In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 108-47-4, name is 2,4-Dimethylpyridine, introducing its new discovery. name: 2,4-Dimethylpyridine
Structure-activity study of pyridine derivatives inhibiting thromboxane synthetase
The relationship between the structure of the side chain of pyridine derivatives and the inhibitory potency towards thromboxane synthetase was quantitatively analyzed by the adaptive least-squares (ALS) method. The main descriptors concerning the molecular structure used in the analysis were estimated on the basis of the minimum energy conformation obtained from MINDO/3 molecular orbital calculation. All of 27 pyridine derivatives were recognized correctly by the best discriminant function. Validity of the discriminant function was tested by the leave-one-out technique. The activity ratings of 23 compounds could be predicted correctly with the descriptors used in the best function. Application of this relationship to the design of inhibitors and the mode of enzyme-inhibitor interaction were discussed.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 108-47-4, and how the biochemistry of the body works.name: 2,4-Dimethylpyridine
Reference£º
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis