Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 136030-00-7, Name is (1R,2S)-1-Amino-2,3-dihydro-1H-inden-2-ol, molecular formula is C9H11NO, belongs to chiral-nitrogen-ligands compound, is a common compound. In a patnet, author is Shang, Ming, once mentioned the new application about 136030-00-7, Product Details of 136030-00-7.
C-H Functionalization of Amines via Alkene-Derived Nucleophiles through Cooperative Action of Chiral and Achiral Lewis Acid Catalysts: Applications in Enantioselective Synthesis
Catalytic transformations of alpha-amino C-H bonds to afford valuable enantiomerically enriched alpha-substituted amines, entities that are prevalent in pharmaceuticals and bioactive natural products, have been developed. Typically, such processes are carried out under oxidative conditions and require precious metal-based catalysts. Here, we disclose a strategy for an enantioselective union of N-alkylamines and alpha,beta-unsaturated compounds, performed under redox-neutral conditions, and promoted through concerted action of seemingly competitive Lewis acids, B(C6F5)(3), and a chiral Mg-PyBOX complex. Thus, a wide variety of beta-amino carbonyl compounds may be synthesized, with complete atom economy, through stereoselective reaction of an in situ-generated enantiomerically enriched Mg-enolate and an appropriate electrophile.
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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
,Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis