Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Shan, Meng, once mentioned the application of 96-47-9, Name is 2-Methyltetrahydrofuran, molecular formula is C5H10O, molecular weight is 86.1323, MDL number is MFCD00005367, category is chiral-nitrogen-ligands. Now introduce a scientific discovery about this category, Safety of 2-Methyltetrahydrofuran.
Enantioselective rearrangement of indolyl carbonates catalyzed by chiral DMAP-N-oxides
Bifunctional chiral DMAP-N-oxides have been reported for the highly enantioselective rearrangement of indolyl carbonates. Using 2.5 mol% of chiral DMAP-N-oxide, diverse oxindoles containing an all-carbon quaternary stereocenter were obtained in excellent yields (up to 98% yield) with high enantioselectivities (up to 96% ee). Compared to the widespread use of chiral DMAP and isothiourea catalysts, in which the nitrogen atom serves as a nucleophilic site, we found that chiral DMAP-N-oxides, which utilize the oxygen atom as a nucleophilic site, were also efficient organocatalysts in this rearrangement.
Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 96-47-9, Safety of 2-Methyltetrahydrofuran.
Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
,Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis