Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. category: chiral-nitrogen-ligands. Introducing a new discovery about 126456-43-7, Name is (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol
Enantioselective acylation of 1,2- and 1,3-diols catalyzed by aminophosphinite derivatives of (1 S,2 R)-1-amino-2-indanol
A phosphinite derivative that can be easily prepared in two steps from commercially available aminoindanol was found to be an effective catalyst for enantioselective acylation of diols. For the asymmetric desymmetrization of meso-1,2-diols, the corresponding monoester was obtained in up to 95% ee from the reaction in the presence of 5 mol % catalyst.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.category: chiral-nitrogen-ligands, you can also check out more blogs about126456-43-7
Reference£º
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis