The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《New route to diazine mono-N-oxides》. Authors are Taylor, E. C.; Jefford, C. W..The article about the compound:2-Aminoquinazolin-4(3H)-onecas:20198-19-0,SMILESS:O=C1NC(N)=NC2=C1C=CC=C2).Recommanded Product: 2-Aminoquinazolin-4(3H)-one. Through the article, more information about this compound (cas:20198-19-0) is conveyed.
Treatment of o-O2NC6H4NCO with KCN in aqueous alkali gave o-O2NC6H4NHCOCN, m. 98°, hydrogenation of which in EtOH over PtO2 yielded I, m. 323°. Reduction of I in EtOH-MeNH2 with H and Raney Ni gave 2-amino-3(4H)-quinoxalone, m. >360°. Treatment of H2NCN with o-O2NC6H4COCl in the presence of alkali yielded o-O2NC6H4CONHCN, m. 125°, which was reduced over PtO2 to II, m. 381° (decomposition). Reduction of II with H over Raney Ni gave 2-amino-4(3H)-quinazolone, m. 313° (decomposition).
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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis