In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis, characterization, crystal structure and evaluation of four carbazole-coumarin hybrids as multifunctional agents for the treatment of Alzheimer’s disease, published in 2020-06-05, which mentions a compound: 111-24-0, Name is 1,5-Dibromopentane, Molecular C5H10Br2, Category: chiral-nitrogen-ligands.
Coupling of two distinct pharmacophores carbazole and coumarin endowed with different biol. properties afforded four hybrid compounds I [n = 3,5] and II. The structures of the carbazole-coumarin hybrids I and II were characterized by FT-IR, NMR, HRMS and single-crystal X-ray diffraction studies. All of these compounds I and II exhibited significant acetylcholinesterase inhibitory activities. Among them, compound II [n = 5] exhibited the best inhibition activity with IC50 of 3.75μM for acetylcholinesterase from elec. eel and 70.51μM for human recombinant acetylcholinesterase. Moreover, the compound I [n = 3] was showed the best antioxidant activity. The docking studies demonstrated that compound II [n = 5] could interacted with both the catalytic active site and the peripheral anionic site of acetylcholinesterase. These attributed imply carbazole-coumarin hybrids as multifunctional agents for the Alzheimer’s disease treatment.
In some applications, this compound(111-24-0)Category: chiral-nitrogen-ligands is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis