Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 20198-19-0, is researched, SMILESS is O=C1NC(N)=NC2=C1C=CC=C2, Molecular C8H7N3OJournal, Journal fuer Praktische Chemie (Leipzig) called The nitrile-carboxamide rearrangement and the formation of heterocycles from 2-cyanocyclohexenylurea, Author is Bischoff, Christian; Schroeder, Edith, the main research direction is nitrile carboxamide rearrangement; cyanocyclohexenylurea cyclization transamination amine; cyclohexenylurea cyano reaction amine; urea cyanocyclohexenyl reaction amine.Formula: C8H7N3O.
2-H2NC6H4CONH2 reacted with BrCN to give 85% 2-NCC6H4NHCONH2 via a nitrile-carboxamide rearrangement. Cyclohexenylurea I (R = R1 = H) reacted with amines to give 35-100% cyclization products II (R2 = 4-ClC6H4, 2,4,5-Cl3C6H2, Ph, PhCH2, 1-naphthyl, 4-O2NC6H4, H), with amines to give 29-86% transamination products I [NRR1 = NHCHMe2, NH(CH2)5CO2H, morpholino, piperidino], and with α-amino acids to give 32-49% cyclization products III (R3 = H, Pr). 2-Oxocyclohexanecarboxamide reacted with 2-aminobenzimidazole to give 100% benzimidazoquinazolinone IV.
I hope my short article helps more people learn about this compound(2-Aminoquinazolin-4(3H)-one)Formula: C8H7N3O. Apart from the compound(20198-19-0), you can read my other articles to know other related compounds.
Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis