The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1,5-Dibromopentane(SMILESS: BrCCCCCBr,cas:111-24-0) is researched.Reference of 2-Aminoquinazolin-4(3H)-one. The article 《Design, synthesis and biological evaluation of new carbazole-coumarin hybrids as dual binding site inhibitors of acetylcholinesterase》 in relation to this compound, is published in Journal of Molecular Structure. Let’s take a look at the latest research on this compound (cas:111-24-0).
Twelve carbazole-coumarin hybrids I (n = 2, 3, 4, 5; R = H, Me) and II were synthesized and biol. evaluated as dual binding site acetylcholinesterase inhibitors. The compound II (n = 3) had the crystal system of triclinic and the space group of P-1. The cholinesterase inhibitory activity of synthesized compounds I and II was measured using colorimetric Ellman’s method. Compound I [n = 5; R = Me] (III) exhibited good acetylcholinesterase (AChE) inhibitory activity (IC50 value of 6.72μM) and a high selectivity over butyrylcholinesterase (BuChE). Compound II (n = 4) showed the best BuChE inhibitory activity with the IC50 of 0.50μM. The SAR studies revealed that the linker length played a crucial role in determining AChE inhibitory activity and the structure of the coumarin moieties affected the BuChE-inhibition activities of the hybrids. Mol. docking study of compound III indicated that it interacts with the crucial amino acids present at the catalytic active site and peripheral anionic site of AChE. Compound III would be a promising drug candidate to treat AD as a selective and dual binding site inhibitor of AChE.
In some applications, this compound(111-24-0)Formula: C5H10Br2 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis