Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Quantitative structure-activity study of some enzyme-inhibitory quinazolines.Name: 2-Aminoquinazolin-4(3H)-one.
Relations are formulated to explain the variation in dihydrofolate reductase [9002-03-3] inhibitory potency for a series of 25 substituted quinazolines I(R = H, OH, NH2, AcNH; R1 = H, NH2, OH, SH; R2 = H, Cl, Me; R3 = H, Me, NH2, Cl, CN, CHO, Br, CH2NH2) with an antineoplastic potential. Highly significant correlations are obtained using CNDO/2-3R calculated indexes and(or) the empirically estimated mol. polarizability as independent variables. The MO calculated indexes employed are the at. polarizability, as defined herein, and bond energy. The mol. polarizability is represented by a simple sum of environment-independent partial at. polarizabilities. The partial polarizabilities, reported here for H, C, N, O, F, S, Cl, and Br, are obtained from a multiple regression forced through the origin.
After consulting a lot of data, we found that this compound(20198-19-0)Name: 2-Aminoquinazolin-4(3H)-one can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis