Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Inflammopharmacology called Immunomodulatory properties of characellide A on human peripheral blood mononuclear cells, Author is Marcella, Simone; Afoullouss, Sam; Thomas, Olivier P.; Allcock, A. Louise; Murphy, Paul V.; Loffredo, Stefania, which mentions a compound: 1663-45-2, SMILESS is P(CCP(C1=CC=CC=C1)C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4, Molecular C26H24P2, Computed Properties of C26H24P2.
Marine sponges and their associated microbiota are multicellular animals known to produce metabolites with interesting pharmacol. properties playing a pivotal role against a plethora of pathol. disorders such as infammation, cancer and infections. Characellide A and B belong to a novel class of glycolipopeptides isolated from the deep sea marine sponge Characella pachastrelloides. In this study, we have evaluated the efects of characellide A and B on cytokine and chemokine release from human peripheral blood mononuclear cells (PBMC). Characellide A induces a concentration- and time-dependent CXCL8, IL-6 and TNF-α release from PBMC. This production is mediated by the induction of gene transcription. Moreover, cytokine/chemokine release induced by characellide A from PBMC is CD1d-dependent because a CD1d antagonist, 1,2-bis(diphenylphosphino)ethane [DPPE]-polyethylene glycolmonomethylether [PEG], specifcally inhibits characellide A-induced activation of PBMC. In conclusion, characellide A is a novel modulator of adaptative/innate immune responses. Further studies are needed to understand its potential pharmacol. application.
Although many compounds look similar to this compound(1663-45-2)Computed Properties of C26H24P2, numerous studies have shown that this compound(SMILES:P(CCP(C1=CC=CC=C1)C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis