revealed exceptionally strong base stacking propensity for both. Sequences containing multiple substitutions of 1 and 2 paired opposite adenine and guanine were subsequently mixed and studied by several anal. methods. Data from UV mixing experiments, FRET measurements, fluorescence quenching experiments, and hybridizations on beads suggest that complementary “”double-wide DNA”” (yyDNA) strands may self-assemble into helical complexes with 1:1 stoichiometry. Data from thermal denaturation plots and CD spectra were less conclusive. Control experiments in one sequence context gave evidence that yyDNA helixes, if formed, are preferentially antiparallel and are sequence. Hypothesized base pairing schemes are analogous to Watson-Crick pairing, but with glycosidic C1′-C1′ distances widened by over 45%, to ca. 15.2 Å. The possible self-assembly of the double-wide DNA helix establishes a new limit for the size of information-encoding, DNA-like mols., and the fluorescence of yyDNA bases suggests uses as reporters in monomeric and oligomeric forms.

After consulting a lot of data, we found that this compound(20198-19-0)Recommanded Product: 2-Aminoquinazolin-4(3H)-one can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Application of 14389-12-9. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 5-(4-Pyridyl)-1H-tetrazole, is researched, Molecular C6H5N5, CAS is 14389-12-9, about Synthesis, structures and characterization of two mononuclear Ru(III)-edta complexes. Author is Kuang, Wei-wei; Yang, Pei-pei.

Two ruthenium (III) complexes containing ethylenediaminetetraacetate (EDTA), [Ru(Hedta)(4-ptz)].4H2O (1) and [Ru(Hedta)(2,5-Pydc)]·3H2O (2), were synthesized by the K[Ru(Hedta)Cl]·1.5H2O reacting with 5-(4-pyridyl)tetrazole (4-ptz) or 2,5-pyridinedicarboxylic acid (2,5-Pydc) in water solution Complex 1 crystallized in monoclinic system, space group C2/c with a 2.34806(15), b 1.30123(8), c 1.49308(9) nm, β 101.0750(10)°. Complex 2 crystallizes in monoclinic system, space group I2/a with a 3.2494(7), b 0.96623(19), c 1.4341(3) nm, β 93.88(3)°. The products were characterized by IR and UV-visible. Their DNA-binding activities were studied using electronic absorption spectroscopic methods and fluorescence quenching; these two ruthenium complexes may bind to CT-DNA through intercalation modes.

After consulting a lot of data, we found that this compound(14389-12-9)Application of 14389-12-9 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Recommanded Product: 5-(4-Pyridyl)-1H-tetrazole. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-(4-Pyridyl)-1H-tetrazole, is researched, Molecular C6H5N5, CAS is 14389-12-9, about Cu(II) immobilized on aminated epichlorohydrin activated silica (CAES): as a new, green and efficient nanocatalyst for preparation of 5-substituted-1H-tetrazoles. Author is Razavi, Nasrin; Akhlaghinia, Batool.

Cu(II) immobilized on aminated epichlorohydrin activated silica (CAES) is a novel and efficient heterogeneous nanocatalyst in the [3 + 2] cycloaddition reactions of various organic nitriles with sodium azide. The protocol can provide a series of 5-substituted-1H-tetrazoles under mild conditions in DMSO. Efficient transformation, mild reaction conditions, easy product isolation and the potential reusability of the catalyst are attractive features. The catalyst (CAES) was characterized by FT-IR, TGA, TEM, BET, SEM-EDS, CHN and ICP techniques.

After consulting a lot of data, we found that this compound(14389-12-9)Recommanded Product: 5-(4-Pyridyl)-1H-tetrazole can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 111-24-0, is researched, SMILESS is BrCCCCCBr, Molecular C5H10Br2Journal, Article, Chemistry – A European Journal called Realization of an Asymmetric Non-Aqueous Redox Flow Battery through Molecular Design to Minimize Active Species Crossover and Decomposition, Author is Shrestha, Anuska; Hendriks, Koen H.; Sigman, Mathew S.; Minteer, Shelley D.; Sanford, Melanie S., the main research direction is asym redox flow battery mol design; active specie crossover decomposition minimization; anolyte decomposition; asymmetric; crossover; non-aqueous; redox flow batteries.Reference of 1,5-Dibromopentane.

This communication presents a mechanism-based approach to identify organic electrolytes for non-aqueous redox flow batteries (RFBs). Sym. flow cell cycling of a pyridinium anolyte and a cyclopropenium catholyte resulted in extensive capacity fade due to competing decomposition of the pyridinium species. Characterization of this decomposition pathway enabled the rational design of next-generation anolyte/catholyte pairs with dramatically enhanced cycling performance. Three factors were identified as critical for slowing capacity fade, separating the anolyte-catholyte in an asym. flow cell using an anion exchange membrane (AEM), moving from monomeric to oligomeric electrolytes to limit crossover through the AEM, and removing the basic carbonyl moiety from the anolyte to slow the protonation-induced decomposition pathway. Ultimately, these modifications led to a novel anolyte-catholyte pair that can be cycled in an AEM-separated asym. RFB for 96 h with > 95 % capacity retention at an open circuit voltage of 1.57 V.

After consulting a lot of data, we found that this compound(111-24-0)Reference of 1,5-Dibromopentane can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Quantitative structure-activity study of some enzyme-inhibitory quinazolines.Name: 2-Aminoquinazolin-4(3H)-one.

Relations are formulated to explain the variation in dihydrofolate reductase [9002-03-3] inhibitory potency for a series of 25 substituted quinazolines I(R = H, OH, NH2, AcNH; R1 = H, NH2, OH, SH; R2 = H, Cl, Me; R3 = H, Me, NH2, Cl, CN, CHO, Br, CH2NH2) with an antineoplastic potential. Highly significant correlations are obtained using CNDO/2-3R calculated indexes and(or) the empirically estimated mol. polarizability as independent variables. The MO calculated indexes employed are the at. polarizability, as defined herein, and bond energy. The mol. polarizability is represented by a simple sum of environment-independent partial at. polarizabilities. The partial polarizabilities, reported here for H, C, N, O, F, S, Cl, and Br, are obtained from a multiple regression forced through the origin.

After consulting a lot of data, we found that this compound(20198-19-0)Name: 2-Aminoquinazolin-4(3H)-one can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Electric Literature of C30H21P. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Tri(naphthalen-1-yl)phosphine, is researched, Molecular C30H21P, CAS is 3411-48-1, about Mechanistic Investigations of Reactions of the Frustrated Lewis Pairs (Triarylphosphines/B(C6F5)3) with Michael Acceptors. Author is Dupre, Jonathan; Gaumont, Annie-Claude; Lakhdar, Sami.

Frustrated Lewis pair (FLP)-catalyzed reduction of Michael acceptors is a challenging reaction that proceeds with specific FLP structures. Kinetics and equilibrium of the reactions of two phosphines (Ar3P), namely tri(1-naphthyl)phosphine and tri(o-tolyl)phosphine, are reported with reference electrophiles. The reason for the failure of the FLPs (Ar3P/B(C6F5)3) to reduce activated alkenes under H2 pressure is shown to be a hydrophosphination process that inhibits the reduction reaction. Kinetic and thermodn. factors controlling both pathways are discussed in light of Mayr’s free linear energy relationships.

After consulting a lot of data, we found that this compound(3411-48-1)Electric Literature of C30H21P can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Carbonylation of organic halo derivatives into acids in the presence of palladium complexes, published in 1982-06-30, which mentions a compound: 3411-48-1, Name is Tri(naphthalen-1-yl)phosphine, Molecular C30H21P, SDS of cas: 3411-48-1.

The reactions of organic halides with CO to give carboxylic acids were catalyzed by the reaction products of (PhCN)2PdCl2 (I) with different ligands, e.g., phosphines, stilbines, sulfides, and quinone. Tertiary phosphines, especially Ph3P, were the most effective ligands. The activity of the halides increased in the following orders: alkyl < Ph < benzyl and Cl < Br < I. With Ph3P and I the optimal P/Pd ratio was 4-6. After consulting a lot of data, we found that this compound(3411-48-1)SDS of cas: 3411-48-1 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Zeslawska, Ewa; Kucwaj-Brysz, Katarzyna; Kincses, Annamaria; Spengler, Gabriella; Szymanska, Ewa; Czopek, Anna; Marc, Malgorzata Anna; Kaczor, Aneta; Nitek, Wojciech; Dominguez-Alvarez, Enrique; Latacz, Gniewomir; Kiec-Kononowicz, Katarzyna; Handzlik, Jadwiga researched the compound: 1,5-Dibromopentane( cas:111-24-0 ).Quality Control of 1,5-Dibromopentane.They published the article 《An insight into the structure of 5-spiro aromatic derivatives of imidazolidine-2,4-dione, a new group of very potent inhibitors of tumor multidrug resistance in T-lymphoma cells》 about this compound( cas:111-24-0 ) in Bioorganic Chemistry. Keywords: arylpiperazinyl spiroimidazolidinedione preparation docking antitumor crystal multidrug resistance lymphoma; Crystal structure; Fluorene; Hydantoin; Multidrug resistance; P-glycoprotein (ABCB1); T-lymphoma. We’ll tell you more about this compound (cas:111-24-0).

A series of arylpiperazine derivatives of the 5-spiroimidazolidine-2,4-diones I/I·HCl (n = 3, 4, 5; R = Ph, Bn, 4-nitrophenyl, diphenylmethyl, 3-chlorophenyl), II (m = 1, 2; R1 = H, CF3) and III has been explored, including variations in the number of aromatic rings at position 5 and the length of the linker, as well as the kind and position of the linked arylpiperazine terminal fragment. Synthesis I/I·HCl and X-ray crystallog. studies for representative compounds I (n = 4; R = Bn), I·HCl (n = 3, R = Bn; n = 5, R = Ph) and II (m = 2; R1 = H (III)) have been performed. The ability to inhibit the tumor multidrug resistance (MDR) efflux pump P-glycoprotein (P-gp, ABCB1) overexpressed in mouse T-lymphoma cells was investigated. The cytotoxic and antiproliferative actions of the compounds on both the reference and the ABCB1-overproducing cells were also examined The pharmacophore-based mol. modeling studies have been performed. ADMET properties in vitro of selected most active derivatives I (n = 4; R = 4-nitrophenyl) and I·HCl (n = 3, R = Ph; n = 4, R = diphenylmethyl (IV)) have been determined All compounds, excluding III, inhibited the cancer P-gp efflux pump with higher potency than that of reference verapamil. The spirofluorene derivatives with amine alkyl substituents at position 1, and the Me group at position 3 (I/I·HCl), occurred the most potent P-gp inhibitors in the MDR T-lymphoma cell line. In particular, compounds I·HCl (n = 3; R = 4-nitrophenyl) and IV were 100-fold more potent than verapamil. Crystallog.-supported pharmacophore-based SAR anal. has postulated specific structural properties that could explain this excellent cancer MDR-inhibitory action.

After consulting a lot of data, we found that this compound(111-24-0)Quality Control of 1,5-Dibromopentane can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Quality Control of Tri(naphthalen-1-yl)phosphine. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Tri(naphthalen-1-yl)phosphine, is researched, Molecular C30H21P, CAS is 3411-48-1, about C-H Bond Activation by Radical Ion Pairs Derived from R3P/Al(C6F5)3 Frustrated Lewis Pairs and N2O. Author is Menard, Gabriel; Hatnean, Jillian A.; Cowley, Hugh J.; Lough, Alan J.; Rawson, Jeremy M.; Stephan, Douglas W..

Al(C6F5)3/R3P [R = tert-Bu (tBu), mesityl (Mes), naphthyl (Nap)] frustrated Lewis pairs react with N2O to form species having the formula R3P(N2O)Al(C6F5)3, which react with addnl. alane to generate proposed frustrated radical ion pairs formulated as [R3P·][(μ-O·)(Al(C6F5)3)2] that can activate C-H bonds. For R = tBu, C-H activation of a tBu group affords [tBu2PMe(C(CH2)Me)][(μ-OH)(Al(C6F5)3)2]. In the case of R = Mes, the radical cation salt [Mes3P·][(μ-HO)(Al(C6F5)3)2] is isolated, while for R = Nap, the activation of toluene and bromobenzene gives [(Nap)3PCH2Ph][(μ-OH)(Al(C6F5)3)2] and [(Nap)3PC6H4Br][(μ-HO)(Al(C6F5)3)2], resp.

After consulting a lot of data, we found that this compound(3411-48-1)Quality Control of Tri(naphthalen-1-yl)phosphine can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis