Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction by binding to a specific portion of an enzyme and thus slowing or preventing a reaction from occurring. Electric Literature of 126456-43-7,126456-43-7, name is (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol. In an article，Which mentioned a new discovery about 126456-43-7
The enantiomeric excess is a key parameter for chemical and pharmaceutical industries for its ability to determine the activity and therapeutic action of chiral compounds. The determination of the enantiomeric excess using nuclear magnetic resonance is generally based on the formation of diastereomeric complexes. Herein we report novel chiral oxo-bridged calix[2]arene[2]triazine derivatives, which were synthesized from (1S,2R)-(-)-1-amino-2-indanol or (1S,2R)-(+)-2-amino-1,2-diphenylethanol. The structures of these compounds were established by various spectroscopic methods. Their enantiomeric recognition abilities towards the enantiomers of alpha-racemic carboxylic acids were examined by using 1H NMR spectroscopy. The DeltaDeltadelta values of alpha-H signals were appropriate to give a good baseline resolution for most of the tested analytes, which ranged from 0.005 to 0.053 ppm. The alpha-hydroxy acids, especially those containing aromatic group such as mandelic acid, alpha-methoxyphenylacetic acid, showed a bigger DeltaDeltadelta value in comparison to the other carboxylic acids.
Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. In my other articles, you can also check out more blogs about 126456-43-7
Reference：
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis