Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 4767-03-7, Name is 3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoic acid, molecular formula is C5H10O4, belongs to chiral-nitrogen-ligands compound, is a common compound. In a patnet, author is Wu, Lin-Yang, once mentioned the new application about 4767-03-7, Application In Synthesis of 3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoic acid.
Enantioselective Iron/Bisquinolyldiamine Ligand-Catalyzed Oxidative Coupling Reaction of 2-Naphthols
An iron-catalyzed asymmetric oxidative homo-coupling of 2-naphthols for the synthesis of 1,10-Bi-2-naphthol (BINOL) derivatives is reported. The coupling reaction provides enantioenriched BINOLs in good yields (up to 99%) and moderate enantioselectivities (up to 81:19 er) using an iron-complex generated in situ from Fe(ClO4)(2) and a bisquinolyldiamine ligand [(1R,2R)-N1,N2di(quinolin-8-yl)cyclohexane-1,2-diamine, L1]. A number of ligands (L2-L8) and the analogs of L1, with various substituents and chiral backbones, were synthesized and examined in the oxidative coupling reactions.
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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
,Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis