Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Quinazolines. VIII. Reaction of 2-aminoquinazol-4-one with unsaturated acids.Category: chiral-nitrogen-ligands.
Pyrimidoquinazolinediones I (R = H, Me, Ph, R1 = R2 = H; R = R1 = H, R2 = Me; R = R1 = Me, R2 = H) were obtained in 61-90% yields by cyclocondensation of RR1C:CR2CO2H with 2-amino-4(3H)-quinazolinone 2 h at 160-5°.
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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis